{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:30:28Z","timestamp":1765960228090,"version":"3.41.0"},"publisher-location":"New York, NY, USA","reference-count":37,"publisher":"ACM","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.acm.org\/publications\/policies\/copyright_policy#Background"}],"funder":[{"name":"Program for International Science and Technology Cooperation Projects of Shaanxi Province","award":["2021KW-63"],"award-info":[{"award-number":["2021KW-63"]}]}],"content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10,17]]},"DOI":"10.1145\/3511808.3557318","type":"proceedings-article","created":{"date-parts":[[2022,10,16]],"date-time":"2022-10-16T01:22:22Z","timestamp":1665883342000},"page":"884-893","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Extracting Drug-drug Interactions from Biomedical Texts using Knowledge Graph Embeddings and Multi-focal Loss"],"prefix":"10.1145","author":[{"given":"Xin","family":"Jin","sequence":"first","affiliation":[{"name":"Northwest University, Xi'an, China"}]},{"given":"Xia","family":"Sun","sequence":"additional","affiliation":[{"name":"Northwest University, Xi'an, China"}]},{"given":"Jiacheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Northwest University, Xi'an, China"}]},{"given":"Richard","family":"Sutcliffe","sequence":"additional","affiliation":[{"name":"Northwest University & University of Essex, Colchester, United Kingdom"}]}],"member":"320","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"e_1_3_2_1_1_1","volume-title":"Sep","author":"Miranda Vanessa","year":"2011","unstructured":"Vanessa Miranda , Angelo Fede , Melissa Nobuo , Veronica Ayres , Auro Giglio , Michele Miranda , and Rachel P Riechelmann . Adverse drug reactions and drug interactions as causes of hospital admission in oncology. Journal of pain and symptom management, 42(3):342--353 , Sep 2011 . Vanessa Miranda, Angelo Fede, Melissa Nobuo, Veronica Ayres, Auro Giglio, Michele Miranda, and Rachel P Riechelmann. Adverse drug reactions and drug interactions as causes of hospital admission in oncology. Journal of pain and symptom management, 42(3):342--353, Sep 2011."},{"key":"e_1_3_2_1_2_1","volume-title":"Proceedings of the 2019 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, NAACL-HLT 2019","volume":"1","author":"Devlin Jacob","year":"2019","unstructured":"Jacob Devlin , Ming-Wei Chang , Kenton Lee , and Kristina Toutanova . BERT : pre-training of deep bidirectional transformers for language understanding . In Proceedings of the 2019 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, NAACL-HLT 2019 , Minneapolis, MN, USA , June 2-7, 2019 , Volume 1 (Long and Short Papers), pages 4171--4186. Association for Computational Linguistics, Jun 2019. Jacob Devlin, Ming-Wei Chang, Kenton Lee, and Kristina Toutanova. BERT: pre-training of deep bidirectional transformers for language understanding. In Proceedings of the 2019 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, NAACL-HLT 2019, Minneapolis, MN, USA, June 2-7, 2019, Volume 1 (Long and Short Papers), pages 4171--4186. Association for Computational Linguistics, Jun 2019."},{"key":"e_1_3_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz682"},{"key":"e_1_3_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.18653\/v1\/D19-1371"},{"key":"e_1_3_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.18653\/v1\/2020.bionlp-1.22"},{"key":"e_1_3_2_1_6_1","volume-title":"Jan","author":"Gu Yu","year":"2021","unstructured":"Yu Gu , Robert Tinn , Hao Cheng , Michael Lucas , Naoto Usuyama , Xiaodong Liu , Tristan Naumann , Jianfeng Gao , and Hoifung Poon . Domain-specific language model pretraining for biomedical natural language processing. ACM Transactions on Computing for Healthcare (HEALTH), 3(1):1--23 , Jan 2021 . Yu Gu, Robert Tinn, Hao Cheng, Michael Lucas, Naoto Usuyama, Xiaodong Liu, Tristan Naumann, Jianfeng Gao, and Hoifung Poon. Domain-specific language model pretraining for biomedical natural language processing. ACM Transactions on Computing for Healthcare (HEALTH), 3(1):1--23, Jan 2021."