{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T04:32:26Z","timestamp":1750307546040,"version":"3.41.0"},"reference-count":24,"publisher":"Association for Computing Machinery (ACM)","issue":"9","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.acm.org\/publications\/policies\/copyright_policy#Background"}],"content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"short-container-title":["Queue"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>One morning, as Gregorina Samsa was waking up from anxious dreams, she discovered that she had become afflicted with certain mysterious flu-like symptoms that appeared without any warning. Equally irritating, this capricious metamorphosis seemed impervious to a rational explanation in terms of causes and effects. \"What\u2019s happened to me?\" she thought. Before seeing a doctor, she decided to find out more about what might ail her. She logged on to a Web site where she annotated a timeline with what she could remember. Since March, she\u2019d had more headaches than usual, and then in April she had begun to experience more fatigue after exercise, and as of July she had also experienced occasional lapses in memory. \"Why don\u2019t I go back to sleep for a little while longer and forget all this foolishness,\" she thought. As she was about to abandon this errand, the system came back to life with a barrage of questions: Is she female? Had she experienced any significant stress in the past few months? Had she noticed any joint or muscle pain? It also obtained her permission to download her genomic profile.<\/jats:p>","DOI":"10.1145\/1626135.1629775","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T04:27:50Z","timestamp":1599107270000},"page":"40-52","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Metamorphosis: the Coming Transformation of Translational Systems Biology"],"prefix":"10.1145","volume":"7","author":[{"given":"Samantha","family":"Kleinberg","sequence":"first","affiliation":[{"name":"NYU"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bud","family":"Mishra","sequence":"additional","affiliation":[{"name":"New York University's Courant Institute and School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"320","published-online":{"date-parts":[[2009,10]]},"reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1013699998"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0000005"},{"volume-title":"Model Checking","author":"Clarke E.M.","key":"e_1_2_1_3_1","unstructured":"Clarke , E.M. , Grumberg , O. , Peled , D.A. 1999. Model Checking . Cambridge, MA : MIT Press . Clarke, E.M., Grumberg, O., Peled, D.A. 1999. Model Checking. Cambridge, MA: MIT Press."},{"volume-title":"Physical Causation","author":"Dowe P.","key":"e_1_2_1_4_1","unstructured":"Dowe , P. 2000. Physical Causation . Cambridge University Press . Dowe, P. 2000. Physical Causation. Cambridge University Press."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1056397487"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","unstructured":"Eells E. 1991. Probabilistic Causality. Cambridge University Press.  Eells E. 1991. Probabilistic Causality. Cambridge University Press.","DOI":"10.1017\/CBO9780511570667"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1198\/016214504000000089"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1124"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/106652700750050961"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.5555\/2074094.2074111"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01211866"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1198\/016214507000000167"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1471"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11693-008-9014-3"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.2307\/2025310"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1109\/BIBM.2008.82"},{"volume-title":"Modeling gene expression data using dynamic Bayesian networks. Technical report","author":"Murphy K.","key":"e_1_2_1_19_1","unstructured":"Murphy , K. Mian , S. 1999. Modeling gene expression data using dynamic Bayesian networks. Technical report , University of California , Berkeley, CA . Murphy, K. Mian, S. 1999. Modeling gene expression data using dynamic Bayesian networks. Technical report, University of California, Berkeley, CA."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-1-37"},{"key":"e_1_2_1_21_1","volume-title":"Causality: Models, Reasoning, and Inference","author":"Pearl J.","year":"2000","unstructured":"Pearl , J. 2000 . Causality: Models, Reasoning, and Inference . Cambridge University Press . Pearl, J. 2000. Causality: Models, Reasoning, and Inference. Cambridge University Press."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/psaprocbienmeetp.1980.2.192586"},{"volume-title":"Prediction, and Search","author":"Spirtes P.","key":"e_1_2_1_23_1","unstructured":"Spirtes , P. , Glymour , C. , Scheines , R. 2000. Causation , Prediction, and Search . MIT Press . Spirtes, P., Glymour, C., Scheines, R. 2000. Causation, Prediction, and Search. MIT Press."},{"key":"e_1_2_1_24_1","volume-title":"Proceedings of the Atlantic Symposium on Computational Biology, Genome Information Systems and Technology.","author":"Spirtes P.","year":"2001","unstructured":"Spirtes , P. , Glymour , C. , Scheines , R. , Kauffman , S. , Aimale , V. , Wimberly , F. 2001 . Constructing Bayesian network models of gene expression networks from microarray data . Proceedings of the Atlantic Symposium on Computational Biology, Genome Information Systems and Technology. Spirtes, P., Glymour, C., Scheines, R., Kauffman, S., Aimale, V., Wimberly, F. 2001. Constructing Bayesian network models of gene expression networks from microarray data. Proceedings of the Atlantic Symposium on Computational Biology, Genome Information Systems and Technology."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1530509100"},{"key":"e_1_2_1_26_1","unstructured":"Suppes P. 1970. A probabilistic theory of causality. North-Holland.  Suppes P. 1970. A probabilistic theory of causality. North-Holland."}],"container-title":["Queue"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/1626135.1629775","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/1626135.1629775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T12:23:31Z","timestamp":1750249411000},"score":1,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/1626135.1629775"}},"subtitle":["In the future computers will mine patient data to deliver faster, cheaper healthcare, but how will we design them to give informative causal explanations? Ideas from philosophy, model checking, and statistical testing can pave the way for the needed translational systems biology."],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1145\/1626135.1629775"],"URL":"https:\/\/doi.org\/10.1145\/1626135.1629775","relation":{},"ISSN":["1542-7730","1542-7749"],"issn-type":[{"type":"print","value":"1542-7730"},{"type":"electronic","value":"1542-7749"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"2009-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}