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LBD is a knowledge discovery workflow that automatically detects significant, implicit knowledge associations hidden in fragmented knowledge areas by analysing existing scientific literature. Therefore, the LBD output not only assists in formulating scientifically sensible, novel research hypotheses but also encourages the development of cross-disciplinary research. In this systematic review, we provide an in-depth analysis of the computational techniques used in the LBD process using a novel, up-to-date, and detailed classification. Moreover, we also summarise the key milestones of the discipline through a timeline of topics. To provide a general overview of the discipline, the review outlines LBD validation checks, major LBD tools, application areas, domains, and generalisability of LBD methodologies. We also outline the insights gathered through our statistical analysis that capture the trends in LBD literature. To conclude, we discuss the prevailing research deficiencies in the discipline by highlighting the challenges and opportunities of future LBD research.<\/jats:p>","DOI":"10.1145\/3365756","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T13:21:36Z","timestamp":1575984096000},"page":"1-34","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":38,"title":["A Systematic Review on Literature-based Discovery"],"prefix":"10.1145","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4956-6171","authenticated-orcid":false,"given":"Menasha","family":"Thilakaratne","sequence":"first","affiliation":[{"name":"The University of Adelaide, Adelaide, SA, Australia"}]},{"given":"Katrina","family":"Falkner","sequence":"additional","affiliation":[{"name":"The University of Adelaide, Adelaide, SA, Australia"}]},{"given":"Thushari","family":"Atapattu","sequence":"additional","affiliation":[{"name":"The University of Adelaide, Adelaide, SA, Australia"}]}],"member":"320","published-online":{"date-parts":[[2019,12,10]]},"reference":[{"volume":"2007","volume-title":"Proceedings of the AMIA Symposium","author":"Ahlers Caroline B.","key":"e_1_2_1_1_1"},{"key":"e_1_2_1_2_1","first-page":"11","article-title":"Literature-based discovery: Critical analysis and future directions","volume":"16","author":"Ahmed Ali","year":"2016","journal-title":"Int. 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