{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T04:21:24Z","timestamp":1750220484759,"version":"3.41.0"},"publisher-location":"New York, NY, USA","reference-count":38,"publisher":"ACM","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.acm.org\/publications\/policies\/copyright_policy#Background"}],"funder":[{"name":"European Union","award":["839553"],"award-info":[{"award-number":["839553"]}]},{"name":"European Union's Horizon 2020 Research","award":["824164"],"award-info":[{"award-number":["824164"]}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["314647, 326452"],"award-info":[{"award-number":["314647, 326452"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union 2","award":["713645"],"award-info":[{"award-number":["713645"]}]}],"content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9,7]]},"DOI":"10.1145\/3477206.3477460","type":"proceedings-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T10:19:34Z","timestamp":1631873974000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Astrocytes in modulating subcellular, cellular and intercellular molecular neuronal communication"],"prefix":"10.1145","author":[{"given":"Jari","family":"Hyttinen","sequence":"first","affiliation":[{"name":"Tampere University, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Genocchi","sequence":"additional","affiliation":[{"name":"Tampere University, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Ahtiainen","sequence":"additional","affiliation":[{"name":"Tampere University, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarno M.A.","family":"Tanskanen","sequence":"additional","affiliation":[{"name":"Tampere University, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Lenk","sequence":"additional","affiliation":[{"name":"Institute of Neural Engineering, Graz, University of Technology, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Taynnan","family":"Barros","sequence":"additional","affiliation":[{"name":"School of Computer Science and Electronic Engineering, University of Essex, Colchester, UK and Tampere University, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"320","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"e_1_3_2_1_1_1","volume-title":"Tripartite synapses: glia, the unacknowledged partner. Trends in neurosciences 22, 5","author":"Araque Alfonso","year":"1999","unstructured":"Alfonso Araque , Vladimir Parpura , Rita P Sanzgiri , and Philip G Haydon . 1999. Tripartite synapses: glia, the unacknowledged partner. Trends in neurosciences 22, 5 ( 1999 ), 208--215. Alfonso Araque, Vladimir Parpura, Rita P Sanzgiri, and Philip G Haydon. 1999. Tripartite synapses: glia, the unacknowledged partner. Trends in neurosciences 22, 5 (1999), 208--215."},{"key":"e_1_3_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1109\/TCOMM.2015.2487349"},{"key":"e_1_3_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1109\/TCBB.2018.2887222"},{"key":"e_1_3_2_1_4_1","volume-title":"Engineering calcium signaling of astrocytes for neural-molecular computing logic gates. Scientific reports 11, 1","author":"Barros Michael Taynnan","year":"2021","unstructured":"Michael Taynnan Barros , Phuong Doan , Meenakshisundaram Kandhavelu , Brendan Jennings , and Sasitharan Balasubramaniam . 2021. Engineering calcium signaling of astrocytes for neural-molecular computing logic gates. Scientific reports 11, 1 ( 2021 ), 1--10. Michael Taynnan Barros, Phuong Doan, Meenakshisundaram Kandhavelu, Brendan Jennings, and Sasitharan Balasubramaniam. 2021. Engineering calcium signaling of astrocytes for neural-molecular computing logic gates. Scientific reports 11, 1 (2021), 1--10."},{"key":"e_1_3_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2018.2885518"},{"key":"e_1_3_2_1_6_1","volume-title":"Science 356, 6339","author":"Bindocci Erika","year":"2017","unstructured":"Erika Bindocci , Iaroslav Savtchouk , Nicolas Liaudet , Denise Becker , Giovanni Carriero , and Andrea Volterra . 