{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:38:16Z","timestamp":1777264696268,"version":"3.51.4"},"reference-count":15,"publisher":"World Scientific Pub Co Pte Ltd","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nano LIFE"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:p>\n                    A recent Nature Neuroscience paper by Marutani and colleagues makes the striking claim that chronic hypoxia can reverse or even halt the progression of Parkinson\u2019s disease (PD), based on findings in an [Formula: see text]-synuclein pre-formed fibril (PFF) mouse model.\n                    <jats:sup>1<\/jats:sup>\n                    While the concept is provocative, the study is riddled with critical methodological and interpretive flaws. First, the disease model fails to reflect the multifactorial and progressive reality of human PD. Second, the intervention\u2013 sustained exposure to 11% oxygen \u2014 is neither safe nor clinically translatable, and its reported benefits may stem from non-specific stress adaptation rather than targeted neuroprotection. Third, mechanistic assertions lack causal validation, and behavioral improvements are tenuously linked to neuronal function. This correspondence urges caution in interpreting such findings and warns against premature enthusiasm for hypoxia-based therapies in PD. The work exemplifies a growing problem in biomedical research: eye-catching, media-ready conclusions that race ahead of the data\u2019s rigor and clinical relevance.\n                  <\/jats:p>","DOI":"10.1142\/s1793984425750017","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T08:09:51Z","timestamp":1760429391000},"source":"Crossref","is-referenced-by-count":1,"title":["Hypoxia and Parkinson\u2019s Disease: A Dangerous Oversimplification Based on a Subpar Mouse Model"],"prefix":"10.1142","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4986-8444","authenticated-orcid":false,"given":"Martin","family":"Yarmush","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"S1793984425750017BIB001","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-025-02010-4"},{"key":"S1793984425750017BIB002","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00621"},{"key":"S1793984425750017BIB003","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-023-03277-5"},{"key":"S1793984425750017BIB004","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18041692"},{"key":"S1793984425750017BIB005","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1191058"},{"key":"S1793984425750017BIB006","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-051777"},{"key":"S1793984425750017BIB007","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2015.08.004"},{"key":"S1793984425750017BIB008","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.7.990"},{"key":"S1793984425750017BIB009","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-023-02724-y"},{"key":"S1793984425750017BIB010","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9050468"},{"key":"S1793984425750017BIB011","unstructured":"PubMed, Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson\u2019s disease [Conflict of Interest Statement], https:\/\/pubmed.ncbi.nlm.nih.gov\/40770507(accessed on August 20, 2025)."},{"key":"S1793984425750017BIB012","unstructured":"Harvard Medical School, Breathing low-oxygen air improves Parkinson\u2019s symptoms in mice, https:\/\/hms.harvard.edu\/news\/breathing-low-oxygen-air-improves-parkinsons-symptoms-mice(accessed on August 20, 2025)."},{"key":"S1793984425750017BIB013","unstructured":"Broad Institute, Breathing low-oxygen air slows Parkinson\u2019s progression in mice, https:\/\/www.broadinstitute.org\/news\/breathing-low-oxygen-air-slows-parkinsons-progression-mice(accessed on August 20, 2025)."},{"key":"S1793984425750017BIB014","unstructured":"SciTechDaily, Mount Everest air offers clues to Parkinson\u2019s treatment, https:\/\/scitechdaily.com\/mount-everest-air-offers-clues-to-parkinsons-treatment(accessed on August 20, 2025)."},{"key":"S1793984425750017BIB015","unstructured":"Genetic Engineering n Biotechnology News, Out of thin air: Hypoxia reverses Parkinson\u2019s symptoms in mice, https:\/\/www.genengnews.com\/topics\/drug-discovery\/out-of-thin-air-hypoxia-reverses-parkinsons-symptoms-in-mice(accessed on August 20, 2025)."}],"container-title":["Nano LIFE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S1793984425750017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T03:54:26Z","timestamp":1777262066000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/10.1142\/S1793984425750017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,14]]},"references-count":15,"journal-issue":{"issue":"06","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10.1142\/S1793984425750017"],"URL":"https:\/\/doi.org\/10.1142\/s1793984425750017","relation":{},"ISSN":["1793-9844","1793-9852"],"issn-type":[{"value":"1793-9844","type":"print"},{"value":"1793-9852","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,14]]},"article-number":"2575001"}}