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To assess its potential for tracking ALS progression, we conducted a cross-sectional in-clinic study with 27 ALS patients and a longitudinal at-home study with 11 ALS patients over 21\u2009weeks. Self-reported ALSFRS-R scores showed a strong correlation with in-clinic assessments. High-level physical activity features, such as time spent indoors, were associated with gross motor function. Speech analysis differentiated patients with and without bulbar dysfunction and correlated with respiratory parameters. Home spirometry aligned with clinical respiratory measures. These findings support the feasibility of using HomeSenseALS for remote, multimodal monitoring of ALS progression, potentially reducing patient burden while enabling more continuous and granular tracking of functional decline.<\/jats:p>","DOI":"10.1145\/3757930","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:45:16Z","timestamp":1755794716000},"page":"1-26","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["HomeSenseALS: A Mobile Sensing and Self-Monitoring System to Monitor Patients with ALS in Everyday Life"],"prefix":"10.1145","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8481-6079","authenticated-orcid":false,"given":"Duarte","family":"Folgado","sequence":"first","affiliation":[{"name":"Fraunhofer Portugal AICOS, Porto, Portugal and Comprehensive Health Research Centre (CHRC), Porto, 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