{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T04:41:42Z","timestamp":1750308102634,"version":"3.41.0"},"publisher-location":"New York, NY, USA","reference-count":21,"publisher":"ACM","license":[{"start":{"date-parts":[[2005,6,25]],"date-time":"2005-06-25T00:00:00Z","timestamp":1119657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.acm.org\/publications\/policies\/copyright_policy#Background"}],"content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,6,25]]},"DOI":"10.1145\/1068009.1068339","type":"proceedings-article","created":{"date-parts":[[2005,8,3]],"date-time":"2005-08-03T08:31:47Z","timestamp":1123057907000},"page":"1969-1976","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The molecule evoluator"],"prefix":"10.1145","author":[{"given":"Eric-Wubbo","family":"Lameijer","sequence":"first","affiliation":[{"name":"Leiden University, Leiden, the Netherlands"}]},{"given":"Ad","family":"IJzerman","sequence":"additional","affiliation":[{"name":"Leiden University, Leiden, the Netherlands"}]},{"given":"Joost","family":"Kok","sequence":"additional","affiliation":[{"name":"Leiden University, Leiden, the Netherlands"}]}],"member":"320","published-online":{"date-parts":[[2005,6,25]]},"reference":[{"key":"e_1_3_2_1_1_1","volume-title":"Handbook of Evolutionary Computation","author":"Banzhaf W.","year":"1997","unstructured":"Banzhaf , W. Interactive Evolution . In B\u00e4ck, T., Fogel D.B., Michalewicz, Z. (Eds.), Handbook of Evolutionary Computation , Oxford University Press, New York , and Institute of Physics Publishing , Bristol, 1997 . Banzhaf, W. Interactive Evolution. In B\u00e4ck, T., Fogel D.B., Michalewicz, Z. (Eds.), Handbook of Evolutionary Computation, Oxford University Press, New York, and Institute of Physics Publishing, Bristol, 1997."},{"key":"e_1_3_2_1_2_1","volume-title":"San Francisco CA","author":"Banzhaf W.","year":"1998","unstructured":"Banzhaf , W. , Nordin P. , Keller , R.E. , and Francone , F.D . Genetic Programming-An Introduction. Morgan-Kaufmann , San Francisco CA , 1998 . Banzhaf, W., Nordin P., Keller, R.E., and Francone, F.D. Genetic Programming-An Introduction. Morgan-Kaufmann, San Francisco CA, 1998."},{"key":"e_1_3_2_1_3_1","volume-title":"Evolutionary Design by Computers","author":"Bentley P.J.","year":"1999","unstructured":"Bentley , P.J. Evolutionary Design by Computers , Morgan Kaufmann Publishers , San Francisso, CA , 1999 . Bentley, P.J. Evolutionary Design by Computers, Morgan Kaufmann Publishers, San Francisso, CA, 1999."},{"key":"e_1_3_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci034290p"},{"key":"e_1_3_2_1_5_1","first-page":"18","article-title":"Health care","volume":"2004","author":"Class S","unstructured":"Class , S . Health care in Focus. Chemical & Engineering News, Dec 6th 2004 , 18 -- 29 . Class, S. Health care in Focus. Chemical & Engineering News, Dec 6th 2004, 18--29.","journal-title":"Focus. Chemical & Engineering News, Dec 6th"},{"key":"e_1_3_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci00007a012"},{"key":"e_1_3_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-6296(02)00126-1"},{"key":"e_1_3_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008108423895"},{"key":"e_1_3_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00124408"},{"key":"e_1_3_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/10\/3\/312"},{"key":"e_1_3_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021928016359"},{"key":"e_1_3_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja963036t"},{"key":"e_1_3_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(96)00423-1"},{"key":"e_1_3_2_1_14_1","volume-title":"Genetic Programming 1998: Proceedings of the Third Annual Conference","author":"Nachbar R.B.","year":"1998","unstructured":"Nachbar , R.B. Molecular Evolution: A Hierarchical Representation for Chemical Topology and Its Automated Manipulation . In Genetic Programming 1998: Proceedings of the Third Annual Conference (University of Wisconsin, Madison, Wisconsin , July 22-25, 1998 ). Morgan Kaufmann , San Francisco, CA, 1998, 246--253. Nachbar, R.B. Molecular Evolution: A Hierarchical Representation for Chemical Topology and Its Automated Manipulation. In Genetic Programming 1998: Proceedings of the Third Annual Conference (University of Wisconsin, Madison, Wisconsin, July 22-25, 1998). Morgan Kaufmann, San Francisco, CA, 1998, 246--253."},{"key":"e_1_3_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014389729000"},{"key":"e_1_3_2_1_16_1","volume-title":"Big pharma learns how to love IT. Scientific Computing World","author":"Rees P.","year":"2003","unstructured":"Rees , P. Big pharma learns how to love IT. Scientific Computing World ( 2003 ), 16--18. Rees, P. Big pharma learns how to love IT. Scientific Computing World (2003), 16--18."},{"key":"e_1_3_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20001117)39:22<4130::AID-ANIE4130>3.0.CO;2-E"},{"key":"e_1_3_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci049782w"},{"key":"e_1_3_2_1_19_1","first-page":"2765","volume":"46","author":"Vinkers M.H.","year":"2003","unstructured":"Vinkers , M.H. , De Jonge , M.R. , Daeyaert , F.F.D. , Heeres , J. , Koymans , L.M.H. , Van Lenthe , J.H. , Lewi , P.J. , Timmerman , H. , Van Aken , K. , and Janssen , P.A . J. SYNOPSIS: SYNthesize and Optimize System in Silico. Journal of Medicinal Chemistry 46 ( 2003 ), 2765 -- 2773 . Vinkers, M.H., De Jonge, M.R., Daeyaert, F.F.D., Heeres, J., Koymans, L.M.H., Van Lenthe, J.H., Lewi, P.J., Timmerman, H., Van Aken, K., and Janssen, P.A.J. SYNOPSIS: SYNthesize and Optimize System in Silico. Journal of Medicinal Chemistry 46 (2003), 2765--2773.","journal-title":"J. SYNOPSIS: SYNthesize and Optimize System in Silico. Journal of Medicinal Chemistry"},{"key":"e_1_3_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci00057a005"},{"key":"e_1_3_2_1_21_1","unstructured":"http:\/\/www.mdli.com\/downloads\/public\/ctfile\/ctfile.jsp  http:\/\/www.mdli.com\/downloads\/public\/ctfile\/ctfile.jsp"}],"event":{"name":"GECCO05: Genetic and Evolutionary Computation Conference","sponsor":["SIGEVO ACM Special Interest Group on Genetic and Evolutionary Computation","ACM Association for Computing Machinery"],"location":"Washington DC USA","acronym":"GECCO05"},"container-title":["Proceedings of the 7th annual conference on Genetic and evolutionary computation"],"original-title":[],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/1068009.1068339","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/1068009.1068339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T16:08:04Z","timestamp":1750262884000},"score":1,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/1068009.1068339"}},"subtitle":["an interactive evolutionary algorithm for designing drug molecules"],"short-title":[],"issued":{"date-parts":[[2005,6,25]]},"references-count":21,"alternative-id":["10.1145\/1068009.1068339","10.1145\/1068009"],"URL":"https:\/\/doi.org\/10.1145\/1068009.1068339","relation":{},"subject":[],"published":{"date-parts":[[2005,6,25]]},"assertion":[{"value":"2005-06-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}