{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:18:08Z","timestamp":1762899488740},"reference-count":11,"publisher":"World Scientific Pub Co Pte Lt","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hand Surg Asian-Pac Vol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p> Background: Synthetic scaffold has been used for tissue approximation and reconstructing damaged and torn ligaments. This study explores the ability of tendon ingrowth into a synthetic scaffold in vitro, evaluate growth characteristics, morphology and deposition of collagen matrix into a synthetic scaffold. <\/jats:p><jats:p> Methods: Upper limb tendons were harvested with consent from patients with crush injuries and non-replantable amputations. These tendons (both extensor and flexor) measuring 1 cm are sutured to either side of a 0.5 cm synthetic tendon strip and cultured in growth medium. At 2, 4, 6 and 8 weeks, samples were fixed into paraffin blocks, cut and stained with haematoxylin-eosin (H&amp;E) and Masson\u2019s trichrome. <\/jats:p><jats:p> Results: Minimal tendon ingrowth were seen in the first 2 weeks of incubation. However at 4 weeks, the cell ingrowth were seen migrating towards the junction between the tendon and the synthetic scaffold. This ingrowth continued to expand at 6 weeks and up to 8 weeks. At this point, the demarcation between human tendon and synthetic scaffold was indistinct. <\/jats:p><jats:p> Conclusions: We conclude that tendon ingrowth composed of collagen matrix were able to proliferate into a synthetic scaffold in vitro. <\/jats:p>","DOI":"10.1142\/s0218810417500459","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T04:36:25Z","timestamp":1510202185000},"page":"429-434","source":"Crossref","is-referenced-by-count":4,"title":["In Vitro Evaluation of Human Hand Tendon Ingrowth into A Synthetic Scaffold"],"prefix":"10.1142","volume":"22","author":[{"given":"Shalimar","family":"Abdullah","sequence":"first","affiliation":[{"name":"Hand and Microsurgery Unit, Department of Orthopaedics and Traumatology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadzlina","family":"Mohtar","sequence":"additional","affiliation":[{"name":"Hand and Microsurgery Unit, Department of Orthopaedics and Traumatology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nordashima","family":"Abdul Shukor","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamari","family":"Sapuan","sequence":"additional","affiliation":[{"name":"Hand and Microsurgery Unit, Department of Orthopaedics and Traumatology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1586\/17434440.6.1.61"},{"issue":"8","key":"p_2","first-page":"353","volume":"7","author":"El-Hussiney I","year":"2011","journal-title":"J of Am Science."},{"key":"p_6","first-page":"173","year":"1993","journal-title":"London: Butterworth Heinemann"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.71B4.2768298"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1615\/JLongTermEffMedImplants.v16.i1.50"},{"issue":"3","key":"p_9","first-page":"515","volume":"180","author":"Strocchi R","year":"1992","journal-title":"J Anat."},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.07.053"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-008-0608-9"},{"issue":"3","key":"p_12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1302\/0301-620X.84B3.11559","volume":"84","author":"Jennings AG","year":"2002","journal-title":"J Bone Joint Surg Br."},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.73B3.1670431"},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2008.00864.x"}],"container-title":["The Journal of Hand Surgery (Asian-Pacific Volume)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0218810417500459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T09:35:46Z","timestamp":1565170546000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0218810417500459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,9]]},"references-count":11,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2017,11,9]]},"published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1142\/S0218810417500459"],"URL":"https:\/\/doi.org\/10.1142\/s0218810417500459","relation":{},"ISSN":["2424-8355","2424-8363"],"issn-type":[{"value":"2424-8355","type":"print"},{"value":"2424-8363","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,9]]}}}