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Two additional, biologically distinct patient relationships also replicated, linking IL-6\/JAK\/STAT3 state to apoptosis-cholesterol coordination and IFN-gamma state to EMT-IFN-alpha coordination, without implying a shared molecular mechanism. Thirty-two patient relationships survived structural checks and five replicated in the same direction. Cell-line analyses provided complementary constraints: CRISPR tested selective single-gene dependency associations, whereas GDSC tested preclinical drug-response associations. None of 895,224 valid CRISPR axis-gene tests survived global correction, whereas four of 31,610 GDSC axis-drug tests did, on NOTCH, Complement, or Apoptosis axes; three involved MEK1\/2 inhibitors. These drug-response associations do not validate the patient correlations, but they motivate prospective testing of pathway states as preclinical stratification variables. 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