{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T05:04:33Z","timestamp":1750309473266,"version":"3.41.0"},"publisher-location":"New York, NY, USA","reference-count":14,"publisher":"ACM","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.acm.org\/publications\/policies\/copyright_policy#Background"}],"content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,8,13]]},"DOI":"10.1145\/3706890.3707017","type":"proceedings-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T13:37:20Z","timestamp":1736775440000},"page":"741-746","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimization of anti-LAG-3 antibody: A comprehensive computer study"],"prefix":"10.1145","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3058-4205","authenticated-orcid":false,"given":"Liqing","family":"Wu","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, China"}]}],"member":"320","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"e_1_3_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510665"},{"key":"e_1_3_3_1_2_2","volume-title":"Immune-Related Adverse Events Associated with Immune Checkpoint Blockade [J]. N Engl J Med","author":"Postow M. A.","year":"2018","unstructured":"bib id=\"bib2\"><number>[2]Postow M. A., Sidlow R., Hellmann M. D. Immune-Related Adverse Events Associated with Immune Checkpoint Blockade [J]. N Engl J Med, 2018, 378(2): 158-168."},{"key":"e_1_3_3_1_3_2","first-page":"558","volume-title":"Nature","author":"Powles T.","year":"2014","unstructured":"bib id=\"bib3\"><number>[3]Powles T., Eder J. P., Fine G. D., et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer [J]. Nature, 2014, 515(7528): 558-562."},{"key":"e_1_3_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.05.001"},{"key":"e_1_3_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010075"},{"key":"e_1_3_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001014"},{"key":"e_1_3_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxs098"},{"key":"e_1_3_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0217-9"},{"key":"e_1_3_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.11.5744"},{"key":"e_1_3_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2018.02.003"},{"key":"e_1_3_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2023.07.013"},{"key":"e_1_3_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2015.09.014"},{"key":"e_1_3_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2003.10.069"},{"key":"e_1_3_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.24230"}],"event":{"name":"ISAIMS 2024: 2024 5th International Symposium on Artificial Intelligence for Medicine Science","acronym":"ISAIMS 2024","location":"Amsterdam Netherlands"},"container-title":["Proceedings of the 2024 5th International Symposium on Artificial Intelligence for Medicine Science"],"original-title":[],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3706890.3707017","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3706890.3707017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T01:17:20Z","timestamp":1750295840000},"score":1,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3706890.3707017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,13]]},"references-count":14,"alternative-id":["10.1145\/3706890.3707017","10.1145\/3706890"],"URL":"https:\/\/doi.org\/10.1145\/3706890.3707017","relation":{},"subject":[],"published":{"date-parts":[[2024,8,13]]},"assertion":[{"value":"2025-01-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}