{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T04:20:50Z","timestamp":1750220450297,"version":"3.41.0"},"publisher-location":"New York, NY, USA","reference-count":38,"publisher":"ACM","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.acm.org\/publications\/policies\/copyright_policy#Background"}],"content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1,22]]},"DOI":"10.1145\/3448748.3448757","type":"proceedings-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T02:07:15Z","timestamp":1616378835000},"page":"49-55","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome analysis and identification of key pathway in visceral adipose tissue from obesity-related diabetes"],"prefix":"10.1145","author":[{"given":"Yue","family":"Shi","sequence":"first","affiliation":[{"name":"Medical School of Nantong University, Nantong, China."}]},{"given":"Wentao","family":"Han","sequence":"additional","affiliation":[{"name":"Medical School of Nantong University, Nantong, China."}]},{"given":"Huagen","family":"Wei","sequence":"additional","affiliation":[{"name":"Medical School of Nantong University, Nantong, China."}]},{"given":"Siwei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Medical School of Nantong University, Nantong, China."}]},{"given":"Weizheng","family":"Kong","sequence":"additional","affiliation":[{"name":"Medical School of Nantong University, Nantong, China."}]},{"given":"Lili","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Medical School of Nantong University, Nantong, China."}]},{"given":"Huiqun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Medical School of Nantong University, Nantong, China."}]}],"member":"320","published-online":{"date-parts":[[2021,3,21]]},"reference":[{"key":"e_1_3_2_1_1_1","volume-title":"Incidence Trends of Type 1 and Type 2 Diabetes among Youths","author":"Mayer-Davis EJ.","year":"2002","unstructured":"EJ. Mayer-Davis, D. Dabelea, JM. Lawrence, et al. Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002-2012. N Engl J Med. 2017 Apr 13; 376(15): 1419--1429."},{"key":"e_1_3_2_1_2_1","volume-title":"The contribution of family history to the burden of diagnosed diabetes, undiagnosed diabetes, and prediabetes in the United States: analysis of the National Health and Nutrition Examination Survey","author":"Moonesinghe R.","year":"2009","unstructured":"R. Moonesinghe, GLA. Beckles, T. Liu, MJ. Khoury. The contribution of family history to the burden of diagnosed diabetes, undiagnosed diabetes, and prediabetes in the United States: analysis of the National Health and Nutrition Examination Survey, 2009-2014. Genet Med. 2018; 20(10): 1159--1166."},{"key":"e_1_3_2_1_3_1","doi-asserted-by":"crossref","unstructured":"F. Daneshgari G. Liu AT. Hanna-Mitchell. Path of the translational discovery of urological complications of obesity and diabetes. Am J Physiol Renal Physiol. 2017;312(5): F887-F896.","DOI":"10.1152\/ajprenal.00489.2016"},{"key":"e_1_3_2_1_4_1","doi-asserted-by":"crossref","unstructured":"MH. Tan R. Men Iyengar K. Mizokami-Stout et al. Spectrum of immune checkpoint inhibitors-induced endocrinopathies in cancer patients: a scoping review of case reports. Clin diabetes endocrinol. 2019; 5: 1.","DOI":"10.1186\/s40842-018-0073-4"},{"key":"e_1_3_2_1_5_1","doi-asserted-by":"crossref","unstructured":"Y. Yang L. Chan. Monogenic Diabetes: What it teaches us on the common forms of type 1 and type 2 diabetes. Endocr Rev. 2016;37(3): 190--222.","DOI":"10.1210\/er.2015-1116"},{"key":"e_1_3_2_1_6_1","doi-asserted-by":"crossref","unstructured":"A. Boles R. Kandimalla PH. Reddy. Dynamics of diabetes and obesity: epidemiological perspective. Biochim Biophys Acta. 2017;1863(5): 1026--1036.","DOI":"10.1016\/j.bbadis.2017.01.016"},{"key":"e_1_3_2_1_7_1","volume-title":"Trends in diabetes and obesity in Samoa over 35 years","author":"Lin S.","year":"1978","unstructured":"S. Lin, T. Naseri, C. Linhart, S. Morrell, R. Taylor, ST. McGarvey, DJ. Magliano, P. Zimmet. Trends in diabetes and obesity in Samoa over 35 years, 1978-2013. Diabet Med. 2017;34(5): 654--661."