{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T05:01:25Z","timestamp":1750309285476,"version":"3.41.0"},"publisher-location":"New York, NY, USA","reference-count":34,"publisher":"ACM","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.acm.org\/publications\/policies\/copyright_policy#Background"}],"content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12,26]]},"DOI":"10.1145\/3589437.3589442","type":"proceedings-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T16:20:20Z","timestamp":1689870020000},"page":"27-34","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Research on Cell Aging Based on Reprogramming Senescent Cells by Inhibiting Pro-Inflammatory TNF\/Edn1 Pathway as a Potential Treatment of Age-Related Diseases"],"prefix":"10.1145","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8333-8014","authenticated-orcid":false,"given":"Siwen","family":"Cui","sequence":"first","affiliation":[{"name":"Kent School, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5220-2881","authenticated-orcid":false,"given":"Virgia","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University, China"}]}],"member":"320","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"e_1_3_2_1_1_1","first-page":"R458","volume":"201","author":"Ferrell JE, Jr","unstructured":"Ferrell JE, Jr . Bistability , bifurcations, and Waddington's epigenetic landscape. Curr Biol. 201 2;22(11): R458 - R466 . Ferrell JE, Jr. Bistability, bifurcations, and Waddington's epigenetic landscape. Curr Biol. 2012;22(11):R458-66.","journal-title":"Curr Biol."},{"key":"e_1_3_2_1_2_1","first-page":"663","volume":"200","author":"Takahashi K","unstructured":"Takahashi K , Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 200 6;126(4): 663 - 676 . Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663-76.","journal-title":"Cell."},{"key":"e_1_3_2_1_3_1","first-page":"1719","volume":"201","author":"Ocampo A","unstructured":"Ocampo A , Reddy P , Martinez-Redondo P , Platero-Luengo A , Hatanaka F , Hishida T , In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. Cell. 201 6;167(7): 1719 - 1733 e12. Ocampo A, Reddy P, Martinez-Redondo P, Platero-Luengo A, Hatanaka F, Hishida T, In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. Cell. 2016;167(7):1719-33 e12.","journal-title":"Partial Reprogramming. Cell."},{"key":"e_1_3_2_1_4_1","first-page":"124","volume":"202","author":"Lu Y","unstructured":"Lu Y , Brommer B , Tian X , Krishnan A , Meer M , Wang C , Reprogramming to recover youthful epigenetic information and restore vision. Nature. 202 0;588(7836): 124 - 129 . Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020;588(7836):124-9.","journal-title":"Nature."},{"key":"e_1_3_2_1_5_1","first-page":"553","volume":"201","author":"Mahmoudi S","unstructured":"Mahmoudi S , Mancini E , Xu L , Moore A , Jahanbani F , Hebestreit K , Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Nature. 201 9;574(7779): 553 - 558 . Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Nature. 2019;574(7779):553-8.","journal-title":"Nature."},{"key":"e_1_3_2_1_6_1","doi-asserted-by":"crossref","unstructured":"Sarkar TJ Quarta M Mukherjee S Colville A Paine P Doan L Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells. Nat Commun. 2020;11(1):1545.  Sarkar TJ Quarta M Mukherjee S Colville A Paine P Doan L Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells. Nat Commun. 2020;11(1):1545.","DOI":"10.1038\/s41467-020-15174-3"},{"key":"e_1_3_2_1_7_1","first-page":"1194","volume":"201","author":"Lopez-Otin C","unstructured":"Lopez-Otin C , Blasco MA , Partridge L , Serrano M , Kroemer G. The hallmarks of aging. Cell. 201 3;153(6): 1194 - 1217 . Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194-217.","journal-title":"Cell."},{"key":"e_1_3_2_1_8_1","first-page":"713","volume":"201","author":"Soria-Valles C","unstructured":"Soria-Valles C , Lopez-Otin C. iPS Cs : On the Road to Reprogramming Aging. Trends Mol Med. 201 6;22(8): 713 - 724 . Soria-Valles C, Lopez-Otin C. iPSCs: On the Road to Reprogramming Aging. Trends Mol Med. 2016;22(8):713-24.","journal-title":"Reprogramming Aging. Trends Mol Med."},{"key":"e_1_3_2_1_9_1","first-page":"3244","volume":"200","author":"Adler AS","unstructured":"Adler AS , Sinha S , Kawahara TL , Zhang JY , Segal E , Chang HY. Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev. 200 7;21(24): 3244 - 3257 . Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E, Chang HY. Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev. 2007;21(24):3244-57.","journal-title":"Genes Dev."},{"key":"e_1_3_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.19.2434"},{"key":"e_1_3_2_1_11_1","doi-asserted-by":"crossref","unstructured":"Rosano L Spinella F Bagnato A. Endothelin 1 in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer. 2013;13(9):637-51.  Rosano L Spinella F Bagnato A. Endothelin 1 in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer. 2013;13(9):637-51.","DOI":"10.1038\/nrc3546"},{"key":"e_1_3_2_1_12_1","first-page":"247","volume":"199","author":"Ihara M","unstructured":"Ihara M , Noguchi K , Saeki T , Fukuroda T , Tsuchida S , Kimura S , Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor. Life Sci. 199 2;50(4): 247 - 255 . Ihara M, Noguchi K, Saeki T, Fukuroda T, Tsuchida S, Kimura S, Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor. Life Sci. 1992;50(4):247-55.","journal-title":"Life Sci."},{"key":"e_1_3_2_1_13_1","doi-asserted-by":"crossref","unstructured":"Yeager ME Belchenko DD Nguyen CM Colvin KL Ivy DD Stenmark KR. Endothelin-1 the unfolded protein response and persistent inflammation: role of pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol. 2012;46(1):14-22.  Yeager ME Belchenko DD Nguyen CM Colvin KL Ivy DD Stenmark KR. Endothelin-1 the unfolded protein response and persistent inflammation: role of pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol. 2012;46(1):14-22.","DOI":"10.1165\/rcmb.2010-0506OC"},{"key":"e_1_3_2_1_14_1","first-page":"556","volume":"200","author":"Scalera F","unstructured":"Scalera F , Dittrich R , Beckmann MW , Beinder E. Effect of endothelin-1 on intracellular glutathione and lipid peroxide availability and on the secretion of vasoactive substances by human umbilical vein endothelial cells. Eur J Clin Invest. 200 2;32(8): 556 - 562 . Scalera F, Dittrich R, Beckmann MW, Beinder E. Effect of endothelin-1 on intracellular glutathione and lipid peroxide availability and on the secretion of vasoactive substances by human umbilical vein endothelial cells. Eur J Clin Invest. 2002;32(8):556-62.","journal-title":"Eur J Clin Invest."},{"key":"e_1_3_2_1_15_1","first-page":"323","volume":"200","author":"Dong F","unstructured":"Dong F , Zhang X , Wold LE , Ren Q , Zhang Z , Ren J. Endothelin -1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ETB receptor, NADPH oxidase and caveolin-1. Br J Pharmacol. 200 5;145(3): 323 - 333 . Dong F, Zhang X, Wold LE, Ren Q, Zhang Z, Ren J. Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ETB receptor, NADPH oxidase and caveolin-1. Br J Pharmacol. 2005;145(3):323-33.","journal-title":"Br J Pharmacol."},{"key":"e_1_3_2_1_16_1","doi-asserted-by":"crossref","unstructured":"Singh PB Newman AG. Age reprogramming and epigenetic rejuvenation. Epigenetics Chromatin. 2018;11(1):73.  Singh PB Newman AG. Age reprogramming and epigenetic rejuvenation. Epigenetics Chromatin. 2018;11(1):73.","DOI":"10.1186\/s13072-018-0244-7"},{"key":"e_1_3_2_1_17_1","doi-asserted-by":"crossref","unstructured":"Kerepesi C Zhang B Lee SG Trapp A Gladyshev VN. Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging. Sci Adv. 2021;7(26).  Kerepesi C Zhang B Lee SG Trapp A Gladyshev VN. Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging. Sci Adv. 2021;7(26).","DOI":"10.1126\/sciadv.abg6082"},{"key":"e_1_3_2_1_18_1","doi-asserted-by":"crossref","unstructured":"Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):R115.  Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):R115.","DOI":"10.1186\/gb-2013-14-10-r115"},{"key":"e_1_3_2_1_19_1","first-page":"737","volume":"201","author":"Sanese P","unstructured":"Sanese P , Forte G , Disciglio V , Grossi V , Simone C. FOXO3 on the Road to Longevity: Lessons From SNPs and Chromatin Hubs. Comput Struct Biotechnol J. 201 9;17: 737 - 745 . Sanese P, Forte G, Disciglio V, Grossi V, Simone C. FOXO3 on the Road to Longevity: Lessons From SNPs and Chromatin Hubs. Comput Struct Biotechnol J. 2019;17:737-45.","journal-title":"Chromatin Hubs. Comput Struct Biotechnol J."},{"key":"e_1_3_2_1_20_1","first-page":"S4","volume":"201","author":"Franceschi C","unstructured":"Franceschi C , Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 201 4;69 Suppl 1: S4 - S9 . Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69 Suppl 1:S4-9.","journal-title":"Biol Sci Med Sci."},{"key":"e_1_3_2_1_21_1","first-page":"125","volume":"201","author":"Maguire JJ","unstructured":"Maguire JJ , Davenport AP. Endothelin receptors and their antagonists. Semin Nephrol. 201 5;35(2): 125 - 136 . Maguire JJ, Davenport AP. Endothelin receptors and their antagonists. Semin Nephrol. 2015;35(2):125-36.","journal-title":"Semin Nephrol."},{"key":"e_1_3_2_1_22_1","first-page":"S11","volume":"199","author":"Ihara M","unstructured":"Ihara M , Ishikawa K , Fukuroda T , Saeki T , Funabashi K , Fukami T , In vitro biological profile of a highly potent novel endothelin (ET) antagonist BQ-123 selective for the ETA receptor. J Cardiovasc Pharmacol. 199 2;20 Suppl 12: S11 - S14 . Ihara M, Ishikawa K, Fukuroda T, Saeki T, Funabashi K, Fukami T, In vitro biological profile of a highly potent novel endothelin (ET) antagonist BQ-123 selective for the ETA receptor. J Cardiovasc Pharmacol. 1992;20 Suppl 12:S11-4.","journal-title":"J Cardiovasc Pharmacol."},{"key":"e_1_3_2_1_23_1","first-page":"1576","volume":"200","author":"Ford RL","unstructured":"Ford RL , Mains IM , Hilton EJ , Reeves ST , Stroud RE , Crawford FA, Jr. , Endothelin -A receptor inhibition after cardiopulmonary bypass: cytokines and receptor activation. Ann Thorac Surg. 200 8;86(5): 1576 - 1583 . Ford RL, Mains IM, Hilton EJ, Reeves ST, Stroud RE, Crawford FA, Jr., Endothelin-A receptor inhibition after cardiopulmonary bypass: cytokines and receptor activation. Ann Thorac Surg. 2008;86(5):1576-83.","journal-title":"Ann Thorac Surg."},{"key":"e_1_3_2_1_24_1","first-page":"904","volume":"201","author":"Chen Y","unstructured":"Chen Y , Hanaoka M , Droma Y , Chen P , Voelkel NF , Kubo K. Endothelin -1 receptor antagonists prevent the development of pulmonary emphysema in rats. Eur Respir J. 201 0;35(4): 904 - 912 . Chen Y, Hanaoka M, Droma Y, Chen P, Voelkel NF, Kubo K. Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats. Eur Respir J. 2010;35(4):904-12.","journal-title":"Eur Respir J."},{"key":"e_1_3_2_1_25_1","first-page":"37","volume":"200","author":"Xu H","unstructured":"Xu H , Lin L , Yuan WJ. Antiarrhythmic effect of endothelin-A receptor antagonist on acute ischemic arrhythmia in isolated rat heart. Acta Pharmacol Sin. 200 3;24(1): 37 - 44 . Xu H, Lin L, Yuan WJ. Antiarrhythmic effect of endothelin-A receptor antagonist on acute ischemic arrhythmia in isolated rat heart. Acta Pharmacol Sin. 2003;24(1):37-44.","journal-title":"Acta Pharmacol Sin."},{"key":"e_1_3_2_1_26_1","first-page":"4892","volume":"199","author":"Ishikawa K","unstructured":"Ishikawa K , Ihara M , Noguchi K , Mase T , Mino N , Saeki T , Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788. Proc Natl Acad Sci U S A. 199 4;91(11): 4892 - 4896 . Ishikawa K, Ihara M, Noguchi K, Mase T, Mino N, Saeki T, Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788. Proc Natl Acad Sci U S A. 1994;91(11):4892-6.","journal-title":"Proc Natl Acad Sci U S A."},{"key":"e_1_3_2_1_27_1","first-page":"3490","volume":"201","author":"Tonari M","unstructured":"Tonari M , Kurimoto T , Horie T , Sugiyama T , Ikeda T , Oku H. Blocking endothelin-B receptors rescues retinal ganglion cells from optic nerve injury through suppression of neuroinflammation. Invest Ophthalmol Vis Sci. 201 2;53(7): 3490 - 3500 . Tonari M, Kurimoto T, Horie T, Sugiyama T, Ikeda T, Oku H. Blocking endothelin-B receptors rescues retinal ganglion cells from optic nerve injury through suppression of neuroinflammation. Invest Ophthalmol Vis Sci. 2012;53(7):3490-500.","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"e_1_3_2_1_28_1","first-page":"271","volume":"201","author":"Piechota-Polanczyk A","unstructured":"Piechota-Polanczyk A , Kleniewska P , Goraca A. The influence of ETA and ETB receptor blockers on LPS-induced oxidative stress and NF-kappaB signaling pathway in heart. Gen Physiol Biophys. 201 2;31(3): 271 - 278 . Piechota-Polanczyk A, Kleniewska P, Goraca A. The influence of ETA and ETB receptor blockers on LPS-induced oxidative stress and NF-kappaB signaling pathway in heart. Gen Physiol Biophys. 2012;31(3):271-8.","journal-title":"Gen Physiol Biophys."