},{"key":"e_1_3_2_1_7_1","volume-title":"Jun","author":"Zhu Yu","year":"2020","unstructured":"Yu Zhu , Lishuang Li , Hongbin Lu , Anqiao Zhou , and Xueyang Qin . Extracting drug-drug interactions from texts with biobert and multiple entity-aware attentions. Journal of biomedical informatics, 106:103451 , Jun 2020 . Yu Zhu, Lishuang Li, Hongbin Lu, Anqiao Zhou, and Xueyang Qin. Extracting drug-drug interactions from texts with biobert and multiple entity-aware attentions. Journal of biomedical informatics, 106:103451, Jun 2020."},{"key":"e_1_3_2_1_8_1","volume-title":"Drugbank 5.0: a major update to the drugbank database for","author":"Wishart David S","year":"2018","unstructured":"David S Wishart , Yannick D Feunang , An C Guo , Elvis J Lo , Ana Marcu , Jason R Grant , Tanvir Sajed , Daniel Johnson , Carin Li , Zinat Sayeeda , Drugbank 5.0: a major update to the drugbank database for 2018 . Nucleic acids research, 46(D1):D1074-D1082, Jan 2018. David S Wishart, Yannick D Feunang, An C Guo, Elvis J Lo, Ana Marcu, Jason R Grant, Tanvir Sajed, Daniel Johnson, Carin Li, Zinat Sayeeda, et al. Drugbank 5.0: a major update to the drugbank database for 2018. Nucleic acids research, 46(D1):D1074-D1082, Jan 2018."},{"key":"e_1_3_2_1_9_1","volume-title":"Second Joint Conference on Lexical and Computational Semantics (*SEM)","volume":"350","author":"Segura-Bedmar Isabel","year":"2013","unstructured":"Isabel Segura-Bedmar , Paloma Mart\u00ednez Fern\u00e1ndez , and Mar\u00eda Herrero Zazo . Semeval-2013 task 9 : Extraction of drug-drug interactions from biomedical texts (ddiextraction 2013) . In Second Joint Conference on Lexical and Computational Semantics (*SEM) , Volume 2: Seventh International Workshop on Semantic Evaluation (SemEval 2013), pp. 341-- 350 , Atlanta, Georgia, USA , Jun 2013 . Association for Computational Linguistics, ACL. Isabel Segura-Bedmar, Paloma Mart\u00ednez Fern\u00e1ndez, and Mar\u00eda Herrero Zazo. Semeval-2013 task 9: Extraction of drug-drug interactions from biomedical texts (ddiextraction 2013). In Second Joint Conference on Lexical and Computational Semantics (*SEM), Volume 2: Seventh International Workshop on Semantic Evaluation (SemEval 2013), pp. 341--350, Atlanta, Georgia, USA, Jun 2013. Association for Computational Linguistics, ACL."},{"key":"e_1_3_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/bay060"},{"key":"e_1_3_2_1_11_1","first-page":"351","volume-title":"Second Joint Conference on Lexical and Computational Semantics (*SEM)","volume":"2","author":"Mahbub Chowdhury Md Faisal","year":"2013","unstructured":"Md Faisal Mahbub Chowdhury and Alberto Lavelli . Fbk-irst : A multi-phase kernel based approach for drug-drug interaction detection and classification that exploits linguistic information . In Second Joint Conference on Lexical and Computational Semantics (*SEM) , Volume 2: Proceedings of the Seventh International Workshop on Semantic Evaluation (SemEval 2013), volume 2 , pages 351 -- 355 , Atlanta, Georgia, USA , June 2013 . Md Faisal Mahbub Chowdhury and Alberto Lavelli. Fbk-irst: A multi-phase kernel based approach for drug-drug interaction detection and classification that exploits linguistic information. In Second Joint Conference on Lexical and Computational Semantics (*SEM), Volume 2: Proceedings of the Seventh International Workshop on Semantic Evaluation (SemEval 2013), volume 2, pages 351--355, Atlanta, Georgia, USA, June 2013."},{"key":"e_1_3_2_1_12_1","first-page":"628","volume-title":"Second Joint Conference on Lexical and Computational Semantics (* SEM)","volume":"2","author":"Thomas Philippe","year":"2013","unstructured":"Philippe Thomas , Mariana Neves , Tim Rockt\u00e4schel , and Ulf Leser . Wbi-ddi : drug- drug interaction extraction using majority voting . In Second Joint Conference on Lexical and Computational Semantics (* SEM) , Volume 2: Proceedings of the Seventh International Workshop on Semantic Evaluation (SemEval 2013), volume 2 , pages 628 -- 635 , Atlanta, Georgia, USA , June 2013 . Philippe Thomas, Mariana Neves, Tim Rockt\u00e4schel, and Ulf Leser. Wbi-ddi: drug- drug interaction extraction using majority voting. In Second Joint Conference on Lexical and Computational Semantics (* SEM), Volume 2: Proceedings of the Seventh International Workshop on Semantic Evaluation (SemEval 2013), volume 2, pages 628--635, Atlanta, Georgia, USA, June 2013."