{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T15:26:27Z","timestamp":1768922787044,"version":"3.49.0"},"reference-count":0,"publisher":"World Scientific Pub Co Pte Lt","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:p> The pharmacological effects of Anoectochilus formosanus, Ganoderma lucidum and Gynostemma pentaphyllum were studied against carrageenan-induced paw edema and CC1<jats:sub>4<\/jats:sub>-induced hepatotoxicity in rats. The water extracts of G. pentaphyllum and G. lucidum were found to possess significant anti-inflammatory activity against carrageenan induced edema. The administration of Gynostemma pentaphyllum displayed an activity even more potent than indomethacin. In contrast, Anoectochilus formosanus showed a delayed onset of anti-inflammatory activity starting from 4 hrs post carrageenan administration. However, A. formosanus significantly decreased the acute increase in serum GOT and OPT level caused by CC1<jats:sub>4<\/jats:sub>. Histological changes such as necrosis, fatty change, ballooning degeneration, inflammatory infiltration of lymphocytes and Kupffer cells around the central vein were simultaneously improved by the treatment of A. formosanus. <\/jats:p>","DOI":"10.1142\/s0192415x9300008x","type":"journal-article","created":{"date-parts":[[2004,11,30]],"date-time":"2004-11-30T03:17:30Z","timestamp":1101784650000},"page":"59-69","source":"Crossref","is-referenced-by-count":116,"title":["Evaluation of the Anti-inflammatory and Liver-protective Effects of <i>Anoectochilus formosanus<\/i>, <i>Ganoderma lucidum<\/i> and <i>Gynostemma pentaphyllum<\/i> in Rats"],"prefix":"10.1142","volume":"21","author":[{"given":"Jer-Min","family":"Lin","sequence":"first","affiliation":[{"name":"School of Pharmacy, Kaohsiung Medical College, Kaohsiung, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Kaohsiung Medical College, Kaohsiung, Taiwan, ROC"},{"name":"National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Fen","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Kaohsiung Medical College, Kaohsiung, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenq-Jer","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Kaohsiung Medical College, Kaohsiung, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shing-Ginn","family":"Lee","sequence":"additional","affiliation":[{"name":"Taitung District Agricultural Improvement Station, Taitung, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"container-title":["The American Journal of Chinese Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0192415X9300008X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:17:40Z","timestamp":1565137060000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0192415X9300008X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2012,4,5]]},"published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1142\/S0192415X9300008X"],"URL":"https:\/\/doi.org\/10.1142\/s0192415x9300008x","relation":{},"ISSN":["0192-415X","1793-6853"],"issn-type":[{"value":"0192-415X","type":"print"},{"value":"1793-6853","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}