{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T05:03:19Z","timestamp":1750309399681,"version":"3.41.0"},"publisher-location":"New York, NY, USA","reference-count":31,"publisher":"ACM","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.acm.org\/publications\/policies\/copyright_policy#Background"}],"content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5,24]]},"DOI":"10.1145\/3674658.3674668","type":"proceedings-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T22:07:19Z","timestamp":1731967639000},"page":"53-57","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["PAX9 Overexpression in Lung Adenocarcinoma and Promotes Cancer Progression"],"prefix":"10.1145","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9568-3128","authenticated-orcid":false,"given":"Dandan","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4962-8472","authenticated-orcid":false,"given":"Yuxin","family":"Du","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4250-1674","authenticated-orcid":false,"given":"Wenhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4651-9972","authenticated-orcid":false,"given":"Xiaoshuai","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1872-108X","authenticated-orcid":false,"given":"Changyun","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3574-8946","authenticated-orcid":false,"given":"Fengwu","family":"Qiu","sequence":"additional","affiliation":[{"name":"Wuhan Blood Center, Wuhan, Hubei, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4380-735X","authenticated-orcid":false,"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1658-3616","authenticated-orcid":false,"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, Hubei, China"}]}],"member":"320","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"e_1_3_3_1_1_2","first-page":"7","volume":"2022","author":"Siegel RL","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A: Cancer statistics, 2022. CA Cancer J Clin 2022, 72(1):7-33.","journal-title":"CA Cancer J Clin"},{"key":"e_1_3_3_1_2_2","first-page":"7","volume":"2020","author":"Siegel RL","unstructured":"Siegel RL, Miller KD, Jemal A: Cancer statistics, 2020. CA Cancer J Clin 2020, 70(1):7-30.","journal-title":"CA Cancer J Clin"},{"key":"e_1_3_3_1_3_2","first-page":"446","volume":"2018","author":"Herbst RS","unstructured":"Herbst RS, Morgensztern D, Boshoff C: The biology and management of non-small cell lung cancer. Nature 2018, 553(7689):446-454.","journal-title":"Nature"},{"key":"e_1_3_3_1_4_2","first-page":"7686","volume":"2020","author":"Xu S","unstructured":"Xu S, Wang Y, Ren F, Li X, Ren D, Dong M, Chen G, Song Z, Chen J: Impact of genetic alterations on outcomes of patients with stage I nonsmall cell lung cancer: An analysis of the cancer genome atlas data. Cancer Med 2020, 9(20):7686-7694.","journal-title":"Cancer Med"},{"key":"e_1_3_3_1_5_2","first-page":"584","volume-title":"Mayo Clin Proc","author":"Molina JR","year":"2008","unstructured":"Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA: Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc 2008, 83(5):584-594."},{"key":"e_1_3_3_1_6_2","first-page":"288","volume":"2016","author":"Zappa C","unstructured":"Zappa C, Mousa SA: Non-small cell lung cancer: current treatment and future advances. Transl Lung Cancer Res 2016, 5(3):288-300.","journal-title":"Transl Lung Cancer Res"},{"key":"e_1_3_3_1_7_2","volume-title":"Dela Cruz CS: Lung Cancer 2020: Epidemiology, Etiology, and Prevention. Clin Chest Med","author":"Bade BC","year":"2020","unstructured":"Bade BC, Dela Cruz CS: Lung Cancer 2020: Epidemiology, Etiology, and Prevention. Clin Chest Med 2020, 41(1):1-24."},{"key":"e_1_3_3_1_8_2","volume":"2014","author":"Zonderman AB","unstructured":"Zonderman AB, Ejiogu N, Norbeck J, Evans MK: The influence of health disparities on targeting cancer prevention efforts. Am J Prev Med 2014, 46(3 Suppl 1):S87-97.","journal-title":"Am J Prev Med"},{"key":"e_1_3_3_1_9_2","volume":"2019","author":"Lee SS","unstructured":"Lee SS, Cheah YK: The Interplay between MicroRNAs and Cellular Components of Tumour Microenvironment (TME) on Non-Small-Cell Lung Cancer (NSCLC) Progression. J Immunol Res 2019, 2019:3046379.","journal-title":"Progression. J Immunol Res"},{"key":"e_1_3_3_1_10_2","volume":"2022","author":"Chen X","unstructured":"Chen