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Model. Comput. Simul."],"published-print":{"date-parts":[[2021,1,31]]},"abstract":"<jats:p>A variety of phenomena (such as the spread of diseases, pollution in rivers, etc.) can be studied as diffusion processes over networks (i.e., the diffusion of the phenomenon over a set of interconnected entities). This research introduces a method to study such diffusion processes in multiplex dynamic networks. We use a formal Modeling and Simulation methodology (in our case, DEVS, Discrete-Event System Specification). We use DEVS formal models to integrate models defined using Agent-Based Modeling and Network Theory. We present (1) an<jats:italic>Architecture<\/jats:italic>to study Diffusion Processes in Multiplex dynamic networks (ADPM) and (2) a systematic<jats:italic>Process<\/jats:italic>to define, implement, and simulate diffusion processes over such networks. We show a theoretical definition and a concrete implementation of ADPM. 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