{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T19:10:01Z","timestamp":1755976201553,"version":"3.44.0"},"publisher-location":"New York, NY, USA","reference-count":15,"publisher":"ACM","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.acm.org\/publications\/policies\/copyright_policy#Background"}],"content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1,12]]},"DOI":"10.1145\/3640900.3640904","type":"proceedings-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T12:04:59Z","timestamp":1709294699000},"page":"44-47","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A dual-function microfluidic chip for single-cell monoclonal antibody affinity screening and functional screening"],"prefix":"10.1145","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2159-9969","authenticated-orcid":false,"given":"Jiyu","family":"Xi","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Beijing Institute of Technology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2608-5802","authenticated-orcid":false,"given":"Zewen","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Beijing Institute of Technology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8183-1374","authenticated-orcid":false,"given":"Zixi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Beijing Institute of Technology, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0818-0882","authenticated-orcid":false,"given":"Zhanhui","family":"Geng","sequence":"additional","affiliation":[{"name":"Institute of System and Engineering, Academy of Military Sciences of People's Liberation Army, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"320","published-online":{"date-parts":[[2024,3]]},"reference":[{"key":"e_1_3_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1136\/mp.53.3.111"},{"key":"e_1_3_2_1_2_1","doi-asserted-by":"crossref","unstructured":"Radocha J van de Donk NWCJ Weisel K. Monoclonal Antibodies and Antibody Drug Conjugates in Multiple Myeloma. Cancers (Basel). 2021 Mar 29;13(7):1571.","DOI":"10.3390\/cancers13071571"},{"key":"e_1_3_2_1_3_1","first-page":"3655","volume":"2021","author":"Goydel RS","unstructured":"Goydel RS, Rader C. Antibody-based cancer therapy. Oncogene. 2021 May;40(21):3655-3664.","journal-title":"Oncogene."},{"key":"e_1_3_2_1_4_1","first-page":"91","volume":"199","author":"Blakey DC.","unstructured":"Blakey DC. Drug targeting with monoclonal antibodies. A review. Acta Oncol. 1992;31(1):91-7.","journal-title":"Acta Oncol."},{"key":"e_1_3_2_1_5_1","first-page":"3","volume":"2019","author":"Glassman PM","unstructured":"Glassman PM, Balthasar JP. Physiologically-based modeling of monoclonal antibody pharmacokinetics in drug discovery and development. Drug Metab Pharmacokinet. 2019 Feb;34(1):3-13.","journal-title":"Drug Metab Pharmacokinet."},{"key":"e_1_3_2_1_6_1","first-page":"37","volume":"201","author":"Kotsovilis S","unstructured":"Kotsovilis S, Andreakos E. Therapeutic human monoclonal antibodies in inflammatory diseases. Methods Mol Biol. 2014; 1060:37-59.","journal-title":"Methods Mol Biol."},{"key":"e_1_3_2_1_7_1","volume":"2021","author":"Ji E","unstructured":"Ji E, Lee S. Antibody-Based Therapeutics for Atherosclerosis and Cardiovascular Diseases. Int J Mol Sci. 2021 May 28;22(11):5770.","journal-title":"Cardiovascular Diseases. Int J Mol Sci."},{"key":"e_1_3_2_1_8_1","first-page":"695","volume":"2004","author":"Casadevall A","unstructured":"Casadevall A, Dadachova E, Pirofski LA. Passive antibody therapy for infectious diseases. Nat Rev Microbiol. 2004 Sep;2(9):695-703.","journal-title":"Nat Rev Microbiol."},{"key":"e_1_3_2_1_9_1","first-page":"1","volume":"2020","author":"Yasunaga M.","unstructured":"Yasunaga M. Antibody therapeutics and immunoregulation in cancer and autoimmune disease. Semin Cancer Biol. 2020 Aug; 64:1-12.","journal-title":"Semin Cancer Biol."},{"key":"e_1_3_2_1_10_1","doi-asserted-by":"crossref","unstructured":"Tafreshi A Cuffe S O'Brien M Rao S Hotta K Leiby MA Lubiniecki GM Shentu Y Rangwala R Brahmer JR; KEYNOTE-024 Investigators. 12. 12. 11. Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer. N Engl J Med. 2016 Nov 10;375(19):1823-1833.","DOI":"10.1056\/NEJMoa1606774"},{"key":"e_1_3_2_1_11_1","volume":"2022","author":"Sun H","unstructured":"Sun H, Hu N, Wang J. Application of microfluidic technology in antibody screening. Biotechnol J. 2022 Aug;17(8): e2100623.","journal-title":"Biotechnol J."},{"key":"e_1_3_2_1_12_1","first-page":"4043","volume":"2020","author":"Zhang W","unstructured":"Zhang W, Li R, Jia F, Hu Z, Li Q, Wei Z. A microfluidic chip for screening high-producing hybridomas at single cell level. Lab Chip. 2020 Nov 7;20(21):4043-4051.","journal-title":"Lab Chip."},{"key":"e_1_3_2_1_13_1","doi-asserted-by":"crossref","unstructured":"Zhang W Li Q Jia F Hu Z Wei Z. A Microfluidic Chip for Screening and Sequencing of Monoclonal Antibody at a Single-Cell Level. Anal Chem. 2021 Jul 27;93(29):10099-10105.","DOI":"10.1021\/acs.analchem.1c00918"},{"key":"e_1_3_2_1_14_1","volume":"1993","author":"Baselga J","unstructured":"Baselga J, Norton L, Masui H, Pandiella A, Coplan K, Miller WH Jr, Mendelsohn J. Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. J Natl Cancer Inst. 1993 Aug 18;85(16):1327-33.","journal-title":"J Natl Cancer Inst."},{"key":"e_1_3_2_1_15_1","doi-asserted-by":"crossref","unstructured":"Medico E Russo M Picco G Cancelliere C Valtorta E Corti G Buscarino M Isella C Lamba S Martinoglio B Veronese S Siena S Sartore-Bianchi A Beccuti M Mottolese M Linnebacher M Cordero F Di Nicolantonio F Bardelli A. The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets. Nat Commun. 2015 Apr 30; 6:7002.","DOI":"10.1038\/ncomms8002"}],"event":{"name":"ICBBB 2024: 2024 14th International Conference on Bioscience, Biochemistry and Bioinformatics","acronym":"ICBBB 2024","location":"Kyoto Japan"},"container-title":["Proceedings of the 2024 14th International Conference on Bioscience, Biochemistry and Bioinformatics"],"original-title":[],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3640900.3640904","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3640900.3640904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T18:36:31Z","timestamp":1755974191000},"score":1,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3640900.3640904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,12]]},"references-count":15,"alternative-id":["10.1145\/3640900.3640904","10.1145\/3640900"],"URL":"https:\/\/doi.org\/10.1145\/3640900.3640904","relation":{},"subject":[],"published":{"date-parts":[[2024,1,12]]},"assertion":[{"value":"2024-03-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}