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To minimize casualties and the impact on the economy, various mitigation measures have being employed with the purpose to slow the spread of the infection, such as complete lockdown, social distancing, and random testing. The key contribution of this article is twofold. First, we present a novel extended spatially informed epidemic model,\n            <jats:italic>SIRTEM, Spatially Informed Rapid Testing for Epidemic Modeling and Response to COVID-19<\/jats:italic>\n            , that integrates a multi-modal testing strategy considering test accuracies. Our second contribution is an optimization model to provide a cost-effective testing strategy when multiple test types are available. The developed optimization model incorporates realistic spatially based constraints, such as testing capacity and hospital bed limitation as well.\n          <\/jats:p>","DOI":"10.1145\/3555310","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T11:40:18Z","timestamp":1660045218000},"page":"1-43","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["SIRTEM: Spatially Informed Rapid Testing for Epidemic Modeling and Response to COVID-19"],"prefix":"10.1145","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5225-9602","authenticated-orcid":false,"given":"Fahim Tasneema","family":"Azad","sequence":"first","affiliation":[{"name":"School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6653-9701","authenticated-orcid":false,"given":"Robert W.","family":"Dodge","sequence":"additional","affiliation":[{"name":"School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0053-1728","authenticated-orcid":false,"given":"Allen M.","family":"Varghese","sequence":"additional","affiliation":[{"name":"School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9954-4072","authenticated-orcid":false,"given":"Jaejin","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6726-9790","authenticated-orcid":false,"given":"Giulia","family":"Pedrielli","sequence":"additional","affiliation":[{"name":"School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4977-6646","authenticated-orcid":false,"given":"K. 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