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However, the difficulty in comparing outcomes across various treatments is likely to persist due to limitations in evaluating the effectiveness of those treatments. Patient-reported outcome measures may not accurately reflect disease severity or treatment success; objective measures might not correlate well with subjective improvements and treating all joints with equal weight is unrealistic. Additionally, the inherent difficulties of blinding in studies comparing surgical and percutaneous techniques, along with heterogeneity of the affected population, further complicate outcome assessment. There are interesting developments in the basic science arena resulting in a deeper understanding of the signalling pathways driving DD. Targeting molecular targets early in the signalling pathway may hold the key to preventing pathological contractures in Dupuytren patients. <\/jats:p><jats:p> Level of Evidence: Level V (Therapeutic) <\/jats:p>","DOI":"10.1142\/s2424835525400041","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T01:11:13Z","timestamp":1752541873000},"page":"358-366","source":"Crossref","is-referenced-by-count":0,"title":["Dupuytren Disease from Past to Present: A Review of the Historical and Evolving Landscape of Its Management"],"prefix":"10.1142","volume":"30","author":[{"given":"Zhixue","family":"LIM","sequence":"first","affiliation":[{"name":"Department of Hand & Reconstructive Microsurgery, National University Health System, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alphonsus Khin Sze","family":"CHONG","sequence":"additional","affiliation":[{"name":"Department of Hand & Reconstructive Microsurgery, National University Health 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