{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T13:20:42Z","timestamp":1648646442576},"reference-count":0,"publisher":"World Scientific Pub Co Pte Lt","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:p> The effects of the Chinese herb Chou-Mou-Li, Clerodenron fragrans (Ventenaceae) on metabolic, respiratory and vasomotor activities as well as body temperatures were assessed in conscious rats at three different ambient temperatures (T<jats:sub>a<\/jats:sub>) of 8, 22 and 30\u00b0C. Intraperitoneal administration of Chou-Mou-Li produced dose-dependent hypothermia in rats at both 8 and 22\u00b0C T<jats:sub>a<\/jats:sub>. At 8\u00b0C T<jats:sub>a<\/jats:sub> the hypothermia in response to Chou-Mou-Li was due to decreased metabolism, while at 22\u00b0C T<jats:sub>a<\/jats:sub> the hypothermia was due to both decreased metabolism and cutaneous vasodilatation. There was no change in respiratory evaporative heat loss. Furthermore, the hypothermia induced by Chou-Mou-Li was greatly antagonized by pretreatment of animals with p-chlorophenylalanine (a selective depletor of brain serotonin), but not by either atropine sulfate (a selective blocker of cholinergic receptors), regitine (a selective blocker of alpha-adrenergic receptors) or DL-propranolol (a selective blocker of \u03b2-adrenergic receptors). However, at 30\u00b0C T<jats:sub>a<\/jats:sub>, systemic administration of Chou-Mou-Li produced no change in rectal temperature or other thermoregulatory responses. On the other hand, direct administration of serotonin into the lateral cerebral ventricle of conscious rats also produced dose-dependent hypothermia at 8 and 22\u00b0C T<jats:sub>a<\/jats:sub>. Again, the hypothermia in response to serotonin was due to decreased metabolism at 8\u00b0C T<jats:sub>a<\/jats:sub> and was due to both decreased metabolism and cutaneous vasodilatation at 22\u00b0C T<jats:sub>a<\/jats:sub>. At 30\u00b0C T<jats:sub>a<\/jats:sub> administration of serotonin also produced no change in thermoregulatory functions. The data indicate that Chou-Mou-Li produces hypothermia by increasing sensible heat loss and decreasing metabolism heat production, probably via the release of endogenous serotonin within brain. <\/jats:p>","DOI":"10.1142\/s0192415x81000184","type":"journal-article","created":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T22:17:30Z","timestamp":1101766650000},"page":"144-154","source":"Crossref","is-referenced-by-count":2,"title":["Serotoninergic Mechanisms of the Hypothermia Induced by <i>Clerodenron Fragrans<\/i> (Ventenaceae) in the Rat"],"prefix":"10.1142","volume":"09","author":[{"given":"Mao-Tsun","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Physiology and Biolphysics, National Defense Medical Center, Taipei, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Ling","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Physiology, Kau-Shium Medical College, Kau-Shium, Taiwan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andi","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biolphysics, National Defense Medical Center, Taipei, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hseng-Kuang","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Physiology, Kau-Shium Medical College, Kau-Shium, Taiwan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"container-title":["The American Journal of Chinese Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0192415X81000184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T20:22:55Z","timestamp":1565122975000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0192415X81000184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2012,4,5]]},"published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1142\/S0192415X81000184"],"URL":"https:\/\/doi.org\/10.1142\/s0192415x81000184","relation":{},"ISSN":["0192-415X","1793-6853"],"issn-type":[{"value":"0192-415X","type":"print"},{"value":"1793-6853","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}