{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T23:12:34Z","timestamp":1648941154108},"reference-count":0,"publisher":"World Scientific Pub Co Pte Lt","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p> To investigate the efficacy of Unsei-in on skin diseases such as Beh\u00e7et's disease, palmoplantar pustulosis and psoriasis vulgaris, the rheological activity of leukocytes as manifested by adhesiveness, deformability and aggregability was studied in vitro using a micropore filtration method. Unsei-in inhibited the rheological activity of leukocytes at a statistical significance of p &lt; 0.01 in normal individuals whose leukocytes had been stimulated with N-formyl-methionyl-leucyl-phenylalanine (FMLP). It did not, however, inhibit the activity of cells that had not been stimulated by FMLP. In contrast, in Beh\u00e7et's disease, Unsei-in inhibited rheological activity of non-stimulated leukocytes ( p &lt; 0.01) but did not inhibit the rheological activity of FMLP-stimulated leukocytes. In a study using Ouren-gedoku-to and Shimotsu-to, the main constituents of Unsei-in, the latter inhibited the activity of FMLP-stimulated leukocytes in normal individuals ( p &lt; 0.02). These results indicate that Unsei-in has an inhibitory effect on rheologically-activated neutrophils, which are involved in the healing mechanisms of the above skin diseases, and it also has a satisfactory effect in the form of a mixture of Shimotsu-to and Ouren-gedoku-to. <\/jats:p>","DOI":"10.1142\/s0192415x95000110","type":"journal-article","created":{"date-parts":[[2004,11,30]],"date-time":"2004-11-30T03:17:30Z","timestamp":1101784650000},"page":"81-90","source":"Crossref","is-referenced-by-count":3,"title":["Unsei-in Inhibits Rheological Activity of Leukocytes: Mechanism of Action in Neutrophil-related Skin Diseases"],"prefix":"10.1142","volume":"23","author":[{"given":"Shigeruko","family":"lijima","sequence":"first","affiliation":[{"name":"Division of Dermatology, Mito Red Cross Hospital, Mito, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fujio","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Instrumentation Research Laboratory, Food Engineering Division, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"container-title":["The American Journal of Chinese Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0192415X95000110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:17:05Z","timestamp":1565137025000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0192415X95000110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2012,4,5]]},"published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1142\/S0192415X95000110"],"URL":"https:\/\/doi.org\/10.1142\/s0192415x95000110","relation":{},"ISSN":["0192-415X","1793-6853"],"issn-type":[{"value":"0192-415X","type":"print"},{"value":"1793-6853","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}