{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:02:09Z","timestamp":1784606529364,"version":"3.55.0"},"reference-count":33,"publisher":"World Scientific Pub Co Pte Ltd","issue":"05","funder":[{"name":"the Shenzhen Science and Technology Program","award":["JCYJ20230807094503006"],"award-info":[{"award-number":["JCYJ20230807094503006"]}]},{"name":"the Shenzhen Science and Technology Program","award":["JCYJ20230807094503007"],"award-info":[{"award-number":["JCYJ20230807094503007"]}]},{"name":"the Shenzhen Traditional Chinese Medicine Hospital \u201c3030 Program\u201d Chinese Medicine Clinical Research Project","award":["G3030202128"],"award-info":[{"award-number":["G3030202128"]}]},{"name":"the Sanming Project of Medicine in Shenzhen","award":["SZZYSM 202411012"],"award-info":[{"award-number":["SZZYSM 202411012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Heart failure (HF) is a high-mortality condition driven by cardiomyocyte death, and ferroptosis is a critical contributor to myocardial injury in this regard. Tanshinone IIA (Tan-IIA), a bioactive component from Salvia miltiorrhiza, has been shown to protect the heart, but its role in HF-related ferroptosis remains unclear. This study investigated whether Tan-IIA ameliorates HF by inhibiting ferroptosis and its underlying mechanism. We evaluated cardiac function, fibrosis, ferroptosis markers (such as ROS, Fe[Formula: see text], GSH, xCT, and GPX4), and Sirt1\/p53 signaling using both a mouse model of HF induced by ligation of the left anterior descending (LAD) coronary artery and oxygen\u2013glucose deprivation (OGD)-treated H9c2 cells. Direct binding of Tan-IIA to Sirt1 was verified by molecular docking, CETSA, and DARTS. Tan-IIA improved cardiac function, reduced fibrosis and inflammation, decreased ROS\/Fe[Formula: see text], increased GSH, and upregulated xCT\/GPX4 in vivo and in vitro. However, erastin reversed these effects. Tan-IIA upregulated Sirt1 and downregulated p53, while Sirt1 inhibition by EX527 abolished its cardioprotective and antiferroptotic actions. Tan-IIA ameliorates HF by inhibiting myocardial ferroptosis through the Sirt1\/p53\/GPX4 pathway thus in turn supports its potential clinical use in the treatment of HF.<\/jats:p>","DOI":"10.1142\/s0192415x26500564","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T09:49:30Z","timestamp":1783504170000},"page":"1531-1550","source":"Crossref","is-referenced-by-count":0,"title":["Tanshinone IIA Ameliorates Heart Failure by Inhibiting Ferroptosis via the Sirt1\/p53\/GPX4 Signaling Pathway"],"prefix":"10.1142","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8975-472X","authenticated-orcid":false,"given":"Guo-Fu","family":"Zhong","sequence":"first","affiliation":[{"name":"The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen 518000, China"},{"name":"Department of Intensive Care, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6515-779X","authenticated-orcid":false,"given":"Zhi-Wen","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen 518000, China"},{"name":"Department of Intensive Care, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4546-5262","authenticated-orcid":false,"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen 518000, China"},{"name":"Department of Intensive Care, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3928-9408","authenticated-orcid":false,"given":"Bo","family":"Lin","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen 518000, China"},{"name":"Department of Intensive Care, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9055-4745","authenticated-orcid":false,"given":"Qing-Hua","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen 518000, China"},{"name":"Department of Intensive Care, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9775-7805","authenticated-orcid":false,"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen 518000, China"},{"name":"Department of Intensive Care, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8428-1058","authenticated-orcid":false,"given":"Mujuan","family":"Xu","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen 518000, China"},{"name":"Department of Intensive Care, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5569-8985","authenticated-orcid":false,"given":"Yuxiang","family":"Liu","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen 518000, China"},{"name":"Department of Intensive Care, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5238-085X","authenticated-orcid":false,"given":"Maosheng","family":"Wang","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen 518000, China"},{"name":"Department of Intensive Care, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8661-455X","authenticated-orcid":false,"given":"Yue","family":"Han","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen 518000, China"},{"name":"Department of Intensive Care, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"S0192415X26500564BIB002","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.165"},{"key":"S0192415X26500564BIB003","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107281"},{"key":"S0192415X26500564BIB004","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1503628"},{"key":"S0192415X26500564BIB005","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00022.2018"},{"key":"S0192415X26500564BIB006","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk1835"},{"key":"S0192415X26500564BIB007","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199702203360801"},{"key":"S0192415X26500564BIB008","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"S0192415X26500564BIB009","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109024"},{"key":"S0192415X26500564BIB010","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.09.041"},{"key":"S0192415X26500564BIB011","first-page":"e1573403 X37098","volume":"22","author":"Gupta P.","year":"2025","journal-title":"Curr. Cardiol. Rev."},{"key":"S0192415X26500564BIB012","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.114938"},{"key":"S0192415X26500564BIB013","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.01.002"},{"key":"S0192415X26500564BIB014","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-025-01036-w"},{"key":"S0192415X26500564BIB015","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00993-3"},{"key":"S0192415X26500564BIB017","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23388"},{"key":"S0192415X26500564BIB018","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.04.006"},{"key":"S0192415X26500564BIB019","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2016.138"},{"key":"S0192415X26500564BIB020","doi-asserted-by":"publisher","DOI":"10.3390\/cancers7010030"},{"key":"S0192415X26500564BIB021","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00753"},{"key":"S0192415X26500564BIB022","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26135995"},{"key":"S0192415X26500564BIB023","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.04.029"},{"key":"S0192415X26500564BIB024","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000109701.77059.E9"},{"key":"S0192415X26500564BIB025","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.021"},{"key":"S0192415X26500564BIB026","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.7.383"},{"key":"S0192415X26500564BIB027","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn096"},{"key":"S0192415X26500564BIB028","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001123"},{"key":"S0192415X26500564BIB029","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80369"},{"key":"S0192415X26500564BIB030","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2025.02.003"},{"key":"S0192415X26500564BIB031","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2024.156048"},{"key":"S0192415X26500564BIB032","doi-asserted-by":"publisher","DOI":"10.1172\/JCI161453"},{"key":"S0192415X26500564BIB033","doi-asserted-by":"publisher","DOI":"10.7150\/thno.98172"},{"key":"S0192415X26500564BIB034","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2025.102770"},{"key":"S0192415X26500564BIB035","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.25"}],"container-title":["The American Journal of Chinese Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0192415X26500564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:09:33Z","timestamp":1784603373000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/10.1142\/S0192415X26500564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":33,"journal-issue":{"issue":"05","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1142\/S0192415X26500564"],"URL":"https:\/\/doi.org\/10.1142\/s0192415x26500564","relation":{},"ISSN":["0192-415X","1793-6853"],"issn-type":[{"value":"0192-415X","type":"print"},{"value":"1793-6853","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}