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Emerg. Technol. Comput. Syst."],"published-print":{"date-parts":[[2014,12,30]]},"abstract":"<jats:p>\n            Biological systems employ compartmentalization and other co-localization strategies in order to orchestrate a multitude of biochemical processes by simultaneously enabling \u201cdata hiding\u201d and modularization. This article presents recent research that embraces compartmentalization and co-location as an organizational programmatic principle in synthetic biological and biomimetic systems. In these systems, artificial vesicles and synthetic minimal cells are envisioned as nanoscale reactors for programmable biochemical synthesis and as chassis for molecular information processing. We present P systems, brane calculi, and the recently developed\n            <jats:italic>chemtainer calculus<\/jats:italic>\n            as formal frameworks providing data hiding and modularization and thus enabling the representation of highly complicated hierarchically organized compartmentalized reaction systems. We demonstrate how compartmentalization can greatly reduce the complexity required to implement computational functionality, and how addressable compartments permit the scaling-up of programmable chemical synthesis.\n          <\/jats:p>","DOI":"10.1145\/2667231","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T13:27:09Z","timestamp":1420464429000},"page":"1-20","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Formalizing Modularization and Data Hiding in Synthetic Biology"],"prefix":"10.1145","volume":"11","author":[{"given":"Harold","family":"Fellermann","sequence":"first","affiliation":[{"name":"Newcastle University, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maik","family":"Hadorn","sequence":"additional","affiliation":[{"name":"Swiss Federal Institute of Technology, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf M.","family":"F\u00fcchslin","sequence":"additional","affiliation":[{"name":"Zurich University of Applied Sciences, Winterthur, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalio","family":"Krasnogor","sequence":"additional","affiliation":[{"name":"Newcastle University, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"320","published-online":{"date-parts":[[2014,12,30]]},"reference":[{"key":"e_1_2_1_1_1","volume-title":"Proceedings from the 2nd European Future Technologies Conference and Exhibition (FET'11)","author":"Amos M.","unstructured":"M. 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