},{"key":"e_1_3_2_1_29_1","first-page":"1347","volume":"200","author":"Chen CH","unstructured":"Chen CH , Cheng TH , Lin H , Shih NL , Chen YL , Chen YS , Reactive oxygen species generation is involved in epidermal growth factor receptor transactivation through the transient oxidization of Src homology 2-containing tyrosine phosphatase in endothelin-1 signaling pathway in rat cardiac fibroblasts. Mol Pharmacol. 200 6;69(4): 1347 - 1355 . Chen CH, Cheng TH, Lin H, Shih NL, Chen YL, Chen YS, Reactive oxygen species generation is involved in epidermal growth factor receptor transactivation through the transient oxidization of Src homology 2-containing tyrosine phosphatase in endothelin-1 signaling pathway in rat cardiac fibroblasts. Mol Pharmacol. 2006;69(4):1347-55.","journal-title":"Mol Pharmacol."},{"key":"e_1_3_2_1_30_1","doi-asserted-by":"crossref","unstructured":"Aliper AM Csoka AB Buzdin A Jetka T Roumiantsev S Moskalev A Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells. Aging (Albany NY). 2015;7(1):26-37.  Aliper AM Csoka AB Buzdin A Jetka T Roumiantsev S Moskalev A Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells. Aging (Albany NY). 2015;7(1):26-37.","DOI":"10.18632\/aging.100717"},{"key":"e_1_3_2_1_31_1","doi-asserted-by":"crossref","unstructured":"Ratajczak J Shin DM Wan W Liu R Masternak MM Piotrowska K Higher number of stem cells in the bone marrow of circulating low Igf-1 level Laron dwarf mice\u2013novel view on Igf-1 stem cells and aging. Leukemia. 2011;25(4):729-33.  Ratajczak J Shin DM Wan W Liu R Masternak MM Piotrowska K Higher number of stem cells in the bone marrow of circulating low Igf-1 level Laron dwarf mice\u2013novel view on Igf-1 stem cells and aging. Leukemia. 2011;25(4):729-33.","DOI":"10.1038\/leu.2010.314"},{"key":"e_1_3_2_1_32_1","first-page":"751","volume":"201","author":"Aldini G","unstructured":"Aldini G , Altomare A , Baron G , Vistoli G , Carini M , Borsani L , N- Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radic Res. 201 8;52(7): 751 - 762 . Aldini G, Altomare A, Baron G, Vistoli G, Carini M, Borsani L, N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radic Res. 2018;52(7):751-62.","journal-title":"Free Radic Res."},{"key":"e_1_3_2_1_33_1","doi-asserted-by":"crossref","unstructured":"Kumar P Liu C Hsu JW Chacko S Minard C Jahoor F Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency oxidative stress mitochondrial dysfunction inflammation insulin resistance endothelial dysfunction genotoxicity muscle strength and cognition: Results of a pilot clinical trial. Clin Transl Med. 2021;11(3):e372.  Kumar P Liu C Hsu JW Chacko S Minard C Jahoor F Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency oxidative stress mitochondrial dysfunction inflammation insulin resistance endothelial dysfunction genotoxicity muscle strength and cognition: Results of a pilot clinical trial. Clin Transl Med. 2021;11(3):e372.","DOI":"10.1002\/ctm2.372"},{"key":"e_1_3_2_1_34_1","doi-asserted-by":"crossref","unstructured":"Kumar P Osahon OW Sekhar RV. GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency Oxidative Stress Mitochondrial Dysfunction Abnormalities in Mitophagy and Nutrient Sensing and Genomic Damage. Nutrients. 2022;14(5).  Kumar P Osahon OW Sekhar RV. GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency Oxidative Stress Mitochondrial Dysfunction Abnormalities in Mitophagy and Nutrient Sensing and Genomic Damage. Nutrients. 2022;14(5).","DOI":"10.3390\/nu14051114"}],"event":{"name":"ICCBB 2022: 2022 6th International Conference on Computational Biology and Bioinformatics","acronym":"ICCBB 2022","location":"Bali Island Indonesia"},"container-title":["Proceedings of the 2022 6th International Conference on Computational Biology and Bioinformatics"],"original-title":[],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3589437.3589442","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3589437.3589442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:03:16Z","timestamp":1750291396000},"score":1,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3589437.3589442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,26]]},"references-count":34,"alternative-id":["10.1145\/3589437.3589442","10.1145\/3589437"],"URL":"https:\/\/doi.org\/10.1145\/3589437.3589442","relation":{},"subject":[],"published":{"date-parts":[[2022,12,26]]},"assertion":[{"value":"2023-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}