X, Li Y, Paiboonrungruang C, Li Y, Peters H, Kist R, Xiong Z: PAX9 in Cancer Development. Int J Mol Sci 2022, 23(10).","journal-title":"Cancer Development. Int J Mol Sci"},{"key":"e_1_3_3_1_11_2","first-page":"2735","volume":"1998","author":"Peters H","unstructured":"Peters H, Neub\u00fcser A, Kratochwil K, Balling R: Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes Dev 1998, 12(17):2735-2747.","journal-title":"Genes Dev"},{"key":"e_1_3_3_1_12_2","first-page":"1313","volume":"2004","author":"Jonker L","unstructured":"Jonker L, Kist R, Aw A, Wappler I, Peters H: Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium. Mech Dev 2004, 121(11):1313-1322.","journal-title":"Mech Dev"},{"key":"e_1_3_3_1_13_2","volume-title":"Peters H: The formation of endoderm-derived taste sensory organs requires a Pax9-dependent expansion of embryonic taste bud progenitor cells. PLoS Genet","author":"Kist R","year":"2014","unstructured":"Kist R, Watson M, Crosier M, Robinson M, Fuchs J, Reichelt J, Peters H: The formation of endoderm-derived taste sensory organs requires a Pax9-dependent expansion of embryonic taste bud progenitor cells. PLoS Genet 2014, 10(10):e1004709."},{"key":"e_1_3_3_1_14_2","first-page":"438","volume":"2010","author":"Nakatomi M","unstructured":"Nakatomi M, Wang XP, Key D, Lund JJ, Turbe-Doan A, Kist R, Aw A, Chen Y, Maas RL, Peters H: Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis. Dev Biol 2010, 340(2):438-449.","journal-title":"Dev Biol"},{"key":"e_1_3_3_1_15_2","first-page":"187","volume":"2017","author":"Sivakamasundari V","unstructured":"Sivakamasundari V, Kraus P, Sun W, Hu X, Lim SL, Prabhakar S, Lufkin T: A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development. Biol Open 2017, 6(2):187-199.","journal-title":"Biol Open"},{"key":"e_1_3_3_1_16_2","volume-title":"Phillips HM et al: Msx1 haploinsufficiency modifies the Pax9-deficient cardiovascular phenotype. BMC Dev Biol","author":"Khasawneh RR","year":"2021","unstructured":"Khasawneh RR, Kist R, Queen R, Hussain R, Coxhead J, Schneider JE, Mohun TJ, Zaffran S, Peters H, Phillips HM et al: Msx1 haploinsufficiency modifies the Pax9-deficient cardiovascular phenotype. BMC Dev Biol 2021, 21(1):14."},{"key":"e_1_3_3_1_17_2","doi-asserted-by":"crossref","unstructured":"Phillips HM Stothard CA Shaikh Qureshi WM Kousa AI Briones-Leon JA Khasawneh RR O'Loughlin C Sanders R Mazzotta S Dodds R et al: Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis. Development 2019 146(18).","DOI":"10.1242\/dev.177618"},{"key":"e_1_3_3_1_18_2","first-page":"16663","volume":"2007","author":"Kendall J","unstructured":"Kendall J, Liu Q, Bakleh A, Krasnitz A, Nguyen KC, Lakshmi B, Gerald WL, Powers S, Mu D: Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer. Proc Natl Acad Sci U S A 2007, 104(42):16663-16668.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"e_1_3_3_1_19_2","first-page":"4696","volume":"2021","author":"Zhao Z","unstructured":"Zhao Z, Szczepanski AP, Tsuboyama N, Abdala-Valencia H, Goo YA, Singer BD, Bartom ET, Yue F, Wang L: PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer. Cancer Res 2021, 81(18):4696-4708.","journal-title":"Cancer. Cancer Res"},{"key":"e_1_3_3_1_20_2","first-page":"22687","volume":"2019","author":"Bai G","unstructured":"Bai G, Song J, Yuan Y, Chen Z, Tian Y, Yin X, Niu Y, Liu J: Systematic analysis of differentially methylated expressed genes and site-specific methylation as potential prognostic markers in head and neck cancer. J Cell Physiol 2019, 234(12):22687-22702.","journal-title":"J Cell Physiol"},{"key":"e_1_3_3_1_21_2","first-page":"806","volume":"2017","author":"Tan B","unstructured":"Tan B, Wang J, Song Q, Wang N, Jia Y, Wang C, Yao B, Liu Z, Zhang X, Cheng Y: Prognostic value of PAX9 in patients with esophageal squamous cell carcinoma and its prediction value to radiation sensitivity. Mol Med Rep 2017, 16(1):806-816.","journal-title":"Mol Med Rep"},{"key":"e_1_3_3_1_22_2","volume-title":"Onaitis MW et al: Transcriptional signature primes human oral mucosa for rapid wound healing. Sci Transl Med","author":"Iglesias-Bartolome R","year":"2018","unstructured":"Iglesias-Bartolome R, Uchiyama A, Molinolo AA, Abusleme L, Brooks SR, Callejas-Valera JL, Edwards D, Doci C, Asselin-Labat ML, Onaitis MW et al: Transcriptional signature primes human oral mucosa for rapid wound healing. Sci Transl Med 2018, 10(451)."