{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:25:00Z","timestamp":1768454700999,"version":"3.49.0"},"publisher-location":"New York, NY, USA","reference-count":76,"publisher":"ACM","content-domain":{"domain":["dl.acm.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10,24]]},"DOI":"10.1145\/3777577.3777696","type":"proceedings-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T18:07:00Z","timestamp":1768414020000},"page":"733-740","update-policy":"https:\/\/doi.org\/10.1145\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrating Genomics, Proteomics, and Metabolomics to Identify Precision Targets in Impaired Fracture Healing"],"prefix":"10.1145","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9187-5748","authenticated-orcid":false,"given":"Jiaqi","family":"He","sequence":"first","affiliation":[{"name":"Henan University of Technology, Zhengzhou, Henan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"320","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_3_3_1_1_2","first-page":"329","volume":"202","author":"Gomez-Barrena E.","unstructured":"Gomez-Barrena, E. and C. Ehrnthaller, Long bone uninfected non-union: grafting techniques. EFORT Open Rev, 2024. 9(5): p. 329-338.","journal-title":"EFORT Open Rev"},{"key":"e_1_3_3_1_2_2","volume":"201","author":"Ekegren C.L.","unstructured":"Ekegren, C.L., et al., Incidence, Costs and Predictors of Non-Union, Delayed Union and Mal-Union Following Long Bone Fracture. Int J Environ Res Public Health, 2018. 15(12).","journal-title":"Int J Environ Res Public Health"},{"key":"e_1_3_3_1_3_2","first-page":"533","volume":"202","author":"Yoon B.H.","unstructured":"Yoon, B.H., M. Kim, and Y.H. Roh, Does the Nonunion Rate of Atypical Femoral Fractures Differ According to Fracture Site?: A Meta-Analysis. Clin Orthop Surg, 2024. 16(4): p. 533-541.","journal-title":"Meta-Analysis. Clin Orthop Surg"},{"key":"e_1_3_3_1_4_2","volume":"202","author":"Bowers K.M.","unstructured":"Bowers, K.M. and D.E. Anderson, Delayed Union and Nonunion: Current Concepts, Prevention, and Correction: A Review. Bioengineering (Basel), 2024. 11(6).","journal-title":"Review. Bioengineering (Basel)"},{"key":"e_1_3_3_1_5_2","first-page":"3200","volume":"202","author":"Wittauer M.","unstructured":"Wittauer, M., et al., Definition of long-bone nonunion: A scoping review of prospective clinical trials to evaluate current practice. Injury, 2021. 52(11): p. 3200-3205.","journal-title":"Injury"},{"key":"e_1_3_3_1_6_2","first-page":"516","volume":"202","author":"Jensen S.S.","unstructured":"Jensen, S.S., et al., Risk factors for nonunion following surgically managed, traumatic, diaphyseal fractures: a systematic review and meta-analysis. EFORT Open Rev, 2022. 7(7): p. 516-525.","journal-title":"EFORT Open Rev"},{"key":"e_1_3_3_1_7_2","volume-title":"Bioengineering","author":"Saul D.","year":"2023","unstructured":"Saul, D., et al., Bone Healing Gone Wrong: Pathological Fracture Healing and Non-Unions-Overview of Basic and Clinical Aspects and Systematic Review of Risk Factors. Bioengineering (Basel), 2023. 10(1)."},{"key":"e_1_3_3_1_8_2","volume":"202","author":"Rodriguez-Merchan E.C.","unstructured":"Rodriguez-Merchan, E.C., A Review of Recent Developments in the Molecular Mechanisms of Bone Healing. Int J Mol Sci, 2021. 22(2).","journal-title":"Bone Healing. Int J Mol Sci"},{"key":"e_1_3_3_1_9_2","first-page":"1060","volume":"202","author":"Avin K.G.","unstructured":"Avin, K.G., et al., Single-cell RNAseq provides insight into altered immune cell populations in human fracture nonunions. J Orthop Res, 2023. 