{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T14:40:05Z","timestamp":1755873605092,"version":"3.44.0"},"publisher-location":"New York, NY, USA","reference-count":24,"publisher":"ACM","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.acm.org\/publications\/policies\/copyright_policy#Background"}],"content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10,20]]},"DOI":"10.1145\/3644116.3644322","type":"proceedings-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T18:38:22Z","timestamp":1712342302000},"page":"1218-1222","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Kinetic parameters, Thermodynamic parameters, and Mechanism of PLpro from SARS-CoV and SARS-CoV-2"],"prefix":"10.1145","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2407-4694","authenticated-orcid":false,"given":"Da","family":"Kang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7827-2944","authenticated-orcid":false,"given":"Kunrong","family":"Mei","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8970-4466","authenticated-orcid":false,"given":"Jianyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"320","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"Forster P. Forster L. Renfrew C. Phylogenetic network analysis of SARS-CoV-2 genomes. PNAS. 2020; 117: 9241-9243","key":"e_1_3_2_1_1_1","DOI":"10.1073\/pnas.2004999117"},{"volume-title":"SARS-CoV-2: The prominent role of non-structural proteins (NSPS) in COVID-19. Indian J Pharm Educ. 2020","author":"Gorla U.S.","unstructured":"Gorla U.S., Rao G.K. SARS-CoV-2: The prominent role of non-structural proteins (NSPS) in COVID-19. Indian J Pharm Educ. 2020; 54(3): S381-389","key":"e_1_3_2_1_2_1"},{"key":"e_1_3_2_1_3_1","volume-title":"Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease. ACS Infect Dis. 2020","author":"Freitas B.T.","year":"2099","unstructured":"Freitas B.T., Durie I.A., Murray J., Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease. ACS Infect Dis. 2020; 6: 2099-2109"},{"doi-asserted-by":"crossref","unstructured":"Yan S.M. Wu G. Spatial and temporal roles of SARS-CoV PLpro\u2013A snapshot. The FASEB Journal. 2021; 35: e21197","key":"e_1_3_2_1_4_1","DOI":"10.1096\/fj.202002271"},{"doi-asserted-by":"crossref","unstructured":"Ratia K. Kilianske A. Baez-Santos Y.M. Structural basis for the ubiquitin-linkage specificity and deISGlating activity of SARS-CoV papain-like protease. PLoS Pathog. 2014; 10 (5): e1004113","key":"e_1_3_2_1_5_1","DOI":"10.1371\/journal.ppat.1004113"},{"doi-asserted-by":"crossref","unstructured":"Swatek K.N. Aumayr M. Pruneda J.N. Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies. PNAS. 2018; 115: 2371-2376","key":"e_1_3_2_1_6_1","DOI":"10.1073\/pnas.1710617115"},{"doi-asserted-by":"crossref","unstructured":"Klemm T. Ebert G. Calleja D.J. Mechanism and inhibition of the papain-like protease PLpro of SARS-CoV-2. EMBO J. 2020; 39: e106275","key":"e_1_3_2_1_7_1","DOI":"10.15252\/embj.2020106275"},{"volume-title":"Papain-like protease protease regulates SARS-CoV-2 viral spread and innate immunity. Nature. 2020","author":"Shin D.","unstructured":"Shin D., Mukherjee R., Papain-like protease protease regulates SARS-CoV-2 viral spread and innate immunity. Nature. 2020; Vol 587: 657-662","key":"e_1_3_2_1_8_1"},{"volume-title":"Crystal structure of SARS-CoV-2 papain-like protease. Acta Pharm Sin B. 2021","author":"Gao X.P.","unstructured":"Gao X.P., Qin B., Chen P., Crystal structure of SARS-CoV-2 papain-like protease. Acta Pharm Sin B. 2021; 11(1): 237-245","key":"e_1_3_2_1_9_1"},{"doi-asserted-by":"crossref","unstructured":"Ma C.L. Sacco M.D. Xia Z.L. Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and a flipGFP-based reporter assay. ACS Cent. Sci. 2021; 7: 1245-1260","key":"e_1_3_2_1_10_1","DOI":"10.1021\/acscentsci.1c00519"},{"doi-asserted-by":"crossref","unstructured":"Rut W. Lv ZY. Zmudzinske M. Activity profiling and crystal structures of inhibitor bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design. Sci. Adv. 2020; 6: eabd4596","key":"e_1_3_2_1_11_1","DOI":"10.1126\/sciadv.abd4596"},{"doi-asserted-by":"crossref","unstructured":"Thurakkal L. Singh S. Roy R. An in-silico study on selected organosulfur compounds as potential drugs for SARS-CoV-2 infection via binding multiple drug targets. Chem Phys Lett. 2021; 763: 138193","key":"e_1_3_2_1_12_1","DOI":"10.1016\/j.cplett.2020.138193"},{"doi-asserted-by":"crossref","unstructured":"Naidoo D. Kar P. Roy A. Structural insight into the binding of cyanovirin-N with the spike glycoprotein Mpro and PLpro of SARS-CoV-2: Protein-protein interactions dynamics simulations and free energy calculations. Molecules. 