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In a 2\u2009\u00d7\u20094 factorial between-participants experiment (N\u2009=\u2009266), participants were randomized to virtual health assistants varying in visual fidelity and voice modality. Structural equation modeling revealed that voice naturalness had a strong positive effect on perceived realism, which in turn significantly predicted screening intentions. Visual fidelity also contributed directly to perceived realism, although to a lesser extent. 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