{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T06:02:56Z","timestamp":1744178576143},"reference-count":20,"publisher":"World Scientific Pub Co Pte Lt","issue":"03n04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:p> Han-Dan-Gan-Le, a Chinese medicine preparation composed of Salvia miltorrhiza, Radix paeoniae, Astragalus membranaceus, Stephania tetrandra, and dried leaves of Ginkgo biloba, has been used successfully to treat human liver fibrosis and cirrhosis for years. This study was designed to examine the mechanisms of the protection. Male Wistar rats were given CCI<jats:sub>4<\/jats:sub> (1.2 ml\/kg, 2 times\/week), 20% fat diet, and 30% alcohol in drinking water (every other day) for 6 weeks. Han-Dan-Gan-Le (0.5 and 1.0 g\/kg, p.o., daily for 6 weeks) was administered to rats simultaneously to examine the protective effects against CCl<jats:sub>4<\/jats:sub>-induced liver fibrosis. The experimentally-induced liver fibrosis and other morphological alterations were significantly ameliorated by Han-Dan-Gan-Le. Han-Dan-Gan-Le treatments decreased CCl<jats:sub>4<\/jats:sub>-induced hepatic collagen accumulation by more than 50%, and significantly increased urinary excretion of hydroxyproline. The CCl<jats:sub>4<\/jats:sub>-induced lipid peroxidation in liver and serum was ameliorated as a result of Han-Dan-Gan-Le treatment, possibly by restoring the activity of superoxide dismutase activity in liver and erythrocytes, In conclusion, Han-Dan-Gan-Le is effective in protecting against liver fibrosis. The mechanisms of the protection appear to be due to its antioxidant properties and the modulation of hepatic collagen metabolism. <\/jats:p>","DOI":"10.1142\/s0192415x98000361","type":"journal-article","created":{"date-parts":[[2003,12,23]],"date-time":"2003-12-23T09:08:36Z","timestamp":1072170516000},"page":"325-332","source":"Crossref","is-referenced-by-count":16,"title":["The Protective Effects of Traditional Chinese Medicine Prescription, Han-Dan-Gan-Le, on CCl<sub>4<\/sub>-induced Liver Fibrosis in Rats"],"prefix":"10.1142","volume":"26","author":[{"given":"Cheng-Xiu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Guiyang Medical College, Guiyang, Guizhou 550004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Guiyang Medical College, Guiyang, Guizhou 550004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Guiyang Medical College, Guiyang, Guizhou 550004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Xiou","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Guiyang Medical College, Guiyang, Guizhou 550004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Wen","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Guiyang Medical College, Guiyang, Guizhou 550004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Guiyang Medical College, Guiyang, Guizhou 550004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Guiyang Medical College, Guiyang, Guizhou 550004, China"},{"name":"Department of Pharmacology, University of Kansas Medical Center, Kansas City, KS 66160, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Guiyang Medical College, Guiyang, Guizhou 550004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Len-Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Guiyang Medical College, Guiyang, Guizhou 550004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0920103"},{"key":"p_2","first-page":"300","volume":"15","author":"Cheng M-L","year":"1995","journal-title":"Chin. 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