},{"key":"e_1_3_2_1_8_1","volume-title":"Trends of obesity prevalence among Spanish adults with diabetes","author":"Basterra-Gortari FJ.","year":"1987","unstructured":"FJ. Basterra-Gortari, M. Bes-Rastrollo, M. Ruiz-Canela, A. Gea, C. Say\u00f3n-Orea, M\u00c1. Mart\u00ednez-Gonz\u00e1lez. Trends of obesity prevalence among Spanish adults with diabetes, 1987-2012. Med Clin (Barc). 2019;152(5): 181--184."},{"key":"e_1_3_2_1_9_1","doi-asserted-by":"crossref","unstructured":"A. Sonmez V. Yumuk C. Haymana I. Demirci C. Barcin S. K\u0131y\u0131c\u0131 S. G\u00fcldiken G. \u00d6r\u00fck B. Ozgen Saydam S. Baldane F. Kutlut\u00fcrk FK. K\u00fc\u00e7\u00fckler O. Deyneli B. \u00c7etinarslan T. Sabuncu F. Bayram I. Satman. TEMD Study Group. Impact of obesity on the metabolic control of type 2 diabetes: results of the Turkish nationwide survey of glycemic and other metabolic parameters of patients with diabetes mellitus (TEMD Obesity Study). Obes Facts. 2019;12(2): 167--178.","DOI":"10.1159\/000496624"},{"key":"e_1_3_2_1_10_1","doi-asserted-by":"crossref","unstructured":"G. Goswami N. Shinkazh N. Davis. Optimal Pharmacologic treatment strategies in obesity and type 2 diabetes. J Clin Med. 2014;3(2): 595--613","DOI":"10.3390\/jcm3020595"},{"key":"e_1_3_2_1_11_1","doi-asserted-by":"crossref","unstructured":"MF. Horlyck-Romanovsky K. Wyka SE. Echeverria MM. Leung M. Fuster TT. Huang. Foreign-born blacks experience lower odds of obesity but higher odds of diabetes than US-born blacks in New York city. J Immigr Minor Health.2019;21(1): 47--55.","DOI":"10.1007\/s10903-018-0708-7"},{"key":"e_1_3_2_1_12_1","doi-asserted-by":"crossref","unstructured":"M. Asamoah-Boaheng EY. Tenkorang O. Sarfo-Kantanka. Time to the onset of type 2 diabetes mellitus in Ghana. Int Health.2019;11(2): 101--107.","DOI":"10.1093\/inthealth\/ihy057"},{"key":"e_1_3_2_1_13_1","doi-asserted-by":"crossref","unstructured":"PW. Franks KA. Jablonski LM. Delahanty et al. Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the diabetes prevention program. Diabetologia. 2008;51(12): 2214--2223.","DOI":"10.1007\/s00125-008-1158-x"},{"key":"e_1_3_2_1_14_1","doi-asserted-by":"crossref","unstructured":"Y. Cao T. Wang Y. Wu J. Juan X. Qin X. Tang T. Wu Y. Hu. Opposite genetic effects of CMIP polymorphisms on the risk of type 2 diabetes and obesity: a family-based study in China. Int J Mol Sci. 2018;19(4): 1011.","DOI":"10.3390\/ijms19041011"},{"key":"e_1_3_2_1_15_1","volume-title":"T cell-derived IL-22 amplifies IL- 1\u03b2-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes. Diabetes. 2014","author":"Dalmas E.","year":"1966","unstructured":"E. Dalmas, N. Venteclef, C. Caer, C. Poitou, I. Cremer, J. Aron-Wisnewsky, S. Lacroix-Desmazes, J. Bayry, SV. Kaveri, K. Cl\u00e9ment, S. Andr\u00e9, M. Guerre-Millo. T cell-derived IL-22 amplifies IL- 1\u03b2-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes. Diabetes. 2014; 63(6): 1966--77."},{"key":"e_1_3_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw937"},{"key":"e_1_3_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_3_2_1_18_1","doi-asserted-by":"crossref","unstructured":"SE. Kahn RL. Hull KM. Utzschneider. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444(7121): 840--846.","DOI":"10.1038\/nature05482"},{"key":"e_1_3_2_1_19_1","doi-asserted-by":"crossref","unstructured":"T. Masuyama Y. Katsuda M. Shinohara. A novel model of obesity-related diabetes: introgression of the Lepr(fa) allele of the Zucker fatty rat into nonobese Spontaneously Diabetic Torii (SDT) rats. Exp Anim. 2005;54(1): 13--20.","DOI":"10.1538\/expanim.54.13"},{"key":"e_1_3_2_1_20_1","doi-asserted-by":"crossref","unstructured":"X. Wen C. Qian Y. Zhang R. Wu L. Lu C. Zhu X. Cheng R. Cui H. You F. Mei J. Gao F. Li L. Bu S. Qu. Key pathway and gene alterations in the gastric mucosa associated with obesity and obesity-related diabetes. J Cell Biochem. 