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It is a growing research domain that studies deployment, migration, and optimization of applications in the form of microservices across cloud\/edge infrastructure. It presents dynamically tailored microservices in technology-centric environments by exploiting edge and cloud platforms. Osmotic computing promotes digital transformation and furnishes benefits to transportation, smart cities, education, and healthcare. In this article, we present a comprehensive analysis of osmotic computing through a systematic literature review approach. To ensure high-quality review, we conduct an advanced search on numerous digital libraries to extracting related studies. The advanced search strategy identifies 99 studies, from which 29 relevant studies are selected for a thorough review. We present a summary of applications in osmotic computing build on their key features. On the basis of the observations, we outline the research challenges for the applications in this research field. Finally, we discuss the security issues resolved and unresolved in osmotic computing.<\/jats:p>","DOI":"10.1145\/3488247","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T11:43:11Z","timestamp":1644925391000},"page":"1-30","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":41,"title":["A Systematic Review on Osmotic Computing"],"prefix":"10.1145","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1713-9749","authenticated-orcid":false,"given":"Benazir","family":"Neha","sequence":"first","affiliation":[{"name":"Veer Surendra Sai University of Technology, Odisha, India"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3242-525X","authenticated-orcid":false,"given":"Sanjaya Kumar","family":"Panda","sequence":"additional","affiliation":[{"name":"National Institute of Technology, Warangal, Telangana, India"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7980-7928","authenticated-orcid":false,"given":"Pradip Kumar","family":"Sahu","sequence":"additional","affiliation":[{"name":"Veer Surendra Sai University of Technology, Odisha, India"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6435-5738","authenticated-orcid":false,"given":"Kshira Sagar","family":"Sahoo","sequence":"additional","affiliation":[{"name":"SRM University, Amaravati, AP, India"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2798-0104","authenticated-orcid":false,"given":"Amir H.","family":"Gandomi","sequence":"additional","affiliation":[{"name":"University of Technology Sydney, Australia"}]}],"member":"320","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1109\/ESEM.2009.5314235","volume-title":"Proceedings of the 3rd International Symposium on Empirical Software Engineering and Measurement (ESEM\u201909)","author":"Babar Muhammad Ali","year":"2009","unstructured":"Muhammad Ali Babar and He Zhang. 2009. 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