41(5): p. 1060-1069.","journal-title":"J Orthop Res"},{"key":"e_1_3_3_1_10_2","first-page":"117091","volume-title":"Bone","author":"Salichos L.","year":"2024","unstructured":"Salichos, L., et al., Human nonunion tissues display differential gene expression in comparison to physiological fracture callus. Bone, 2024. 183: p. 117091."},{"key":"e_1_3_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.176802"},{"key":"e_1_3_3_1_12_2","volume-title":"Bioengineering","author":"Grgurevic L.","year":"2024","unstructured":"Grgurevic, L., et al., Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions? Bioengineering (Basel), 2024. 11(11)."},{"key":"e_1_3_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.5846"},{"key":"e_1_3_3_1_14_2","first-page":"1023650","volume-title":"Front Vet Sci","author":"Bow A.J.","year":"2022","unstructured":"Bow, A.J., et al., Temporal metabolic profiling of bone healing in a caprine tibia segmental defect model. Front Vet Sci, 2022. 9: p. 1023650."},{"key":"e_1_3_3_1_15_2","first-page":"780626","volume-title":"Front Chem","author":"Groven R.V.M.","year":"2021","unstructured":"Groven, R.V.M., et al., Lipid Analysis of Fracture Hematoma With MALDI-MSI: Specific Lipids are Associated with Bone Fracture Healing Over Time. Front Chem, 2021. 9: p. 780626."},{"key":"e_1_3_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkaf019"},{"key":"e_1_3_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-08316-0"},{"key":"e_1_3_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2024.101780"},{"key":"e_1_3_3_1_19_2","first-page":"113","volume":"202","author":"Hadjiargyrou M.","unstructured":"Hadjiargyrou, M., L. Salichos, and P. Kloen, Identification of the miRNAome in human fracture callus and nonunion tissues. J Orthop Translat, 2023. 39: p. 113-123.","journal-title":"J Orthop Translat"},{"key":"e_1_3_3_1_20_2","first-page":"601","volume":"202","author":"Panteli M.","unstructured":"Panteli, M., et al., Biological and molecular profile of fracture non-union tissue: A systematic review and an update on current insights. J Cell Mol Med, 2022. 26(3): p. 601-623.","journal-title":"J Cell Mol Med"},{"key":"e_1_3_3_1_21_2","first-page":"279","volume-title":"Angiogenesis","author":"Menger M.M.","year":"2022","unstructured":"Menger, M.M., et al., The vascularization paradox of non-union formation. Angiogenesis, 2022. 25(3): p. 279-290."},{"key":"e_1_3_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-024-00347-3"},{"key":"e_1_3_3_1_23_2","volume-title":"Single-Cell RNA Sequencing Reveals B Cells Are Important Regulators in Fracture Healing. Front Endocrinol (Lausanne)","author":"Zhang H.","year":"2021","unstructured":"Zhang, H., et al., Single-Cell RNA Sequencing Reveals B Cells Are Important Regulators in Fracture Healing. Front Endocrinol (Lausanne), 2021. 12: p. 666140."},{"key":"e_1_3_3_1_24_2","first-page":"1476009","volume-title":"Front Immunol","author":"Voss J.O.","year":"2024","unstructured":"Voss, J.O., et al., Prognostic implications of a CD8(+) T(EMRA) to CD4(+)T(reg) imbalance in mandibular fracture healing: a prospective analysis of immune profiles. Front Immunol, 2024. 15: p. 1476009."},{"key":"e_1_3_3_1_25_2","first-page":"330","volume":"202","author":"Molitoris K.H.","unstructured":"Molitoris, K.H., M. Huang, and G.S. Baht, Osteoimmunology of Fracture Healing. Curr Osteoporos Rep, 2024. 22(3): p. 330-339.","journal-title":"Fracture Healing. Curr Osteoporos Rep"},{"key":"e_1_3_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218395"},{"key":"e_1_3_3_1_27_2","first-page":"115758","volume-title":"Bone","author":"Komatsu D.E.","year":"2021","unstructured":"Komatsu, D.E., E. Duque, and M. Hadjiargyrou, MicroRNAs and fracture healing: Pre-clinical studies. Bone, 2021. 143: p. 115758."