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Surv."],"published-print":{"date-parts":[[2023,2,28]]},"abstract":"<jats:p>\n                    <jats:bold>Alzheimer's Disease (AD)<\/jats:bold>\n                    is a devastating neurodegenerative brain disorder with no cure. An early identification helps patients with AD sustain a normal living. We have outlined\n                    <jats:bold>machine learning (ML)<\/jats:bold>\n                    methodologies with different schemes of feature extraction to synergize complementary and correlated characteristics of data acquired from multiple modalities of neuroimaging. A variety of feature selection, scaling, and fusion methodologies along with confronted challenges are elaborated for designing an ML-based AD diagnosis system. Additionally, thematic analysis has been provided to compare the ML workflow for possible diagnostic solutions. This comprehensive report adds value to the further advancement of computer-aided early diagnosis system based on multi-modal neuroimaging data from patients with AD.\n                  <\/jats:p>","DOI":"10.1145\/3492865","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T08:22:50Z","timestamp":1647246170000},"page":"1-44","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":68,"title":["A Comprehensive Report on Machine Learning-based Early Detection of Alzheimer's Disease using Multi-modal Neuroimaging Data"],"prefix":"10.1145","volume":"55","author":[{"given":"Shallu","family":"Sharma","sequence":"first","affiliation":[{"name":"Scientist, Neuroimaging and Neurospectroscopy Laboratory (NINS), NBRC, Manesar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4999-2808","authenticated-orcid":false,"given":"Pravat Kumar","family":"Mandal","sequence":"additional","affiliation":[{"name":"Neuroimaging and Neurospectroscopy Laboratory (NINS), NBRC, India and Florey Institute of Neuroscience and Mental Health, Melbourne School of Medicine Campus, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"320","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.001"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2011.0062"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","unstructured":"F. 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