{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:09:27Z","timestamp":1787314167942,"version":"build-2736575974"},"reference-count":0,"publisher":"World Scientific Pub Co Pte Ltd","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hand Surg Asian-Pac Vol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>Background: The etiology and natural history of Kienb\u00f6ck\u2019s disease remain unclear. Traditionally it has been defined as avascular necrosis of the lunate. The authors tried to demonstrate different tissue distribution, the area ratio of necrotic tissue and vessel counts inside the whole Kienb\u00f6ck lunate to reveal a dynamic process of the lunate collapse.<\/jats:p>\n                  <jats:p>Methods: Five lunates from patients with stage III Kienb\u00f6ck\u2019s disease and one cadaveric lunate not involved by Kienb\u00f6ck\u2019s disease were sampled. They were sectioned, H&amp;E stained, and evaluated. The thickness of trabecular bone and the area of necrotic tissue were measured with Image-Pro Plus. The number of vessels was counted manually.<\/jats:p>\n                  <jats:p>Results: In the normal lunate, the bone trabeculae showed a uniform distribution with fatty marrow filled the interspace between the trabeculae. In the lunates with Kienb\u00f6ck disease, the trabeculae fracture and necrosis located in the central part with massive fibrous granular tissue proliferation. There were also some chondroid metaplasia at the palmar and dorsal ends. The trabeculae of the lunates of the Kienb\u00f6ck\u2019s disease [0.188 mm (0.153 mm, 0.236 mm)] was significantly thicker than the normal lunates [0.146 mm (0.124 mm, 0.164 mm)]. The necrosis was localized around the fracture sites instead of the whole lunate. The mean necrosis area only accounts for 16.3% \u00b1 8.9% of the whole section. Such kind of focal necrosis is quite similar to those around the traumatic fracture ends of other bones. Even in stage III Kienb\u00f6ck lunates, the vessels are quite abundant (221 \u00b1 42 in one sagittal section), while the vessels inside the normal lunate were 352 \u00b1 28.<\/jats:p>\n                  <jats:p>Conclusions: There is neither massive nor obvious generalized avascular bone necrosis in our histopathology observations. The focal necrosis and vessel damage were more likely associated with the broken trabeculae inside the lunate. Based on our histopathology observations, we suggested that the progressive process of Kienb\u00f6ck\u2019s disease could be described as lunate nonunion advanced collapse instead of avascular necrosis.<\/jats:p>","DOI":"10.1142\/s2424835521500284","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T23:50:43Z","timestamp":1620345043000},"page":"333-338","source":"Crossref","is-referenced-by-count":3,"title":["Histopathology Findings of the Lunate in Stage III Kienb\u00f6ck\u2019s Disease"],"prefix":"10.1142","volume":"26","author":[{"given":"Ge","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Hand Surgery, Beijing Jishuitan Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beijing Jishuitan Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beijing Jishuitan Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2021,8,10]]},"container-title":["The Journal of Hand Surgery (Asian-Pacific Volume)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S2424835521500284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T02:01:16Z","timestamp":1628733676000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S2424835521500284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,10]]},"references-count":0,"journal-issue":{"issue":"03","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1142\/S2424835521500284"],"URL":"https:\/\/doi.org\/10.1142\/s2424835521500284","relation":{},"ISSN":["2424-8355","2424-8363"],"issn-type":[{"value":"2424-8355","type":"print"},{"value":"2424-8363","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,10]]}}}