},{"key":"e_1_3_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.144766"},{"key":"e_1_3_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193673"},{"key":"e_1_3_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-12-44"},{"key":"e_1_3_3_1_31_2","first-page":"23","volume":"201","author":"McCoy T.H.","unstructured":"McCoy, T.H., Jr., et al., Genomewide Association Study of Fracture Nonunion Using Electronic Health Records. JBMR Plus, 2019. 3(1): p. 23-28.","journal-title":"JBMR Plus"},{"key":"e_1_3_3_1_32_2","first-page":"569","volume":"202","author":"Sadat-Ali M.","unstructured":"Sadat-Ali, M., et al., Genetic Influence of Fracture Nonunion (FNU): A Systematic Review. Pharmgenomics Pers Med, 2023. 16: p. 569-575.","journal-title":"Pharmgenomics Pers Med"},{"key":"e_1_3_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.92519.3.sa3"},{"key":"e_1_3_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-023-00288-1"},{"key":"e_1_3_3_1_35_2","volume-title":"Cells","author":"Jiang W.","year":"2024","unstructured":"Jiang, W., et al., Unique Spatial Transcriptomic Profiling of the Murine Femoral Fracture Callus: A Preliminary Report. Cells, 2024. 13(6)."},{"key":"e_1_3_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.89822"},{"key":"e_1_3_3_1_37_2","volume":"202","author":"Xing W.","unstructured":"Xing, W., et al., Itm2a expression marks periosteal skeletal stem cells that contribute to bone fracture healing. J Clin Invest, 2024. 134(17).","journal-title":"J Clin Invest"},{"key":"e_1_3_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0303035"},{"key":"e_1_3_3_1_39_2","first-page":"587","volume-title":"Exp Mol Med","author":"Lin Z.","year":"2023","unstructured":"Lin, Z., et al., Circulating MiRNA-21-enriched extracellular vesicles promote bone remodeling in traumatic brain injury patients. Exp Mol Med, 2023. 55(3): p. 587-596."},{"key":"e_1_3_3_1_40_2","volume-title":"lncRNA CASC11 regulates the progress of delayed fracture healing via sponging miR-150-3p. J Orthop Surg Res","author":"Wu X.","year":"2024","unstructured":"Wu, X., et al., lncRNA CASC11 regulates the progress of delayed fracture healing via sponging miR-150-3p. J Orthop Surg Res, 2024. 19(1): p. 757."},{"key":"e_1_3_3_1_41_2","volume-title":"Long non-coding TRPM2-AS regulates fracture healing by targeting miR-545-3p\/Bmp2. J Orthop Surg Res","author":"Kang R.","year":"2024","unstructured":"Kang, R., et al., Long non-coding TRPM2-AS regulates fracture healing by targeting miR-545-3p\/Bmp2. J Orthop Surg Res, 2024. 19(1): p. 466."},{"key":"e_1_3_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0313768"},{"key":"e_1_3_3_1_43_2","first-page":"113","volume-title":"Cell Mol Life Sci","author":"Katchkovsky S.","year":"2022","unstructured":"Katchkovsky, S., et al., Competitive blocking of LRP4-sclerostin binding interface strongly promotes bone anabolic functions. Cell Mol Life Sci, 2022. 79(2): p. 113."},{"key":"e_1_3_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04652-1"},{"key":"e_1_3_3_1_45_2","first-page":"1","volume":"202","author":"Erickson C.B.","unstructured":"Erickson, C.B., et al., A timeseries analysis of the fracture callus extracellular matrix proteome during bone fracture healing. J Life Sci (Westlake Village), 2021. 3(4): p. 1-30.","journal-title":"J Life Sci (Westlake Village)"},{"key":"e_1_3_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-1562-9"},{"key":"e_1_3_3_1_47_2","first-page":"e111","volume":"202","author":"Becker K.","unstructured":"Becker, K., et al., Proteomic Analyses of Plasma From Patients With Fracture-Related Infection Reveals Systemic Activation of the Complement and Coagulation Cascades. J Orthop Trauma, 2024. 