{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T18:23:33Z","timestamp":1759602213154},"reference-count":9,"publisher":"World Scientific Pub Co Pte Ltd","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hand Surg Asian-Pac Vol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p> Laurin\u2013Sandrow syndrome (LSS) is an extremely rare syndrome of mirror hand and leg with less than 20 cases reported in literature. The syndrome has been attributed to a mutation in the MIPOL-1 (mirror-image polydactyly) gene located on locus 14q13.3-q21 coding for CCDC193 (coiled-coli domain containing 193) protein. It is characterised by limb, facial and central nervous system anomalies with the most constant being fibular dimelia with fibular ray duplication, polydactyly with secondary deformities of fixed equinus, knee joint instability and flexion deformity. It is associated less frequently with ulnar dimelia, thumb aplasia\/hypoplasia, ulnar ray duplication, symbrachypolydactyly, \u2018rosette\u2019 hands, facial dysmorphism like hypertelorism, broad columella and flat nose, CNS anomalies like aplasia\/hypoplasia of corpus callosum, hydrocephalus and muscular dystonia. We report a 2-year-old male child with LSS and perform a literature review to expound on this rare syndrome. <\/jats:p><jats:p> Level of Evidence: Level V (Therapeutic) <\/jats:p>","DOI":"10.1142\/s2424835522720389","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T04:04:37Z","timestamp":1660536277000},"page":"742-746","source":"Crossref","is-referenced-by-count":1,"title":["Laurin\u2013Sandrow Syndrome: A Case Report and Review of Literature"],"prefix":"10.1142","volume":"27","author":[{"given":"Kanagasabai","family":"SATHISHKUMAR","sequence":"first","affiliation":[{"name":"Institute for Research and Rehabilitation of Hand & Department of Plastic Surgery, Govt Stanley Medical College & Hospital, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"ANAND","sequence":"additional","affiliation":[{"name":"Institute for Research and Rehabilitation of Hand & Department of Plastic Surgery, Govt Stanley Medical College & Hospital, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"key":"S2424835522720389BIB001","first-page":"323.","volume":"2013","author":"Vasluian E","journal-title":"BMC Musculoskelet Disord"},{"key":"S2424835522720389BIB002","doi-asserted-by":"publisher","DOI":"10.1111\/cga.12154"},{"key":"S2424835522720389BIB004","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32393"},{"key":"S2424835522720389BIB005","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320590312"},{"key":"S2424835522720389BIB006","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4897"},{"key":"S2424835522720389BIB007","doi-asserted-by":"publisher","DOI":"10.1007\/s100380200015"},{"key":"S2424835522720389BIB008","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12352"},{"key":"S2424835522720389BIB009","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320460205"},{"key":"S2424835522720389BIB010","first-page":"134","volume":"7","author":"Woiczik MR","year":"2018","journal-title":"UNM Orthop Res J"}],"container-title":["The Journal of Hand Surgery (Asian-Pacific Volume)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S2424835522720389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T03:49:16Z","timestamp":1665373756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/10.1142\/S2424835522720389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":9,"journal-issue":{"issue":"04","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1142\/S2424835522720389"],"URL":"https:\/\/doi.org\/10.1142\/s2424835522720389","relation":{},"ISSN":["2424-8355","2424-8363"],"issn-type":[{"value":"2424-8355","type":"print"},{"value":"2424-8363","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8]]}}}