2017. Three-dimensional Ca2+ imaging advances understanding of astrocyte biology. Science 356, 6339 ( 2017 ). Erika Bindocci, Iaroslav Savtchouk, Nicolas Liaudet, Denise Becker, Giovanni Carriero, and Andrea Volterra. 2017. Three-dimensional Ca2+ imaging advances understanding of astrocyte biology. Science 356, 6339 (2017)."},{"key":"e_1_3_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3484"},{"key":"e_1_3_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32237"},{"key":"e_1_3_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2018.00094"},{"key":"e_1_3_2_1_10_1","volume-title":"Simulation of calcium signaling in fine astrocytic processes: Effect of spatial properties on spontaneous activity. PLoS computational biology 15, 8","author":"Denizot Audrey","year":"2019","unstructured":"Audrey Denizot , Misa Arizono , U Valentin N\u00e4gerl , H\u00e9di Soula , and Hugues Berry . 2019. Simulation of calcium signaling in fine astrocytic processes: Effect of spatial properties on spontaneous activity. PLoS computational biology 15, 8 ( 2019 ), e1006795. Audrey Denizot, Misa Arizono, U Valentin N\u00e4gerl, H\u00e9di Soula, and Hugues Berry. 2019. Simulation of calcium signaling in fine astrocytic processes: Effect of spatial properties on spontaneous activity. PLoS computational biology 15, 8 (2019), e1006795."},{"key":"e_1_3_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0016-17.2017"},{"key":"e_1_3_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13243-0"},{"key":"e_1_3_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00294"},{"key":"e_1_3_2_1_14_1","volume-title":"Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior. Annual review of physiology 72","author":"Haydon Halassa","year":"2010","unstructured":"MichaelM Halassa and Philip G Haydon . 2010. Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior. Annual review of physiology 72 ( 2010 ), 335--355. MichaelMHalassa and Philip G Haydon. 2010. Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior. Annual review of physiology 72 (2010), 335--355."},{"key":"e_1_3_2_1_15_1","volume-title":"Magistretti","author":"Jolivet Renaud","year":"2015","unstructured":"Renaud Jolivet , Jay S. Coggan , Igor Allaman , and Pierre J . Magistretti . 2015 . Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble. PLOS Computational Biology 11 (02 2015). Renaud Jolivet, Jay S. Coggan, Igor Allaman, and Pierre J. Magistretti. 2015. Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble. PLOS Computational Biology 11 (02 2015)."},{"key":"e_1_3_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3206698"},{"key":"e_1_3_2_1_17_1","volume-title":"Temporally coordinated spiking activity of human induced pluripotent stem cell-derived neurons co-cultured with astrocytes. Biochemical and biophysical research communications 495, 1","author":"Kayama Tasuku","year":"2018","unstructured":"Tasuku Kayama , Ikuro Suzuki , Aoi Odawara , Takuya Sasaki , and Yuji Ikegaya . 2018. Temporally coordinated spiking activity of human induced pluripotent stem cell-derived neurons co-cultured with astrocytes. Biochemical and biophysical research communications 495, 1 ( 2018 ), 1028--1033. Tasuku Kayama, Ikuro Suzuki, Aoi Odawara, Takuya Sasaki, and Yuji Ikegaya. 2018. Temporally coordinated spiking activity of human induced pluripotent stem cell-derived neurons co-cultured with astrocytes. Biochemical and biophysical research communications 495, 1 (2018), 1028--1033."},{"key":"e_1_3_2_1_18_1","volume-title":"EMBEC & NBC","author":"Khalid Muhammad Uzair","year":"2017","unstructured":"Muhammad Uzair Khalid , Aapo Tervonen , Iina Korkka , Jari Hyttinen , and Kerstin Lenk . 