38(3): p. e111-e119.","journal-title":"J Orthop Trauma"},{"key":"e_1_3_3_1_48_2","first-page":"214","volume":"202","author":"Groven R.V.M.","unstructured":"Groven, R.V.M., et al., Fracture haematoma proteomics. Bone Joint Res, 2024. 13(5): p. 214-225.","journal-title":"Fracture haematoma proteomics. Bone Joint Res"},{"key":"e_1_3_3_1_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122204"},{"key":"e_1_3_3_1_50_2","first-page":"1184","volume":"202","author":"Nauta S.","unstructured":"Nauta, S., et al., Mass Spectrometry Reveals Molecular Effects of Citrulline Supplementation during Bone Fracture Healing in a Rat Model. J Am Soc Mass Spectrom, 2024. 35(6): p. 1184-1196.","journal-title":"J Am Soc Mass Spectrom"},{"key":"e_1_3_3_1_51_2","volume-title":"Inhibition of CK2\/ING4 Pathway Facilitates Non-Small Cell Lung Cancer Immunotherapy. Adv Sci (Weinh)","author":"Gou Q.","year":"2023","unstructured":"Gou, Q., et al., Inhibition of CK2\/ING4 Pathway Facilitates Non-Small Cell Lung Cancer Immunotherapy. Adv Sci (Weinh), 2023. 10(34): p. e2304068."},{"key":"e_1_3_3_1_52_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11070434"},{"key":"e_1_3_3_1_53_2","volume-title":"Biomolecules","author":"Jiang R.","year":"2024","unstructured":"Jiang, R., et al., Targeting Lactate: An Emerging Strategy for Macrophage Regulation in Chronic Inflammation and Cancer. Biomolecules, 2024. 14(10)."},{"key":"e_1_3_3_1_54_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1404441"},{"key":"e_1_3_3_1_55_2","first-page":"84","volume-title":"Mol Cell Endocrinol","author":"Wu Y.","year":"2017","unstructured":"Wu, Y., et al., Lactate induces osteoblast differentiation by stabilization of HIF1alpha. Mol Cell Endocrinol, 2017. 452: p. 84-92."},{"key":"e_1_3_3_1_56_2","volume-title":"Endothelial Cell-Derived Lactate Triggers Bone Mesenchymal Stem Cell Histone Lactylation to Attenuate Osteoporosis. Adv Sci (Weinh)","author":"Wu J.","year":"2023","unstructured":"Wu, J., et al., Endothelial Cell-Derived Lactate Triggers Bone Mesenchymal Stem Cell Histone Lactylation to Attenuate Osteoporosis. Adv Sci (Weinh), 2023. 10(31): p. e2301300."},{"key":"e_1_3_3_1_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-022-06063-5"},{"key":"e_1_3_3_1_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82912-y"},{"key":"e_1_3_3_1_59_2","first-page":"248","volume":"202","author":"Kalbas Y.","unstructured":"Kalbas, Y., et al., Systemic acylcarnitine levels are affected in response to multiple injuries and hemorrhagic shock: An analysis of lipidomic changes in a standardized porcine model. J Trauma Acute Care Surg, 2024. 97(2): p. 248-257.","journal-title":"J Trauma Acute Care Surg"},{"key":"e_1_3_3_1_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.5733"},{"key":"e_1_3_3_1_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-69594-y"},{"key":"e_1_3_3_1_62_2","first-page":"1929","volume":"202","author":"Lee J.W.","unstructured":"Lee, J.W., et al., Higher high-density lipoprotein cholesterol levels increased vertebral osteoporotic fracture, but reduced hip fracture in men based on the National Health Insurance Service-National Health Screening Cohort. Spine J, 2024. 24(10): p. 1929-1938.","journal-title":"Spine J"},{"key":"e_1_3_3_1_63_2","first-page":"117288","volume-title":"Bone","author":"Jaber M.","year":"2025","unstructured":"Jaber, M., et al., OMIBONE: Omics-driven computer model of bone regeneration for personalized treatment. Bone, 2025. 190: p. 117288."},{"key":"e_1_3_3_1_64_2","first-page":"1153","volume":"201","author":"Hussein A.I.","unstructured":"Hussein, A.I., et al., Serum proteomic assessment of the progression of fracture healing. J Orthop Res, 2018. 