{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:13:41Z","timestamp":1765545221168},"reference-count":0,"publisher":"World Scientific Pub Co Pte Lt","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p> Syh-Mo-Yin (SMY), Guizhi-Fuling-Wan (GFW), Shieh-Qing-Wan (SQW) and Syh-Nih-San (SNS) are prescriptions of Traditional Chinese Medicine (TCM) for liver disease. The effects of these four prescriptions against experimental liver injury induced by \u03b1-Naphthylisothiocyanate (ANIT) and carbon tetrachloride ( CCl <jats:sub>4<\/jats:sub>) were studied. Rats treated with ANIT (100 mg\/kg) exhibited elevations of serum total bilirubin (TBI), alkaline phosphatase (ALP), glutamate-oxalatetransaminase (sGOT) and glutamate-pyruvate-transaminase (sGPT) as well as cholestasis and parenchymanecrosis. In rats receiving SMY, SQW and SNS treatment after ANIT challenged, the biochemical and morphological parameters of liver injury were significantly reduce. Elevated lipid peroxidation (LPO) level in liver tissue, associated with an increase in serum GOT and GPT level, was observed in CCl <jats:sub>4<\/jats:sub>-treated rats. Treatment with these four prescriptions on CCl <jats:sub>4<\/jats:sub>-induced liver injury rats showed a remarkable hepatoprotective effect. A significant decrease in peroxidative level suggested that these prescriptions have anti free radical properties. <\/jats:p>","DOI":"10.1142\/s0192415x97000226","type":"journal-article","created":{"date-parts":[[2003,12,29]],"date-time":"2003-12-29T04:12:42Z","timestamp":1072671162000},"page":"185-196","source":"Crossref","is-referenced-by-count":11,"title":["Ameliorative Effect of Traditional Chinese Medicine Prescriptions on \u03b1-Naphthylisothiocyanate and Carbon-tetrachloride Induced Toxicity in Rats"],"prefix":"10.1142","volume":"25","author":[{"given":"Chin-Chuan","family":"Tsai","sequence":"first","affiliation":[{"name":"Research Institute of Chinese Medicine, China Medical College, 91 Hsueh Shih Road, Taichung, Taiwan, R.O.C"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shung-Te","family":"Kao","sequence":"additional","affiliation":[{"name":"Research Institute of Chinese Medicine, China Medical College, 91 Hsueh Shih Road, Taichung, Taiwan, R.O.C"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Tien","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Pathology, China Medical College, Taichung, China Medical College, Taichung, Taiwan, R.O.C"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Natural Products, Kaohsiung Medical College, Kaohsiung, China Medical College, Taichung, Taiwan, R.O.C"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim-Shoung","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Public Health and Institution of Environmental Health, China Medical College, Taichung, Taiwan, R.O.C"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaung-Geng","family":"Lin","sequence":"additional","affiliation":[{"name":"Research Institute of Chinese Medicine, China Medical College, 91 Hsueh Shih Road, Taichung, Taiwan, R.O.C"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"container-title":["The American Journal of Chinese Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0192415X97000226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T11:16:18Z","timestamp":1565176578000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0192415X97000226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2012,4,5]]},"published-print":{"date-parts":[[1997,1]]}},"alternative-id":["10.1142\/S0192415X97000226"],"URL":"https:\/\/doi.org\/10.1142\/s0192415x97000226","relation":{},"ISSN":["0192-415X","1793-6853"],"issn-type":[{"value":"0192-415X","type":"print"},{"value":"1793-6853","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,1]]}}}