{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T22:54:32Z","timestamp":1753052072723,"version":"3.41.0"},"publisher-location":"New York, NY, USA","reference-count":27,"publisher":"ACM","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.acm.org\/publications\/policies\/copyright_policy#Background"}],"content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10,26]]},"DOI":"10.1145\/3459637.3481938","type":"proceedings-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T15:53:43Z","timestamp":1636991623000},"page":"3727-3736","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Multi-Property Molecular Optimization using an Integrated Poly-Cycle Architecture"],"prefix":"10.1145","author":[{"given":"Guy","family":"Barshatski","sequence":"first","affiliation":[{"name":"Technion - Israel Institute of Technology, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galia","family":"Nordon","sequence":"additional","affiliation":[{"name":"Technion - Israel Institute of Technology, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kira","family":"Radinsky","sequence":"additional","affiliation":[{"name":"Technion - Israel Institute of Technology, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"320","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"key":"e_1_3_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1145\/3447548.3467120"},{"volume-title":"Quantifying the chemical beauty of drugs. Nature chemistry","year":"2012","author":"Bickerton Richard","key":"e_1_3_2_2_2_1"},{"key":"e_1_3_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.3115\/v1\/D14-1179"},{"volume-title":"Syntax-Directed Variational Autoencoder for Structured Data. In International Conference on Learning Representations.","year":"2018","author":"Dai Hanjun","key":"e_1_3_2_2_4_1"},{"volume-title":"CORE: Automatic Molecule Optimization Using Copy & Refine Strategy. In 34th AAAI Conference on Artificial Intelligence (AAAI-20)","year":"2020","author":"Fu Tianfan","key":"e_1_3_2_2_5_1"},{"key":"e_1_3_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.7b00572"},{"key":"e_1_3_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1145\/3219819.3219882"},{"volume-title":"Junction Tree Variational Autoencoder for Molecular Graph Generation. In International Conference on Machine Learning. 2323--2332","year":"2018","author":"Jin Wengong","key":"e_1_3_2_2_8_1"},{"key":"e_1_3_2_2_9_1","unstructured":"Wengong Jin Regina Barzilay and Tommi Jaakkola. 2019 a. Hierarchical graph-to-graph translation for molecules. (2019).  Wengong Jin Regina Barzilay and Tommi Jaakkola. 2019 a. Hierarchical graph-to-graph translation for molecules. (2019)."},{"volume-title":"International Conference on Machine Learning. PMLR, 4849--4859","year":"2020","author":"Jin Wengong","key":"e_1_3_2_2_10_1"},{"volume-title":"Learning Multimodal Graph-to-Graph Translation for Molecule Optimization. In International Conference on Learning Representations.","year":"2019","author":"Jin Wengong","key":"e_1_3_2_2_11_1"},{"key":"e_1_3_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-46475-6_43"},{"volume-title":"Adam: A Method for Stochastic Optimization. In 3rd International Conference on Learning Representations, ICLR 2015, San Diego, CA, USA, May 7-9, 2015, Conference Track Proceedings.","author":"Diederik","key":"e_1_3_2_2_13_1"},{"volume-title":"Kingma and Max Welling","year":"2014","author":"Diederik","key":"e_1_3_2_2_14_1"},{"key":"e_1_3_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.5555\/3305381.3305582"},{"volume-title":"Rdkit: Open-source cheminformatics software.","year":"2016","author":"Landrum G","key":"e_1_3_2_2_16_1"},{"volume-title":"Decoupled Weight Decay Regularization. In International Conference on Learning Representations.","year":"2019","author":"Loshchilov Ilya","key":"e_1_3_2_2_17_1"},{"key":"e_1_3_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-019-0404-1"},{"key":"e_1_3_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-017-0235-x"},{"key":"e_1_3_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.5555\/3454287.3455008"},{"volume-title":"Deep Reinforcement Learning for De-Novo Drug Design. CoRR","year":"2017","author":"Popova Mariya","key":"e_1_3_2_2_21_1"},{"key":"e_1_3_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci100050t"},{"key":"e_1_3_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0017-4"},{"key":"e_1_3_2_2_24_1","doi-asserted-by":"crossref","unstructured":"Martin Simonovsky and N. Komodakis. 2018. GraphVAE: Towards Generation of Small Graphs Using Variational Autoencoders. In ICANN.  Martin Simonovsky and N. Komodakis. 2018. GraphVAE: Towards Generation of Small Graphs Using Variational Autoencoders. In ICANN.","DOI":"10.1007\/978-3-030-01418-6_41"},{"key":"e_1_3_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci00057a005"},{"key":"e_1_3_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1162\/neco.1989.1.2.270"},{"volume-title":"Unpaired Image-to-Image Translation Using Cycle-Consistent Adversarial Networks. In 2017 IEEE International Conference on Computer Vision (ICCV). 2242--2251","author":"Zhu J.","key":"e_1_3_2_2_27_1"}],"event":{"name":"CIKM '21: The 30th ACM International Conference on Information and Knowledge Management","sponsor":["SIGWEB ACM Special Interest Group on Hypertext, Hypermedia, and Web","SIGIR ACM Special Interest Group on Information Retrieval"],"location":"Virtual Event Queensland Australia","acronym":"CIKM '21"},"container-title":["Proceedings of the 30th ACM International Conference on Information &amp; Knowledge Management"],"original-title":[],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3459637.3481938","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3459637.3481938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T20:48:58Z","timestamp":1750193338000},"score":1,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3459637.3481938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,26]]},"references-count":27,"alternative-id":["10.1145\/3459637.3481938","10.1145\/3459637"],"URL":"https:\/\/doi.org\/10.1145\/3459637.3481938","relation":{},"subject":[],"published":{"date-parts":[[2021,10,26]]},"assertion":[{"value":"2021-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}