},{"key":"e_1_3_2_1_13_1","first-page":"644","volume-title":"Second Joint Conference on Lexical and Computational Semantics (* SEM)","volume":"2","author":"Bokharaeian Behrouz","year":"2013","unstructured":"Behrouz Bokharaeian and Alberto D\u00edaz . Nil_ucm : Extracting drug-drug interactions from text through combination of sequence and tree kernels . In Second Joint Conference on Lexical and Computational Semantics (* SEM) , Volume 2: Proceedings of the Seventh International Workshop on Semantic Evaluation (SemEval 2013), volume 2 , pages 644 -- 650 , Atlanta, Georgia, USA , June 2013 . Behrouz Bokharaeian and Alberto D\u00edaz. Nil_ucm: Extracting drug-drug interactions from text through combination of sequence and tree kernels. In Second Joint Conference on Lexical and Computational Semantics (* SEM), Volume 2: Proceedings of the Seventh International Workshop on Semantic Evaluation (SemEval 2013), volume 2, pages 644--650, Atlanta, Georgia, USA, June 2013."},{"key":"e_1_3_2_1_14_1","volume-title":"Extracting drug--drug interactions from literature using a rich feature-based linear kernel approach. Journal of biomedical informatics, 55:23--30","author":"Kim Sun","year":"2015","unstructured":"Sun Kim , Haibin Liu , Lana Yeganova , and W John Wilbur . Extracting drug--drug interactions from literature using a rich feature-based linear kernel approach. Journal of biomedical informatics, 55:23--30 , 2015 . Sun Kim, Haibin Liu, Lana Yeganova, and W John Wilbur. Extracting drug--drug interactions from literature using a rich feature-based linear kernel approach. Journal of biomedical informatics, 55:23--30, 2015."},{"issue":"1","key":"e_1_3_2_1_15_1","first-page":"109","article-title":"Extracting drug-drug interactions from biomedical text using a feature-based kernel approach","volume":"92","author":"Raihani Anass","year":"2016","unstructured":"Anass Raihani and Nabil Laachfoubi . Extracting drug-drug interactions from biomedical text using a feature-based kernel approach . Journal of Theoretical and Applied Information Technology , 92 ( 1 ): 109 , 2016 . Anass Raihani and Nabil Laachfoubi. Extracting drug-drug interactions from biomedical text using a feature-based kernel approach. Journal of Theoretical and Applied Information Technology, 92(1):109, 2016.","journal-title":"Journal of Theoretical and Applied Information Technology"},{"key":"e_1_3_2_1_16_1","volume-title":"Drug-drug interaction extraction via convolutional neural networks. Computational and mathematical methods in medicine","author":"Liu Shengyu","year":"2016","unstructured":"Shengyu Liu , Buzhou Tang , Qingcai Chen , and Xiaolong Wang . Drug-drug interaction extraction via convolutional neural networks. Computational and mathematical methods in medicine , 2016 , 2016. Shengyu Liu, Buzhou Tang, Qingcai Chen, and Xiaolong Wang. Drug-drug interaction extraction via convolutional neural networks. Computational and mathematical methods in medicine, 2016, 2016."},{"key":"e_1_3_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1109\/BIBM.2016.7822671"},{"key":"e_1_3_2_1_18_1","volume-title":"Madrid","author":"Sun Xia","year":"2018","unstructured":"Xia Sun , Long Ma , Xiaodong Du , Jun Feng , and Ke Dong . Deep convolution neural networks for drug-drug interaction extraction. In 2018 ieee international conference on bioinformatics and biomedicine (bibm), pages 1662--1668 , Madrid , Spain , Dec 2018 . IEEE, IEEE. Xia Sun, Long Ma, Xiaodong Du, Jun Feng, and Ke Dong. Deep convolution neural networks for drug-drug interaction extraction. In 2018 ieee international conference on bioinformatics and biomedicine (bibm), pages 1662--1668, Madrid, Spain, Dec 2018. IEEE, IEEE."