{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T16:22:59Z","timestamp":1772554979305,"version":"3.50.1"},"reference-count":39,"publisher":"World Scientific Pub Co Pte Lt","issue":"01","funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["SFRH\/BPD\/109574\/2015"],"award-info":[{"award-number":["SFRH\/BPD\/109574\/2015"]}]},{"name":"the Research Project","award":["UID\/Multi\/04621\/2013"],"award-info":[{"award-number":["UID\/Multi\/04621\/2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Mech. Med. Biol."],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p> Aortic dilation is associated with congenital bicuspid aortic valve (BAV) disease, and its etiology is still not completely understood. The aim of this study is to provide further insight into aortic hemodynamics in a BAV population with different degrees of aortic dilation and regurgitation in comparison with a patient without pathology. A fluid\u2013structure interaction (FSI) numerical approach is implemented regarding patient-specific geometries, where the aortic valves are defined by analytical orifices. Results show that, while the patient without pathology displays a typical hemodynamic behavior of flows in bends, BAV-related aortas present an accelerated flow along the outer aortic wall. Wall shear stress (WSS) overload in the outer curvature is observed, more marked in more dilated aortas. Moreover, helices in the ascending aorta are present in these patients, enhanced with greater dilation. These findings support the fact that hemodynamic factors play an important role in aortic dilation onset and development in BAV patients, caused by a prolonged exposure of the outer ascending aortic curvature to altered WSS. Besides, our results suggest that greater aortic regurgitation may be associated with abnormal WSS distributions in the ascending aorta during diastole, which can facilitate aortic root dilation. <\/jats:p>","DOI":"10.1142\/s0219519419500684","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T15:43:38Z","timestamp":1581608618000},"page":"1950068","source":"Crossref","is-referenced-by-count":7,"title":["NUMERICAL SIMULATION OF DILATION PATTERNS OF THE ASCENDING AORTA IN AORTOPATHIES"],"prefix":"10.1142","volume":"20","author":[{"given":"DIANA C.","family":"OLIVEIRA","sequence":"first","affiliation":[{"name":"Department of Bioengineering and CEMAT, Instituto Superior T\u00e9cnico, Ulisboa Av. 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