2019;120(4): 6763--6771.","DOI":"10.1002\/jcb.27976"},{"key":"e_1_3_2_1_21_1","doi-asserted-by":"crossref","unstructured":"N. Liadis K. Murakami M. Eweida AR. Elford L. Sheu HY. Gaisano R. Hakem PS. Ohashi M. Woo. Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus. Mol Cell Biol.2005;25(9): 3620--9.","DOI":"10.1128\/MCB.25.9.3620-3629.2005"},{"key":"e_1_3_2_1_22_1","doi-asserted-by":"crossref","unstructured":"FJ. Tinahones L. Co\u00edn Arag\u00fcez M. Murri W. Oliva Olivera MD. Mayas Torres N. Barbarroja R. Gomez Huelgas MM. Malag\u00f3n R. El Bekay. Caspase induction and BCL2 inhibition in human adipose tissue: a potential relationship with insulin signaling alteration. Diabetes Care.2013;36(3): 513--21.","DOI":"10.2337\/dc12-0194"},{"key":"e_1_3_2_1_23_1","doi-asserted-by":"crossref","unstructured":"A. Radziszewska A. Stephanie. Schroer Diana Choi Panteha Tajmir Nikolina Radulovich James C. Ho Linyuan Wang Nicole Liadis Razqallah Hakem Ming-Sound Tsao Linda Z. Penn Gerard I. Evan and Minna Woo. Absence of Caspase-3 protects pancreatic \u03b2-Cells from c-Myc-induced apoptosis without leading to tumor formation. J Biol Chem. 2009;284(16): 10947- 10956.","DOI":"10.1074\/jbc.M806960200"},{"key":"e_1_3_2_1_24_1","doi-asserted-by":"crossref","unstructured":"F. Tarquini R. Tiribuzi L. Crispoltoni S. Porcellati AM. Del Pino A. Orlacchio G. Coata S. Arnone E. Torlone B. Cappuccini GC. Di Renzo A. Orlacchio. Caspase 3 activation and PARP cleavage in lymphocytes from newborn babies of diabetic mothers with unbalanced glycaemic control. Cell Biochem Funct.2014;32(1): 87--95.","DOI":"10.1002\/cbf.2975"},{"key":"e_1_3_2_1_25_1","doi-asserted-by":"crossref","unstructured":"JC. Gutierrez MR. Prater BJ. Smith LE. Freeman MK. Mallela SD. Holladay. Late-gestation ventricular myocardial reduction in fetuses of hyperglycemic CD1 mice is associated with increased apoptosis. Birth Defects Res B Dev Reprod Toxicol.2009;86(5):409- 15.","DOI":"10.1002\/bdrb.20212"},{"key":"e_1_3_2_1_26_1","doi-asserted-by":"crossref","unstructured":"A. Camargo OA. Rangel-Z\u00fa\u00f1iga J. Alcal\u00e1-D\u00edaz F. Gomez-Delgado J. Delgado-Lista S. Garc\u00eda-Carpintero C. Mar\u00edn Y. Almad\u00e9n EM. Yubero-Serrano J. L\u00f3pez-Moreno FJ. Tinahones P. P\u00e9rez-Mart\u00ednez HM. Roche J. L\u00f3pez-Miranda. Dietary fat may modulate adipose tissue homeostasis through the processes of autophagy and apoptosis. Eur J Nutr.2017;56(4): 1621- 1628.","DOI":"10.1007\/s00394-016-1208-y"},{"key":"e_1_3_2_1_27_1","unstructured":"L. You W. Gu L. Chen L. Pan J. Chen Y. Peng. MiR-378 overexpression attenuates high glucose-suppressed osteogenic differentiation through targeting CASP3 and activating PI3K\/Akt signaling pathway. Int J Clin Exp Pathol. 2014;7(10): 7249--61."},{"volume-title":"78th Congress of the European-Atherosclerosis-Society Atherosclerosis supplements.2010; 11(2): 8--8.","author":"Menghini R.","key":"e_1_3_2_1_28_1","unstructured":"R. Menghini, V. Casagrande, M. Cavalera, V. Marzano, S. Menini, G. Pugliese, A. Urbani, R. Lauro, M. Federici. TIMP3: A switch that controls high fat diet-induced inflammation, diabetes and steatosis in mice. 78th Congress of the European-Atherosclerosis-Society Atherosclerosis supplements.2010; 11(2): 8--8."},{"key":"e_1_3_2_1_29_1","doi-asserted-by":"crossref","unstructured":"R. Menghini V. Casagrande S. Menini A. Marino V. Marzano ML. Hribal P. Gentileschi D. Lauro O. Schillaci G. Pugliese P. Sbraccia A. Urbani R. Lauro M. Federici. TIMP3 overexpression in macrophages protects from insulin resistance adipose inflammation and nonalcoholic fatty liver disease in mice. Diabetes.2012;61(2): 454--62.","DOI":"10.2337\/db11-0613"},{"key":"e_1_3_2_1_30_1","doi-asserted-by":"crossref","unstructured":"M. Cardellini R. Menghini E. Martelli V. Casagrande A. Marino S. Rizza O. Porzio A. Mauriello A. Solini A. Ippoliti R. Lauro F. Folli M. Federici. TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1. Diabetes. 