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Recently, an unprecedented amount of spatial and spatiotemporal data have been made available that can be used to improve our understanding of the spread of COVID-19 and other infectious diseases. This understanding will be paramount to prepare for future pandemics through spatial algorithms and systems to collect, capture, curate, and analyze complex, multi-scale human movement data to solve problems such as infectious diseases prediction, contact tracing, and risk assessment. In exploring and deepening the conversation around this topic, the eight articles included in the first volume of this special issue employ diverse theoretical perspectives, methodologies, and frameworks, including but not limited to infectious diseases simulation, risk prediction, response policy design, mobility analysis, and case diagnosis. 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