{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T09:05:58Z","timestamp":1745658358494},"reference-count":4,"publisher":"World Scientific Pub Co Pte Lt","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hand Surg."],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p> The purpose of this study was to compare the initial and final outcome range of motion in the MCP-J and PIP-J of single digit Dupuytren's Contracture treated with either open surgical excision or manipulation after collagenase clostridium histolyticum (CCH; Xiapex) injection. Material: Ten patients in either group. The range of motion measurements were statistically compared using the student t-test with a p-value of 0.05. There was no statistical difference in the pre-treatment status of the total active range of movement (TAM) between the two groups. Results: Open surgical release achieved a statistically better initial outcome in combined total passive range of movement than the xiapex group (p = 0.0047), but at the final outcome the better TAM measurement at the MCP-J after surgery was not statistically significant. However, the total active range of movement was statistically better at the PIP-J level in the xiapex group (p = 0.01) and the MCP-J and PIP-J combined total active range of movement was statistically better in the xiapex group (p = 0.0258). Conclusion: Surgery achieved better initial outcome at both MCP-J and PIP-J levels, and at discharge, only extension in the MCP-J level was statistically better after open excision. However the final outcome was statistically better at the PIP-J level in extension (p = 0.006) and total active movement (TAM) (p = 0.008) after treatment with collagenase clostridium histolyticum. Further studies are required to assess the long-term differences between the two groups and to investigate the outcomes for patients with multi-digit involvement. <\/jats:p>","DOI":"10.1142\/s0218810414500324","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T03:52:36Z","timestamp":1409025156000},"page":"389-392","source":"Crossref","is-referenced-by-count":10,"title":["WHAT IS THE BETTER TREATMENT FOR SINGLE DIGIT DUPUYTREN'S CONTRACTURE: SURGICAL RELEASE OR COLLAGENASE CLOSTRIDIUM HISTOLYTICUM (XIAPEX) INJECTION?"],"prefix":"10.1142","volume":"19","author":[{"given":"Bo","family":"Povlsen","sequence":"first","affiliation":[{"name":"London Hand Clinic, London Bridge Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian D.","family":"Povlsen","sequence":"additional","affiliation":[{"name":"St Catherine's College, University of Oxford, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2014,10,6]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193410397971"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.2000.6918"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2012.10.008"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2012.09.028"}],"container-title":["Hand Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0218810414500324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T12:08:15Z","timestamp":1565093295000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0218810414500324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":4,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2014,10,6]]},"published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1142\/S0218810414500324"],"URL":"https:\/\/doi.org\/10.1142\/s0218810414500324","relation":{},"ISSN":["0218-8104","1793-6535"],"issn-type":[{"value":"0218-8104","type":"print"},{"value":"1793-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}