{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T04:22:43Z","timestamp":1750306963845,"version":"3.41.0"},"publisher-location":"New York, NY, USA","reference-count":6,"publisher":"ACM","license":[{"start":{"date-parts":[[2013,9,22]],"date-time":"2013-09-22T00:00:00Z","timestamp":1379808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.acm.org\/publications\/policies\/copyright_policy#Background"}],"content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,9,22]]},"DOI":"10.1145\/2506583.2506661","type":"proceedings-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T14:11:56Z","timestamp":1383055916000},"page":"657-658","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["An integrated pharmacogenomic analysis of doxorubicin response using genotype information on DMET genes"],"prefix":"10.1145","author":[{"given":"Krithika","family":"Bhuvaneshwar","sequence":"first","affiliation":[{"name":"Innovation Center for Biomedical Informatics, Georgetown University Medical Center; Washington, DC"}]},{"given":"Michael","family":"Harris","sequence":"additional","affiliation":[{"name":"Innovation Center for Biomedical Informatics, Georgetown University Medical Center; Washington, DC"}]},{"given":"Thanemozhi","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Innovation Center for Biomedical Informatics, Georgetown University Medical Center; Washington, DC"}]},{"given":"Laura","family":"Sheahan","sequence":"additional","affiliation":[{"name":"Innovation Center for Biomedical Informatics, Georgetown University Medical Center; Washington, DC"}]},{"given":"Difei","family":"Wang","sequence":"additional","affiliation":[{"name":"Innovation Center for Biomedical Informatics, Georgetown University Medical Center; Washington, DC"}]},{"given":"Subha","family":"Madhavan","sequence":"additional","affiliation":[{"name":"Innovation Center for Biomedical Informatics, Georgetown University Medical Center; Washington, DC"}]},{"given":"Mahlet G.","family":"Tadesse","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, Georgetown University"}]},{"given":"John","family":"Deeken","sequence":"additional","affiliation":[{"name":"Lombardi Comprehensive Cancer Center, Georgetown University, Medical Center, 3800 Reservoir Road, NW, Washington, DC 20007"}]}],"member":"320","published-online":{"date-parts":[[2013,9,22]]},"reference":[{"key":"e_1_3_2_1_1_1","volume-title":"Figg WD","author":"Sissung TM","year":"2010","unstructured":"Sissung TM , English BC , Venzon D , Figg WD , Deeken JF : Clinical pharmacology and pharmacogenetics in a genomics era: the DMET platform. Pharmacogenomics 2010 , 11(1):89--103. Sissung TM, English BC, Venzon D, Figg WD, Deeken JF: Clinical pharmacology and pharmacogenetics in a genomics era: the DMET platform. Pharmacogenomics 2010, 11(1):89--103."},{"key":"e_1_3_2_1_2_1","volume-title":"Dolginow D et al: Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study. Molecular cancer therapeutics","author":"Kahn A","year":"2007","unstructured":"Kahn A , Dolginow D et al: Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study. Molecular cancer therapeutics 2007 , 6(3):820--832. Kahn A, Dolginow D et al: Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study. Molecular cancer therapeutics 2007, 6(3):820--832."},{"key":"e_1_3_2_1_3_1","doi-asserted-by":"crossref","unstructured":"Shukla A Hillegass JM MacPherson MB Beuschel SL Vacek PM Pass HI Carbone M Testa JR Mossman BT. Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin. Mol Cancer. 2010 Dec 15; 9: 314.  Shukla A Hillegass JM MacPherson MB Beuschel SL Vacek PM Pass HI Carbone M Testa JR Mossman BT. Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin. Mol Cancer. 2010 Dec 15; 9: 314.","DOI":"10.1186\/1476-4598-9-314"},{"key":"e_1_3_2_1_4_1","first-page":"1773","volume":"2007","author":"McCubrey JA","unstructured":"McCubrey JA , Steelman LS , Chappell WH , Abrams SL , Wong EW , Chang F , Lehmann B , Terrian DM , Milella M , Tafuri A , Stivala F , Libra M , Basecke J , Evangelisti C , Martelli AM , Franklin RA. Roles of the Raf\/MEK\/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta 2007 Aug; 1773 (8):1263--84. McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Wong EW, Chang F, Lehmann B, Terrian DM, Milella M, Tafuri A, Stivala F, Libra M, Basecke J, Evangelisti C, Martelli AM, Franklin RA. Roles of the Raf\/MEK\/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta 2007 Aug; 1773 (8):1263--84.","journal-title":"Biochim Biophys Acta"},{"key":"e_1_3_2_1_5_1","first-page":"53","volume-title":"Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating","author":"Goldstein I","unstructured":"Goldstein I , Rivlin N , Shoshana OY , Ezra O , Madar S , Goldfinger N , Rotter V. Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p 53 .Carcinogenesis. 2013 Jan; 34 (1):190--8. Goldstein I, Rivlin N, Shoshana OY, Ezra O, Madar S, Goldfinger N, Rotter V. Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53.Carcinogenesis. 2013 Jan; 34 (1):190--8."},{"key":"e_1_3_2_1_6_1","first-page":"487","volume":"2012","author":"Garattini E","unstructured":"Garattini E , Terao M. The role of aldehyde oxidase in drug metabolism. Expert Opin Drug Metab Toxicol. 2012 Apr;8(4): 487 -- 503 . Garattini E, Terao M. The role of aldehyde oxidase in drug metabolism. Expert Opin Drug Metab Toxicol. 2012 Apr;8(4):487--503.","journal-title":"Expert Opin Drug Metab Toxicol."}],"event":{"name":"BCB'13: ACM-BCB2013","sponsor":["SIGBio ACM Special Interest Group on Bioinformatics"],"location":"Wshington DC USA","acronym":"BCB'13"},"container-title":["Proceedings of the International Conference on Bioinformatics, Computational Biology and Biomedical Informatics"],"original-title":[],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/2506583.2506661","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/2506583.2506661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T08:39:16Z","timestamp":1750235956000},"score":1,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/2506583.2506661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,22]]},"references-count":6,"alternative-id":["10.1145\/2506583.2506661","10.1145\/2506583"],"URL":"https:\/\/doi.org\/10.1145\/2506583.2506661","relation":{},"subject":[],"published":{"date-parts":[[2013,9,22]]},"assertion":[{"value":"2013-09-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}