},{"key":"e_1_3_2_1_19_1","first-page":"9","volume-title":"BioNLP","author":"Asada Masaki","year":"2017","unstructured":"Masaki Asada , Makoto Miwa , and Yutaka Sasaki . Extracting drug-drug interac- tions with attention cnns . In BioNLP 2017 , pages 9 -- 18 , Vancouver, Canada, Aug 2017. ACL, Association for Computational Linguistics . Masaki Asada, Makoto Miwa, and Yutaka Sasaki. Extracting drug-drug interac- tions with attention cnns. In BioNLP 2017, pages 9--18, Vancouver, Canada, Aug 2017. ACL, Association for Computational Linguistics."},{"key":"e_1_3_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1109\/ICHI.2017.15"},{"issue":"16","key":"e_1_3_2_1_21_1","first-page":"99","article-title":"Dependency-based long short term memory network for drug-drug interaction extraction","volume":"18","author":"Wang Wei","year":"2017","unstructured":"Wei Wang , Xi Yang , Canqun Yang , Xiaowei Guo , Xiang Zhang , and Chengkun Wu . Dependency-based long short term memory network for drug-drug interaction extraction . BMC bioinformatics , 18 ( 16 ): 99 -- 109 , Dec 2017 . Wei Wang, Xi Yang, Canqun Yang, Xiaowei Guo, Xiang Zhang, and Chengkun Wu. Dependency-based long short term memory network for drug-drug interaction extraction. BMC bioinformatics, 18(16):99--109, Dec 2017.","journal-title":"BMC bioinformatics"},{"key":"e_1_3_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-017-1855-x"},{"key":"e_1_3_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/e21010037"},{"key":"e_1_3_2_1_24_1","volume-title":"Madrid","author":"Xu Bo","year":"2018","unstructured":"Bo Xu , Xiufeng Shi , Zhehuan Zhao , Wei Zheng , Hongfei Lin , Zhihao Yang , Jian Wang , and Feng Xia . Full-attention based drug drug interaction extraction exploit- ing user-generated content. In 2018 ieee international conference on bioinformatics and biomedicine (bibm), pages 560--565 , Madrid , Spain , Jan 2018 . IEEE, IEEE. Bo Xu, Xiufeng Shi, Zhehuan Zhao, Wei Zheng, Hongfei Lin, Zhihao Yang, Jian Wang, and Feng Xia. Full-attention based drug drug interaction extraction exploit- ing user-generated content. In 2018 ieee international conference on bioinformatics and biomedicine (bibm), pages 560--565, Madrid, Spain, Jan 2018. IEEE, IEEE."},{"key":"e_1_3_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa907"},{"key":"e_1_3_2_1_26_1","volume-title":"Jan","author":"Huang Lei","year":"2022","unstructured":"Lei Huang , Jiecong Lin , Xiangtao Li , Linqi Song , Zetian Zheng , and Ka-Chun Wong . Egfi: drug--drug interaction extraction and generation with fusion of enriched entity and sentence information. Briefings in Bioinformatics, 23(1):bbab451 , Jan 2022 . Lei Huang, Jiecong Lin, Xiangtao Li, Linqi Song, Zetian Zheng, and Ka-Chun Wong. Egfi: drug--drug interaction extraction and generation with fusion of enriched entity and sentence information. Briefings in Bioinformatics, 23(1):bbab451, Jan 2022."},{"key":"e_1_3_2_1_27_1","volume-title":"SDU@ AAAI","author":"Mondal Ishani","year":"2021","unstructured":"Ishani Mondal . Bertkg-ddi: Towards incorporating entity-specific knowledge graph information in predicting drug-drug interactions . In SDU@ AAAI , Feb 2021 . Ishani Mondal. Bertkg-ddi: Towards incorporating entity-specific knowledge graph information in predicting drug-drug interactions. In SDU@ AAAI, Feb 2021."},{"key":"e_1_3_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.18653\/v1\/D18-2012"},{"key":"e_1_3_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.18653\/v1\/2020.acl-demos.14"},{"key":"e_1_3_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.18653\/v1\/P19-1356"},{"key":"e_1_3_2_1_31_1","volume-title":"Translating embeddings for modeling multi-relational data. Advances in neural information processing systems, 26","author":"Bordes Antoine","year":"2013","unstructured":"Antoine Bordes , Nicolas Usunier , Alberto Garcia-Duran , Jason Weston , and Oksana Yakhnenko . Translating embeddings for modeling multi-relational data. Advances in neural information processing systems, 26 , 2013 . Antoine Bordes, Nicolas Usunier, Alberto Garcia-Duran, Jason Weston, and Oksana Yakhnenko. Translating embeddings for modeling multi-relational data. Advances in neural information processing systems, 26, 2013."