},{"key":"e_1_3_3_1_23_2","first-page":"293","volume":"2002","author":"Gerber JK","unstructured":"Gerber JK, Richter T, Kremmer E, Adamski J, H\u00f6fler H, Balling R, Peters H: Progressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus. J Pathol 2002, 197(3):293-297.","journal-title":"J Pathol"},{"key":"e_1_3_3_1_24_2","volume-title":"Hui CC et al: Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development. Mech Dev","author":"McGlinn E","year":"2005","unstructured":"McGlinn E, van Bueren KL, Fiorenza S, Mo R, Poh AM, Forrest A, Soares MB, Bonaldo Mde F, Grimmond S, Hui CC et al: Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development. Mech Dev 2005, 122(11):1218-1233."},{"key":"e_1_3_3_1_25_2","first-page":"2560","volume":"2017","author":"Feng J","unstructured":"Feng J, Jing J, Li J, Zhao H, Punj V, Zhang T, Xu J, Chai Y: BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice. Development 2017, 144(14):2560-2569.","journal-title":"Development"},{"key":"e_1_3_3_1_26_2","first-page":"246","volume":"2020","author":"Sweat YY","unstructured":"Sweat YY, Sweat M, Mansaray M, Cao H, Eliason S, Adeyemo WL, Gowans LJJ, Eshete MA, Anand D, Chalkley C et al: Six2 regulates Pax9 expression, palatogenesis and craniofacial bone formation. Dev Biol 2020, 458(2):246-256.","journal-title":"Dev Biol"},{"key":"e_1_3_3_1_27_2","first-page":"548","volume":"2001","author":"Mandler M","unstructured":"Mandler M, Neub\u00fcser A: FGF signaling is necessary for the specification of the odontogenic mesenchyme. Dev Biol 2001, 240(2):548-559.","journal-title":"Dev Biol"},{"key":"e_1_3_3_1_28_2","volume-title":"Khokha MK","author":"Farley-Barnes KI","year":"2020","unstructured":"Farley-Barnes KI, Deniz E, Overton MM, Khokha MK, Baserga SJ: Paired Box 9 (PAX9), the RNA polymerase II transcription factor, regulates human ribosome biogenesis and craniofacial development. PLoS Genet 2020, 16(8):e1008967."},{"key":"e_1_3_3_1_29_2","volume-title":"Volarevi\u0107 S: Corrigendum: Ribosome biogenesis in cancer: new players and therapeutic avenues. Nat Rev Cancer","author":"Pelletier J","year":"2018","unstructured":"Pelletier J, Thomas G, Volarevi\u0107 S: Corrigendum: Ribosome biogenesis in cancer: new players and therapeutic avenues. Nat Rev Cancer 2018, 18(2):134."},{"key":"e_1_3_3_1_30_2","volume-title":"De Castro J et al: Transcriptional epigenetic regulation of Fkbp1\/Pax9 genes is associated with impaired sensitivity to platinum treatment in ovarian cancer. Clin Epigenetics","author":"Soto JA","year":"2021","unstructured":"Soto JA, Rodr\u00edguez-Antol\u00edn C, Vera O, Pern\u00eda O, Esteban-Rodr\u00edguez I, Dolores Diestro M, Benitez J, S\u00e1nchez-Cabo F, Alvarez R, De Castro J et al: Transcriptional epigenetic regulation of Fkbp1\/Pax9 genes is associated with impaired sensitivity to platinum treatment in ovarian cancer. Clin Epigenetics 2021, 13(1):167."},{"key":"e_1_3_3_1_31_2","first-page":"7939","volume":"2006","author":"Rauch T","unstructured":"Rauch T, Li H, Wu X, Pfeifer GP: MIRA-assisted microarray analysis, a new technology for the determination of DNA methylation patterns, identifies frequent methylation of homeodomain-containing genes in lung cancer cells. Cancer Res 2006, 66(16):7939-7947.","journal-title":"Cancer Res"}],"event":{"name":"ICBBT 2024: 2024 16th International Conference on Bioinformatics and Biomedical Technology","acronym":"ICBBT 2024","location":"Chongqing China"},"container-title":["Proceedings of the 2024 16th International Conference on Bioinformatics and Biomedical Technology"],"original-title":[],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3674658.3674668","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3674658.3674668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:57:50Z","timestamp":1750294670000},"score":1,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3674658.3674668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,24]]},"references-count":31,"alternative-id":["10.1145\/3674658.3674668","10.1145\/3674658"],"URL":"https:\/\/doi.org\/10.1145\/3674658.3674668","relation":{},"subject":[],"published":{"date-parts":[[2024,5,24]]},"assertion":[{"value":"2024-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}