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This is further used to develop a novel Content-based Medical Image Retrieval framework. The developed framework uses DenseNet-201 architecture for generating the image descriptors. Then for classification, the optimized Deep Neural Network model has been configured through a population-based metaheuristic Differential Evolution. Differential Evolution iteratively performs the joint optimization of hyperparameters and architecture of Deep Neural Networks. The competence of the proposed model is validated on three publicly available datasets: Brain Tumor MRI dataset, Covid-19 Radiography database, and Breast Cancer MRI dataset, and by comparing it with selected models over different aspects of performance evaluation. 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