{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T15:58:54Z","timestamp":1649001534709},"reference-count":0,"publisher":"World Scientific Pub Co Pte Lt","issue":"01n04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:p> The effect of safflower on cerebral infarction was studied in 152 Mongolian gerbils. Sixty-three animals were evaluated neurological deficit over 8 hours postoperation, then sacrificed and NE, DA and 5-HT contents of each cerebral hemisphere and brain stem were determined. NE, DA and 5-HT of hemisphere ipsilateral to the ligated artery in untreated animals declined significantly compared with sham-operated animals and safflower-treated gerbils. There was no significant difference between safflower-treated and sham-operated animals in NE, DA and 5-HT contents. The mean stroke index at 8 hours in safflower treated animals was 2.1 \u00b1 0.7, whereas untreated gerbils was 7.8 \u00b1 1.9 ( P &lt; 0.01). Eighty-nine animals were followed up for 5 days, the safflower-treated animals showed a benign clinical course and mortality rate was reduced by 29.7% (6\/34 vs. 26\/55) in safflower-treated animals compared with untreated animals ( P &lt; 0.01). Safflower has a protective and beneficial effect on cerebral ischemia induced in Mongolian gerbils. <\/jats:p>","DOI":"10.1142\/s0192415x83000100","type":"journal-article","created":{"date-parts":[[2004,11,30]],"date-time":"2004-11-30T03:17:30Z","timestamp":1101784650000},"page":"62-68","source":"Crossref","is-referenced-by-count":1,"title":["Cerebral Infarction Improved by Safflower Treatment"],"prefix":"10.1142","volume":"11","author":[{"given":"Pei-gen","family":"Kuang","sequence":"first","affiliation":[{"name":"Research Laboratory of Neurotransmitter, Department of Neurology, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-fu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Research Laboratory of Neurotransmitter, Department of Neurology, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng-yin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Laboratory of Neurotransmitter, Department of Neurology, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen-yang","family":"Lang","sequence":"additional","affiliation":[{"name":"Research Laboratory of Neurotransmitter, Department of Neurology, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zou-lian","family":"Yang","sequence":"additional","affiliation":[{"name":"Research Laboratory of Neurotransmitter, Department of Neurology, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"container-title":["The American Journal of Chinese Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0192415X83000100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T15:19:34Z","timestamp":1565191174000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0192415X83000100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1]]},"references-count":0,"journal-issue":{"issue":"01n04","published-online":{"date-parts":[[2012,4,5]]},"published-print":{"date-parts":[[1983,1]]}},"alternative-id":["10.1142\/S0192415X83000100"],"URL":"https:\/\/doi.org\/10.1142\/s0192415x83000100","relation":{},"ISSN":["0192-415X","1793-6853"],"issn-type":[{"value":"0192-415X","type":"print"},{"value":"1793-6853","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,1]]}}}