},{"key":"e_1_3_2_1_32_1","volume-title":"3rd International Conference on Learning Representations, ICLR 2015, San Diego, CA, USA, May 7-9, 2015, Conference Track Proceedings","author":"Yang Bishan","year":"2015","unstructured":"Bishan Yang , Wen-tau Yih, Xiaodong He , Jianfeng Gao , and Li Deng . Embedding entities and relations for learning and inference in knowledge bases . In 3rd International Conference on Learning Representations, ICLR 2015, San Diego, CA, USA, May 7-9, 2015, Conference Track Proceedings , May 2015 . Bishan Yang, Wen-tau Yih, Xiaodong He, Jianfeng Gao, and Li Deng. Embedding entities and relations for learning and inference in knowledge bases. In 3rd International Conference on Learning Representations, ICLR 2015, San Diego, CA, USA, May 7-9, 2015, Conference Track Proceedings, May 2015."},{"key":"e_1_3_2_1_33_1","first-page":"2071","volume-title":"International conference on machine learning","volume":"48","author":"Trouillon Th\u00e9o","year":"2016","unstructured":"Th\u00e9o Trouillon , Johannes Welbl , Sebastian Riedel , \u00c9ric Gaussier , and Guillaume Bouchard . Complex embeddings for simple link prediction . In International conference on machine learning , volume 48 , pages 2071 -- 2080 . PMLR, PMLR, Jun 2016 . Th\u00e9o Trouillon, Johannes Welbl, Sebastian Riedel, \u00c9ric Gaussier, and Guillaume Bouchard. Complex embeddings for simple link prediction. In International conference on machine learning, volume 48, pages 2071--2080. PMLR, PMLR, Jun 2016."},{"key":"e_1_3_2_1_34_1","volume-title":"7th International Conference on Learning Representations, ICLR 2019","author":"Sun Zhiqing","year":"2019","unstructured":"Zhiqing Sun , Zhi-Hong Deng , Jian-Yun Nie , and Jian Tang . Rotate : Knowledge graph embedding by relational rotation in complex space . In 7th International Conference on Learning Representations, ICLR 2019 , New Orleans, LA, USA , May 6-9, 2019 . OpenReview.net, May 2019. Zhiqing Sun, Zhi-Hong Deng, Jian-Yun Nie, and Jian Tang. Rotate: Knowledge graph embedding by relational rotation in complex space. In 7th International Conference on Learning Representations, ICLR 2019, New Orleans, LA, USA, May 6-9, 2019. OpenReview.net, May 2019."},{"key":"e_1_3_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1109\/ICCV.2017.324"},{"key":"e_1_3_2_1_36_1","volume-title":"Attention is all you need. Advances in neural information processing systems, 30","author":"Vaswani Ashish","year":"2017","unstructured":"Ashish Vaswani , Noam Shazeer , Niki Parmar , Jakob Uszkoreit , Llion Jones , Aidan N Gomez , \u0141ukasz Kaiser , and Illia Polosukhin . Attention is all you need. Advances in neural information processing systems, 30 , 2017 . Ashish Vaswani, Noam Shazeer, Niki Parmar, Jakob Uszkoreit, Llion Jones, Aidan N Gomez, \u0141ukasz Kaiser, and Illia Polosukhin. Attention is all you need. Advances in neural information processing systems, 30, 2017."},{"key":"e_1_3_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.18653\/v1\/2021.bionlp-1.1"}],"event":{"name":"CIKM '22: The 31st ACM International Conference on Information and Knowledge Management","sponsor":["SIGWEB ACM Special Interest Group on Hypertext, Hypermedia, and Web","SIGIR ACM Special Interest Group on Information Retrieval"],"location":"Atlanta GA USA","acronym":"CIKM '22"},"container-title":["Proceedings of the 31st ACM International Conference on Information & Knowledge Management"],"original-title":[],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3511808.3557318","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3511808.3557318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T17:49:28Z","timestamp":1750182568000},"score":1,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3511808.3557318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,17]]},"references-count":37,"alternative-id":["10.1145\/3511808.3557318","10.1145\/3511808"],"URL":"https:\/\/doi.org\/10.1145\/3511808.3557318","relation":{},"subject":[],"published":{"date-parts":[[2022,10,17]]},"assertion":[{"value":"2022-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}