2017. Geometry-based computational modeling of calcium signaling in an astrocyte . In EMBEC & NBC 2017 . Springer , 157--160. Muhammad Uzair Khalid, Aapo Tervonen, Iina Korkka, Jari Hyttinen, and Kerstin Lenk. 2017. Geometry-based computational modeling of calcium signaling in an astrocyte. In EMBEC & NBC 2017. Springer, 157--160."},{"key":"e_1_3_2_1_19_1","volume-title":"Eshel Ben-Jacob, and Hugues Berry.","author":"Lallouette Jules","year":"2014","unstructured":"Jules Lallouette , Maurizio De Pitt\u00e0 , Eshel Ben-Jacob, and Hugues Berry. 2014 . Sparse short-distance connections enhance calcium wave propagation in a 3D model of astrocyte networks. Frontiers in computational neuroscience 8 (2014), 45. Jules Lallouette, Maurizio De Pitt\u00e0, Eshel Ben-Jacob, and Hugues Berry. 2014. Sparse short-distance connections enhance calcium wave propagation in a 3D model of astrocyte networks. Frontiers in computational neuroscience 8 (2014), 45."},{"key":"e_1_3_2_1_20_1","volume-title":"GABA release by hippocampal astrocytes. Frontiers in computational neuroscience 6","author":"Meur Karim Le","year":"2012","unstructured":"Karim Le Meur , Juan Mendizabal-Zubiaga , Pedro Grandes , and Etienne Audinat . 2012. GABA release by hippocampal astrocytes. Frontiers in computational neuroscience 6 ( 2012 ), 59. Karim Le Meur, Juan Mendizabal-Zubiaga, Pedro Grandes, and Etienne Audinat. 2012. GABA release by hippocampal astrocytes. Frontiers in computational neuroscience 6 (2012), 59."},{"key":"e_1_3_2_1_21_1","volume-title":"Larger Connection Radius Increases Hub Astrocyte Number in a 3D Neuron- Astrocyte Network Model","author":"Lenk Kerstin","year":"2021","unstructured":"Kerstin Lenk , Barbara Genocchi , Michael T Barros , and Jari AK Hyttinen . 2021. Larger Connection Radius Increases Hub Astrocyte Number in a 3D Neuron- Astrocyte Network Model . IEEE Transactions on Molecular, Biological and Multi- Scale Communications ( 2021 ). Kerstin Lenk, Barbara Genocchi, Michael T Barros, and Jari AK Hyttinen. 2021. Larger Connection Radius Increases Hub Astrocyte Number in a 3D Neuron- Astrocyte Network Model. IEEE Transactions on Molecular, Biological and Multi- Scale Communications (2021)."},{"key":"e_1_3_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2019.00092"},{"key":"e_1_3_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2018.00020"},{"key":"e_1_3_2_1_24_1","doi-asserted-by":"crossref","unstructured":"Ben M Maoz Anna Herland Edward A FitzGerald Thomas Grevesse Charles Vidoudez Alan R Pacheco Sean P Sheehy Tae-Eun Park Stephanie Dauth Robert Mannix etal 2018. A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells. Nature biotechnology 36 9 (2018) 865--874.  Ben M Maoz Anna Herland Edward A FitzGerald Thomas Grevesse Charles Vidoudez Alan R Pacheco Sean P Sheehy Tae-Eun Park Stephanie Dauth Robert Mannix et al. 2018. A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells. Nature biotechnology 36 9 (2018) 865--874.","DOI":"10.1038\/nbt.4226"},{"key":"e_1_3_2_1_25_1","volume-title":"The computational power of astrocyte mediated synaptic plasticity. Frontiers in computational neuroscience 6","author":"Min Rogier","year":"2012","unstructured":"Rogier Min , Mirko Santello , and Thomas Nevian . 2012. The computational power of astrocyte mediated synaptic plasticity. Frontiers in computational neuroscience 6 ( 2012 ), 93. Rogier Min, Mirko Santello, and Thomas Nevian. 2012. The computational power of astrocyte mediated synaptic plasticity. Frontiers in computational neuroscience 6 (2012), 93."},{"key":"e_1_3_2_1_26_1","unstructured":"Madhu S. Nair. [n.d.]. Histogram Equalization and Local Histogram Equalization of Images. Available: https:\/\/www.mathworks.com\/matlabcentral\/fileexchange\/ 13729-histogram-equalization-and-local-histogram-equalization.  Madhu S. Nair. [n.d.]. Histogram Equalization and Local Histogram Equalization of Images. Available: https:\/\/www.mathworks.com\/matlabcentral\/fileexchange\/ 13729-histogram-equalization-and-local-histogram-equalization."