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The software can be easily extended to incorporate new tests and games. We present a proof of concept demonstrating the functionality of the software and its applicability in individuals with impaired binocularity. We evaluate a stereoacuity test in VR based on disparity detection using contoured objects by comparing its results to those obtained by standard clinical tests, i.e., TNO, Randot, and Titmus, for 7 amblyopes and 6 healthy controls. We evaluate the applicability of a new VR-based suppression test in 10 amblyopes and 6 healthy individuals. For the latter, we exploit the effects of short-term monocular deprivation, which induce a change of ocular dominance. Finally, we outline technical limitations and discuss potential applications.<\/jats:p>","DOI":"10.1145\/3733833","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T12:02:56Z","timestamp":1746619376000},"page":"1-22","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["An Extensible Open Source Software Designed for Virtual Reality-Based Testing and Treatment of Vision Disorders"],"prefix":"10.1145","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3070-8475","authenticated-orcid":false,"given":"Johann","family":"Schneider","sequence":"first","affiliation":[{"name":"Frankfurt Institute for Advanced Studies, Frankfurt am Main, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1303-9990","authenticated-orcid":false,"given":"Yu Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Frankfurt Institute for Advanced Studies, Frankfurt am Main, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6572-1138","authenticated-orcid":false,"given":"Maria","family":"Fronius","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Child Vision Research Unit, Goethe University, Frankfurt am Main, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0844-3626","authenticated-orcid":false,"given":"Juliane","family":"Tittes","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Child Vision Research Unit, Goethe University, Frankfurt am Main, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8166-2441","authenticated-orcid":false,"given":"Jochen","family":"Triesch","sequence":"additional","affiliation":[{"name":"Frankfurt Institute for Advanced Studies, Frankfurt am Main, Germany"}]}],"member":"320","published-online":{"date-parts":[[2025,7,12]]},"reference":[{"key":"e_1_3_1_2_2","unstructured":"FOVE Co. 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