36(4): p. 1153-1163.","journal-title":"J Orthop Res"},{"key":"e_1_3_3_1_65_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1289127"},{"key":"e_1_3_3_1_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-80502-2"},{"key":"e_1_3_3_1_67_2","volume":"202","author":"Zhang Y.F.","unstructured":"Zhang, Y.F., et al., Deep learning algorithm-based multimodal MRI radiomics and pathomics data improve prediction of bone metastases in primary prostate cancer. J Cancer Res Clin Oncol, 2024. 150(2): p. 78.","journal-title":"J Cancer Res Clin Oncol"},{"key":"e_1_3_3_1_68_2","volume-title":"Identification of Up-Regulated ANXA3 Resulting in Fracture Non-Union in Patients With T2DM. Front Endocrinol (Lausanne)","author":"Liu C.","year":"2022","unstructured":"Liu, C., et al., Identification of Up-Regulated ANXA3 Resulting in Fracture Non-Union in Patients With T2DM. Front Endocrinol (Lausanne), 2022. 13: p. 890941."},{"key":"e_1_3_3_1_69_2","first-page":"3788","volume":"202","author":"Takahashi S.","unstructured":"Takahashi, S., et al., Machine-learning-based approach for nonunion prediction following osteoporotic vertebral fractures. Eur Spine J, 2023. 32(11): p. 3788-3796.","journal-title":"Eur Spine J"},{"key":"e_1_3_3_1_70_2","first-page":"1224","volume":"201","author":"Porter S.M.","unstructured":"Porter, S.M., et al., Automated measurement of fracture callus in radiographs using portable software. J Orthop Res, 2016. 34(7): p. 1224-33.","journal-title":"J Orthop Res"},{"key":"e_1_3_3_1_71_2","first-page":"945","volume":"201","author":"Cooke M.E.","unstructured":"Cooke, M.E., et al., Correlation between RUST assessments of fracture healing to structural and biomechanical properties. J Orthop Res, 2018. 36(3): p. 945-953.","journal-title":"J Orthop Res"},{"key":"e_1_3_3_1_72_2","volume":"202","author":"Xiao D.","unstructured":"Xiao, D., et al., DNA methylation-mediated Rbpjk suppression protects against fracture nonunion caused by systemic inflammation. J Clin Invest, 2023. 134(3).","journal-title":"J Clin Invest"},{"key":"e_1_3_3_1_73_2","volume":"202","author":"Burska A.N.","unstructured":"Burska, A.N., et al., Dynamics of Early Signalling Events during Fracture Healing and Potential Serum Biomarkers of Fracture Non-Union in Humans. J Clin Med, 2020. 9(2).","journal-title":"J Clin Med"},{"key":"e_1_3_3_1_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-021-00150-4"},{"key":"e_1_3_3_1_75_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40902-025-00465-w"},{"key":"e_1_3_3_1_76_2","first-page":"154","volume":"200","author":"Polat O.","unstructured":"Polat, O., S.S. Kilicoglu, and E. Erdemli, A controlled trial of glutamine effects on bone healing. Adv Ther, 2007. 24(1): p. 154-60.","journal-title":"Adv Ther"}],"event":{"name":"ISAIMS 2025: 2025 6th International Symposium on Artificial Intelligence for Medical Sciences","location":"Wuhan China","acronym":"ISAIMS 2025"},"container-title":["Proceedings of the 2025 6th International Symposium on Artificial Intelligence for Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/dl.acm.org\/doi\/pdf\/10.1145\/3777577.3777696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T18:10:39Z","timestamp":1768414239000},"score":1,"resource":{"primary":{"URL":"https:\/\/dl.acm.org\/doi\/10.1145\/3777577.3777696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,24]]},"references-count":76,"alternative-id":["10.1145\/3777577.3777696","10.1145\/3777577"],"URL":"https:\/\/doi.org\/10.1145\/3777577.3777696","relation":{},"subject":[],"published":{"date-parts":[[2025,10,24]]},"assertion":[{"value":"2026-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}