},{"key":"e_1_3_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2003.08.008"},{"key":"e_1_3_2_1_28_1","volume-title":"Alzheimer's disease-related amyloid-.. induces synaptotoxicity in human iPS cell-derived neurons. Cell death & disease 6, 4","author":"Nieweg K","year":"2015","unstructured":"K Nieweg , A Andreyeva , B Van Stegen , G Tanriover , and K Gottmann . 2015. Alzheimer's disease-related amyloid-.. induces synaptotoxicity in human iPS cell-derived neurons. Cell death & disease 6, 4 ( 2015 ), e1709--e1709. K Nieweg, A Andreyeva, B Van Stegen, G Tanriover, and K Gottmann. 2015. Alzheimer's disease-related amyloid-.. induces synaptotoxicity in human iPS cell-derived neurons. Cell death & disease 6, 4 (2015), e1709--e1709."},{"key":"e_1_3_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4707-08.2009"},{"key":"e_1_3_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2017.01.027"},{"key":"e_1_3_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0154"},{"key":"e_1_3_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019109"},{"key":"e_1_3_2_1_33_1","volume-title":"Rusakov","author":"Savtchenko Leonid P.","year":"2018","unstructured":"Leonid P. Savtchenko , Lucie Bard , Thomas P. Jensen , James P. Reynolds , Igor Kraev , Nikolay Medvedev , Michael G. Stewart , Christian Henneberger , and Dmitri A . Rusakov . 2018 . Disentangling astroglial physiology with a realistic cell model in silico. Nature Communications 9, 1 (2018). Leonid P. Savtchenko, Lucie Bard, Thomas P. Jensen, James P. Reynolds, Igor Kraev, Nikolay Medvedev, Michael G. Stewart, Christian Henneberger, and Dmitri A. Rusakov. 2018. Disentangling astroglial physiology with a realistic cell model in silico. Nature Communications 9, 1 (2018)."},{"key":"e_1_3_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0017-17.2017"},{"key":"e_1_3_2_1_35_1","volume-title":"Nature neuroscience 18, 5","author":"Srinivasan Rahul","year":"2015","unstructured":"Rahul Srinivasan , Ben S Huang , Sharmila Venugopal , April D Johnston , Hua Chai , Hongkui Zeng , Peyman Golshani , and Baljit S Khakh . 2015. Ca 2+ signaling in astrocytes from Ip3r2-\/- mice in brain slices and during startle responses in vivo. Nature neuroscience 18, 5 ( 2015 ), 708--717. Rahul Srinivasan, Ben S Huang, Sharmila Venugopal, April D Johnston, Hua Chai, Hongkui Zeng, Peyman Golshani, and Baljit S Khakh. 2015. Ca 2+ signaling in astrocytes from Ip3r2-\/- mice in brain slices and during startle responses in vivo. Nature neuroscience 18, 5 (2015), 708--717."},{"key":"e_1_3_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neunet.2011.03.013"},{"key":"e_1_3_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3725"},{"key":"e_1_3_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.11.013"}],"event":{"name":"NANOCOM '21: The Eighth Annual ACM International Conference on Nanoscale Computing and Communication","sponsor":["SIGARCH ACM Special Interest Group on Computer Architecture"],"location":"Virtual Event Italy","acronym":"NANOCOM '21"},"container-title":["Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication"],"original-title":[],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3477206.3477460","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3477206.3477460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T20:49:04Z","timestamp":1750193344000},"score":1,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3477206.3477460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,7]]},"references-count":38,"alternative-id":["10.1145\/3477206.3477460","10.1145\/3477206"],"URL":"https:\/\/doi.org\/10.1145\/3477206.3477460","relation":{},"subject":[],"published":{"date-parts":[[2021,9,7]]},"assertion":[{"value":"2021-09-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}