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When monitoring daily routines for older adults, it is desirable to detect the early signs of health changes before serious health events, such as hospitalizations, happen so that timely and adequate preventive care may be provided. By deploying multi-sensor systems in homes of the elderly, we can track trajectories of daily behaviors in a feature space defined using the sensor data. In this article, we investigate a methodology for tracking the evolution of the behavior trajectories over long periods (years) using high-dimensional streaming clustering and provide very early indicators of changes in health. If we assume that habitual behaviors correspond to clusters in feature space and diseases produce a change in behavior, albeit not highly specific, tracking trajectory deviations can provide hints of early illness. Retrospectively, we visualize the streaming clustering results and track how the behavior clusters evolve in feature space with the help of two dimension-reduction algorithms: Principal Component Analysis and t-distributed Stochastic Neighbor Embedding. Moreover, our tracking algorithm in the original high-dimensional feature space generates early health warning alerts if a negative trend is detected in the behavior trajectory. We validated our algorithm on synthetic data and tested it on a pilot dataset of four TigerPlace residents monitored with a collection of motion, bed, and depth sensors over 10 years. We used the TigerPlace electronic health records to understand the residents\u2019 behavior patterns and to evaluate the health warnings generated by our algorithm. The results obtained on the TigerPlace dataset show that most of the warnings produced by our algorithm can be linked to health events documented in the electronic health records, providing strong support for a prospective deployment of the approach.<\/jats:p>","DOI":"10.1145\/3448671","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T10:09:26Z","timestamp":1626343766000},"page":"1-23","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Early Detection of Health Changes in the Elderly Using In-Home Multi-Sensor Data Streams"],"prefix":"10.1145","volume":"2","author":[{"given":"Wenlong","family":"Wu","sequence":"first","affiliation":[{"name":"University of Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Keller","sequence":"additional","affiliation":[{"name":"University of Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Skubic","sequence":"additional","affiliation":[{"name":"University of Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihail","family":"Popescu","sequence":"additional","affiliation":[{"name":"University of Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari R.","family":"Lane","sequence":"additional","affiliation":[{"name":"University of Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"320","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"e_1_2_1_1_1","volume-title":"US Population Projections","author":"Passel J. 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