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ACM Hum.-Comput. Interact."],"published-print":{"date-parts":[[2021,10,13]]},"abstract":"<jats:p>Co-design is a widely applied design process with well-documented values, including mutual learning and collective creativity. However, the real-world challenges of conducting multidisciplinary co-design research to inform the design of self-care technologies are not well established. We provide a qualitative account of a multidisciplinary project that aimed to co-design machine learning applications for Type 1 Diabetes (T1D) self-management. Through interviews, we identify not only perceived social, technological and strategic benefits of co-design but also organisational, translational and pragmatic design challenges: participants with T1D experienced difficulties in co-designing systems that met their individual self-care needs as part of group activities; HCI and AI researchers described challenges resulting from applying co-design outcomes to data-driven ML work; and industry collaborators highlighted academic data sharing regulations as cross-organisational challenges that can impede co-design efforts. 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