2009;58(10): 2396--401.","DOI":"10.2337\/db09-0280"},{"key":"e_1_3_2_1_31_1","doi-asserted-by":"crossref","unstructured":"M. Federici ML. Hribal R. Menghini H. Kanno V. Marchetti O. Porzio SW. Sunnarborg S. Rizza M. Serino V. Cunsolo D. Lauro A. Mauriello DS. Smookler P. Sbraccia G. Sesti DC. Lee R. Khokha D. Accii R. Lauro. Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha. J Clin Invest. 2005;115(12): 3494--505.","DOI":"10.1172\/JCI26052"},{"key":"e_1_3_2_1_32_1","doi-asserted-by":"crossref","unstructured":"FF. Mohammed DS. Smookler SE. Taylor B. Fingleton Z. Kassiri OH. Sanchez JL. English LM. Matrisian B. Au WC. Yeh R. Khokha. Abnormal TNF activity in Timp3-\/- mice leads to chronic hepatic inflammation and failure of liver regeneration. Nat Genet. 2004;36(9): 969--77.","DOI":"10.1038\/ng1413"},{"key":"e_1_3_2_1_33_1","doi-asserted-by":"crossref","unstructured":"R. St\u00f6hr M. Cavalera S. Menini M. Mavilio V. Casagrande C. Rossi A. Urbani M. Cardellini G. Pugliese R. Menghini M. Federici. Loss of TIMP3 exacerbates atherosclerosis in ApoE null mice. Atherosclerosis. 2014;235(2): 438--43.","DOI":"10.1016\/j.atherosclerosis.2014.05.946"},{"key":"e_1_3_2_1_34_1","doi-asserted-by":"crossref","unstructured":"V. Casagrande R. Menghini S. Menini A. Marino V. Marchetti M. Cavalera M. Fabrizi ML. Hribal G. Pugliese P. Gentileschi O. Schillaci O. Porzio D. Lauro P. Sbraccia R. Lauro M. Federici. Overexpression of tissue inhibitor of metalloproteinase 3 in macrophages reduces atherosclerosis in low-density lipoprotein (LDL) receptor knockout mice. Arterioscler Thromb Vasc Biol.2012;32(1): 74--81.","DOI":"10.1161\/ATVBAHA.111.238402"},{"volume-title":"Effect of tissue inhibitor of metalloproteinases three on DLK1 shedding in cultured human pre-adipocytes and implications for adipose tissue remodeling. Lancet. 2015;385 Suppl 1: S35","author":"Fenech M.","key":"e_1_3_2_1_35_1","unstructured":"M. Fenech, J. Gavrilovic, J. Turner. Effect of tissue inhibitor of metalloproteinases three on DLK1 shedding in cultured human pre-adipocytes and implications for adipose tissue remodeling. Lancet. 2015;385 Suppl 1: S35."},{"key":"e_1_3_2_1_36_1","doi-asserted-by":"crossref","unstructured":"C. Rossi V. Marzano A. Consalvo M. Zucchelli S. Levi Mortera V. Casagrande M. Mavilio P. Sacchetta M. Federici R. Menghini A. Urbani D. Ciavardelli. Proteomic and metabolomic characterization of streptozotocin-induced diabetic nephropathy in TIMP3-deficient mice. Acta Diabetol. 2018;55(2):121- 129.","DOI":"10.1007\/s00592-017-1074-y"},{"key":"e_1_3_2_1_37_1","doi-asserted-by":"crossref","unstructured":"J. Wang J. Zhang X. Chen Y. Yang F. Wang W. Li M. Awuti Y. Sun C. Lian Z. Li M. Wang JY. Xu C. Jin H. Tian F. Gao J. Zhang D. Sinha L. Lu GT. Xu. MiR-365 promotes diabetic retinopathy through inhibiting Timp3 and increasing oxidative stress. Exp Eye Res. 2018; 168: 89--99.","DOI":"10.1016\/j.exer.2017.11.006"},{"key":"e_1_3_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.05.946"}],"event":{"name":"BIC 2021: 2021 International Conference on Bioinformatics and Intelligent Computing","sponsor":["University of Arizona University of Arizona"],"location":"Harbin China","acronym":"BIC 2021"},"container-title":["Proceedings of the 2021 International Conference on Bioinformatics and Intelligent Computing"],"original-title":[],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3448748.3448757","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3448748.3448757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T20:47:52Z","timestamp":1750193272000},"score":1,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3448748.3448757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,22]]},"references-count":38,"alternative-id":["10.1145\/3448748.3448757","10.1145\/3448748"],"URL":"https:\/\/doi.org\/10.1145\/3448748.3448757","relation":{},"subject":[],"published":{"date-parts":[[2021,1,22]]},"assertion":[{"value":"2021-03-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}