2021; 26: 5114","key":"e_1_3_2_1_13_1","DOI":"10.3390\/molecules26175114"},{"doi-asserted-by":"crossref","unstructured":"Sanachai K. Mahalapbutr P. Lee V.S. In silico elucidation of potent inhibitors and rational drug design against SARS-CoV-2 papain-like protease. J. Phys. Chem. B. 2021; 125: 13644-13656","key":"e_1_3_2_1_14_1","DOI":"10.1021\/acs.jpcb.1c07060"},{"doi-asserted-by":"crossref","unstructured":"Bhowmick S. AlFaris N.A. ALTamimi J.Z. Identification of bio-active food compounds as potential SARS-CoV-2 PLpro inhibitors-modulators via negative image-based screening and computational simulations. Comput Biol Med. 2022; 145: 105474","key":"e_1_3_2_1_15_1","DOI":"10.1016\/j.compbiomed.2022.105474"},{"doi-asserted-by":"crossref","unstructured":"Singh E. Jha R.K. Khan R.J. Kumar A. A computational essential dynamics approach to investigate structural influences of ligand binding on papain like protease from SARS-CoV-2. Comput Biol Chem. 2022; 99: 107721","key":"e_1_3_2_1_16_1","DOI":"10.1016\/j.compbiolchem.2022.107721"},{"doi-asserted-by":"crossref","unstructured":"Qayed W.S. Ferreira R.S. Silva J.R.A. Insilico study towards repositioning of FDA-approved drug candidates for anticoronaviral therapy: molecular docking molecular dynamics and binding free energy calculations. Molecules. 2022; 27: 5988","key":"e_1_3_2_1_17_1","DOI":"10.3390\/molecules27185988"},{"volume-title":"Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease. Acta Cryst. 2014","author":"Chou C.Y.","unstructured":"Chou C.Y., Lai H.Y., Chen H.Y., Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease. Acta Cryst. 2014; 70: 572-581","key":"e_1_3_2_1_18_1"},{"volume-title":"Structural basis for catalysis and ubiquitin recognition by the Severe acute respiratory syndrome coronavirus papain-like protease. Acta Cryst. 2014","author":"Chou C.Y.","unstructured":"Chou C.Y., Lai H.Y., Chen H.Y., Structural basis for catalysis and ubiquitin recognition by the Severe acute respiratory syndrome coronavirus papain-like protease. Acta Cryst. 2014; D70: 572-581","key":"e_1_3_2_1_19_1"},{"doi-asserted-by":"crossref","unstructured":"Patchaett S. Lv Z.Y. Rut W. A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease. Cell Rep. 2021; 26: 10754.","key":"e_1_3_2_1_20_1","DOI":"10.1016\/j.celrep.2021.109754"},{"key":"e_1_3_2_1_21_1","first-page":"16119","volume-title":"Proc. Natl. Acad. Sci. 2008; 105 (42)","author":"Ratia K.","unstructured":"Ratia K., Pegan S., Takayama J., A noncovalent class of papain-like protease\/deubiquitinase inhibition blocks SARS virus replication. Proc. Natl. Acad. Sci. 2008; 105 (42): 16119-16124"},{"doi-asserted-by":"crossref","unstructured":"Lee H. Lei H. Santarsiero B.D. Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV. ACS Chem. Biol. 2015; 10: 1456-1465.","key":"e_1_3_2_1_22_1","DOI":"10.1021\/cb500917m"},{"doi-asserted-by":"crossref","unstructured":"Osipiuk J. Azizi S.-A. Dvorkin S. Structure of Papain-like Protease from SARS-CoV-2 and its Complexes with Non-covalent Inhibitors. Nat. Commun. 2021; 12 (1) 743","key":"e_1_3_2_1_23_1","DOI":"10.1038\/s41467-021-21060-3"},{"doi-asserted-by":"publisher","key":"e_1_3_2_1_24_1","DOI":"10.1016\/j.chembiol.2021.04.020"}],"event":{"acronym":"ISAIMS 2023","name":"ISAIMS 2023: 2023 4th International Symposium on Artificial Intelligence for Medicine Science","location":"Chengdu China"},"container-title":["Proceedings of the 2023 4th International Symposium on Artificial Intelligence for Medicine Science"],"original-title":[],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3644116.3644322","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3644116.3644322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T14:16:13Z","timestamp":1755872173000},"score":1,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3644116.3644322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,20]]},"references-count":24,"alternative-id":["10.1145\/3644116.3644322","10.1145\/3644116"],"URL":"https:\/\/doi.org\/10.1145\/3644116.3644322","relation":{},"subject":[],"published":{"date-parts":[[2023,10,20]]},"assertion":[{"value":"2024-04-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}