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In this article, we present a mathematical model to evaluate system reliability in spatial (i.e., radiation-sensitive area) and temporal (i.e., performance) terms and prove that minimizing radiation-sensitive area does not necessarily maximize application reliability. To support our claim, we present an empirical counterexample where application reliability is improved even if the radiation-sensitive area of the device is increased. An extensive radiation test campaign using a 28\n            <jats:italic>nm<\/jats:italic>\n            commercial-off-the-shelf ARM-based SoC was conducted, and experimental results demonstrate that, while executing the considered application at military aircraft altitude, the probability of executing a two-year mission workload without failures is increased by 5.85% if L1 caches are enabled (thus increasing the radiation-sensitive area) when compared to no cache level being enabled. However, if both L1 and L2 caches are enabled, the probability is decreased by 31.59%.\n          <\/jats:p>","DOI":"10.1145\/2794148","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T16:34:35Z","timestamp":1452962075000},"page":"1-16","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Beyond Cross-Section"],"prefix":"10.1145","volume":"15","author":[{"given":"Thiago","family":"Santini","sequence":"first","affiliation":[{"name":"Federal University of Rio Grande do Sul"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Rech","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Luca","family":"Nazar","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1vio Rech","family":"Wagner","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"320","published-online":{"date-parts":[[2015,12,31]]},"reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1109\/ISPASS.2005.1430581"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.5555\/1131481.1131834"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.2009.2015312"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1109\/MDT.2005.69"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11265-005-6648-1"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1145\/2024716.2024718"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1145\/268806.268810"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1145\/1118299.1118507"},{"key":"e_1_2_1_9_1","unstructured":"DARPA. 2014. 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