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The fractions (n-hexane, CHCI<jats:sub>3<\/jats:sub>, EtOAc, n-BuOH, and H<jats:sub>2<\/jats:sub>O) displayed significant inhibitory activity against carrageenan-induced edema, and the active anti-inflammatory components were further localized in the n-BuOH fraction, which exhibited the greatest anti-inflammatory effect, an effect 5% greater than indomethacin (which was used as a standard reference substance). Each fraction exerted a significant hepatoprotective effect by reducing enzymatic alteration (sGOT and sGPT) and by improving hepatic lesions, including liver centrilobular inflammation, cell necrosis, fatty change, ballooning degeneration in CCl<jats:sub>4<\/jats:sub>-induced acute hepatitis; and necrosis of the portal area in D-GalN-induced acute liver injury. The n-BuOH and EtOAc fractions had the greatest hepatoprotective effects on CCl<jats:sub>4<\/jats:sub>)-induced liver injury; in contrast, the CHCI<jats:sub>3<\/jats:sub>) fraction was most potent against D-GalN intoxication, which is comparable to silymarin, as a recognized hepatoprotective drug. <\/jats:p>","DOI":"10.1142\/s0192415x99000264","type":"journal-article","created":{"date-parts":[[2003,11,10]],"date-time":"2003-11-10T05:00:55Z","timestamp":1068440455000},"page":"227-239","source":"Crossref","is-referenced-by-count":13,"title":["The Anti-inflammatory and Hepatoprotective Effects of Fractions from <i>Cudrania cochinchinensis<\/i> var. <i>gerontogea<\/i>"],"prefix":"10.1142","volume":"27","author":[{"given":"Chun-Ching","family":"Lin","sequence":"first","affiliation":[{"name":"School of Pharmacy, Kaohsiung Medical College, Kaohsiung, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiang-Yu","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Kaohsiung Medical College, Kaohsiung, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Hsiung","family":"Chang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chia Nan College of Pharmacy and Science, Tainan Hsien, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenq-Jer","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chia Nan College of Pharmacy and Science, Tainan Hsien, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"issue":"4","key":"p_2","first-page":"377","volume":"47","author":"Chanag C.H.","year":"1993","journal-title":"Shoyakugaku Zasshi"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X88000194"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X89000048"},{"key":"p_5","first-page":"104","volume":"8","author":"Clawson G.A","year":"1989","journal-title":"Res."},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1971.tb07124.x"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711040103"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(68)90103-9"},{"key":"p_9","first-page":"34","author":"Hsu H.Y","year":"1972","journal-title":"R. 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