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Simulated environments offer a partial solution but are typically constrained by rule-based scenarios and still depend heavily on human input to guide interactions and interpret results. Recent advances in large language models (LLMs) have introduced the possibility of generative agents that can simulate realistic human behavior, reasoning, and social dynamics. However, their effectiveness in modeling human-assistant interactions remains largely unexplored. To address this gap, we present a generative agent-based simulation platform designed to simulate human-assistant interactions. We identify ten prior studies on assistant agents that span different aspects of interaction design and replicate these studies using our simulation platform. Our results show that fully simulated experiments using generative agents can approximate key aspects of human-assistant interactions. Based on these simulations, we are able to replicate the core conclusions of the original studies. Our work provides a scalable and cost-effective approach for studying assistant agent design without requiring live human subjects. Additional resources and project materials are available at https:\/\/dash-gidea.github.io\/.<\/jats:p>","DOI":"10.1145\/3770661","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T19:42:32Z","timestamp":1764704552000},"page":"1-46","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Design and Evaluation of Generative Agent-based Platform for Human-Assistant Interaction Research: A Tale of 10 User Studies"],"prefix":"10.1145","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1375-3645","authenticated-orcid":false,"given":"Ziyi","family":"Xuan","sequence":"first","affiliation":[{"name":"Department of Computer Science and Engineering, Lehigh University, Bethlehem, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5535-7054","authenticated-orcid":false,"given":"Yiwen","family":"Wu","sequence":"additional","affiliation":[{"name":"Lehigh University, Bethlehem, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5930-3899","authenticated-orcid":false,"given":"Xuhai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, Columbia University, New York City, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0705-6990","authenticated-orcid":false,"given":"Vinod","family":"Namboodiri","sequence":"additional","affiliation":[{"name":"Lehigh University, Bethlehem, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0117-0621","authenticated-orcid":false,"given":"Mooi Choo","family":"Chuah","sequence":"additional","affiliation":[{"name":"Lehigh University, Bethlehem, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1627-5503","authenticated-orcid":false,"given":"Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Lehigh University, Bethlehem, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"320","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1145\/3448090"},{"key":"e_1_2_1_2_1","unstructured":"Amazon. 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