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This paper summarizes our recent contribution to the synthesis of stable amphiphilic halogenated meso-tetraarylbacteriochlorins. Their photophysics, in vitro cytotoxicity and phototoxicity are presented and their potential use as photosensitizer for PDT application is assessed.<\/jats:p>","DOI":"10.1142\/s1088424609000553","type":"journal-article","created":{"date-parts":[[2009,7,20]],"date-time":"2009-07-20T03:52:17Z","timestamp":1248061937000},"page":"567-573","source":"Crossref","is-referenced-by-count":36,"title":["Synthesis and photophysical properties of amphiphilic halogenated bacteriochlorins: new opportunities for photodynamic therapy of cancer"],"prefix":"10.1142","volume":"13","author":[{"given":"Mariette M.","family":"Pereira","sequence":"first","affiliation":[{"name":"Chemistry Department, Rua Larga, University of Coimbra, 3004-595 Coimbra, Portugal"}]},{"given":"Carlos J.P.","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Chemistry Department, Rua Larga, University of Coimbra, 3004-595 Coimbra, Portugal"}]},{"given":"Ana V.C.","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Chemistry Department, Rua Larga, University of Coimbra, 3004-595 Coimbra, Portugal"}]},{"given":"Sara M.A.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Chemistry Department, Rua Larga, University of Coimbra, 3004-595 Coimbra, Portugal"}]},{"given":"Lu\u00eds G.","family":"Arnaut","sequence":"additional","affiliation":[{"name":"Chemistry Department, Rua Larga, University of Coimbra, 3004-595 Coimbra, Portugal"}]},{"given":"Gon\u00e7alo F.F.","family":"S\u00e1","sequence":"additional","affiliation":[{"name":"Chemistry Department, Rua Larga, University of Coimbra, 3004-595 Coimbra, Portugal"}]},{"given":"Elsa F.F.","family":"Silva","sequence":"additional","affiliation":[{"name":"Chemistry Department, Rua Larga, University of Coimbra, 3004-595 Coimbra, Portugal"}]},{"given":"Lu\u00eds B.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Bluepharma SA, S\u00e3o Martinho do Bispo, 4045-016 Coimbra, Portugal"}]},{"given":"S\u00e9rgio","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Bluepharma SA, S\u00e3o Martinho do Bispo, 4045-016 Coimbra, Portugal"}]},{"given":"Sebasti\u00e3o J.","family":"Formosinho","sequence":"additional","affiliation":[{"name":"Chemistry Department, Rua Larga, University of Coimbra, 3004-595 Coimbra, Portugal"}]}],"member":"219","published-online":{"date-parts":[[2012,4,8]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2003.10.002"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1016\/S1572-1000(04)00007-9"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.2174\/092986708784872401"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.02.012"},{"key":"rf5","doi-asserted-by":"crossref","DOI":"10.1201\/9781482296952","volume-title":"Chemical Aspects of Photodynamic Therapy","author":"Bonnett R.","year":"2000"},{"key":"rf6","volume-title":"The Fundamental Bases of Phototherapy","author":"Berg K.","year":"1996"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2007.00073.x"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2004.07.011"},{"key":"rf9","doi-asserted-by":"publisher","DOI":"10.1021\/jo060041z"},{"key":"rf10","doi-asserted-by":"publisher","DOI":"10.2174\/1385272043370131"},{"key":"rf11","doi-asserted-by":"publisher","DOI":"10.1021\/jo050467y"},{"key":"rf12","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3765(19981102)4:11<2299::AID-CHEM2299>3.0.CO;2-H"},{"key":"rf13","doi-asserted-by":"publisher","DOI":"10.1021\/bc070092i"},{"key":"rf14","doi-asserted-by":"publisher","DOI":"10.1021\/jm050919z"},{"key":"rf15","doi-asserted-by":"publisher","DOI":"10.1021\/ja046210j"},{"key":"rf16","first-page":"1011","volume":"11","author":"Callot H. 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