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As most of the multimedia files are transmitted through the internet, hackers and attackers try to access the users\u2019 personal and confidential data without any authorization. Thus, maintaining a strong security technique has become a significant concerned to protect the personal information. Deoxyribonucleic Acid (DNA) computing is an advanced field for improving security, which is based on the biological concept of DNA. A novel DNA-based encryption scheme is proposed in this article for protecting multimedia files in the cloud computing environment. Here, a 1024-bit secret key is generated based on DNA computing and the user's attributes and password to encrypt any multimedia file. To generate the secret key, the decimal encoding rule, American Standard Code for Information Interchange value, DNA reference key, and complementary rule are used, which enable the system to protect the multimedia file against many security attacks. Experimental results, as well as theoretical analyses, show the efficiency of the proposed scheme over some well-known existing schemes.<\/jats:p>","DOI":"10.1145\/3392665","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T18:17:32Z","timestamp":1608229052000},"page":"1-19","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":86,"title":["Securing Multimedia by Using DNA-Based Encryption in the Cloud Computing Environment"],"prefix":"10.1145","volume":"16","author":[{"given":"Suyel","family":"Namasudra","sequence":"first","affiliation":[{"name":"National Institute of Technology Patna, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupak","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Guru Nanak Institute of Technology, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Majumder","sequence":"additional","affiliation":[{"name":"Tripura University, Suryamaninagar, Tripura, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nageswara Rao","family":"Moparthi","sequence":"additional","affiliation":[{"name":"Koneru Lakshmaiah Education Foundation, Vaddeswaram, AP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"320","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"e_1_2_1_1_1","unstructured":"A. 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