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This research was stimulated by rapidly growing amounts of industrial, transactional, sensor and other business data that arrives in real time and needs to be mined in real time. Under such circumstances, constant manual adjustment of models is in-efficient and with increasing amounts of data is becoming infeasible. Nevertheless, adaptive learning models are still rarely employed in business applications in practice. In the light of rapidly growing structurally rich 'big data', new generation of parallel computing solutions and cloud computing services as well as recent advances in portable computing devices, this article aims to identify the current key research directions to be taken to bring the adaptive learning closer to application needs. We identify six forthcoming challenges in designing and building adaptive learning (pre-diction) systems: making adaptive systems scalable, dealing with realistic data, improving usability and trust, integrat-ing expert knowledge, taking into account various application needs, and moving from adaptive algorithms towards adaptive tools. 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