{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:20:43Z","timestamp":1793298043294,"version":"4.5.0"},"reference-count":196,"publisher":"Annual Reviews","issue":"1","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,23]]},"abstract":"<jats:p>\n                    Despite the ubiquity of fungi in nature, only a small fraction are pathogenic to humans, and the majority of these fungi are opportunistic and affect immunocompromised individuals. In general, pathogen emergence is restricted by the ability of fungi to sense and withstand human host environmental cues and stresses. These stress responses in fungi involve immediate survival reactions as well as long-term adaptations. Additionally, some opportunistic pathogenic behavior suggests that virulence traits evolved for environmental survival, a concept known as exaptation. This review covers recent advances in examining fungal responses to host environments and focuses on stress pathways including HOG (high osmolarity glycerol) and CWI (cell wall integrity), thermotolerance mechanisms, CO\n                    <jats:sub>2<\/jats:sub>\n                    and oxygen sensing, nutrient and metal stresses, pH adaptation, and antimicrobial defenses. By focusing on both conserved and specialized responses, we highlight the critical role of stress adaptation in pathogenicity and potential avenues for further research and therapeutic intervention.\n                  <\/jats:p>","DOI":"10.1146\/annurev-micro-051024-033116","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T21:40:55Z","timestamp":1761255655000},"page":"449-473","source":"Crossref","is-referenced-by-count":18,"title":["Pathogenic Fungal Sensing and Responses to Stressful Host Environments"],"prefix":"10.1146","volume":"79","author":[{"given":"Jackson R.","family":"Rapala","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA; email:\u00a0tromeara@umich.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faith Anderson","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA; email:\u00a0tromeara@umich.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Larkin","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA; email:\u00a0tromeara@umich.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa R.","family":"O'Meara","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA; email:\u00a0tromeara@umich.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22","reference":[{"issue":"12","key":"B1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s12275-023-00096-8","article-title":"Transcription factors Tec1 and Tec2 play key roles in the hyphal growth and virulence of Mucor lusitanicus through increased mitochondrial oxidative metabolism","volume":"61","year":"2023","journal-title":"J. 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Immunol."},{"key":"B113","doi-asserted-by":"crossref","first-page":"10740","DOI":"10.1038\/ncomms10740","article-title":"Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts","volume":"7","year":"2016","journal-title":"Nat. Commun."},{"issue":"1","key":"B114","doi-asserted-by":"crossref","first-page":"e1004076","DOI":"10.1371\/journal.pgen.1004076","article-title":"Zinc finger transcription factors displaced SREBP proteins as the major sterol regulators during Saccharomycotina evolution","volume":"10","year":"2014","journal-title":"PLOS Genet"},{"key":"B115","doi-asserted-by":"crossref","first-page":"918","DOI":"10.3389\/fmicb.2019.00918","article-title":"Aspergillus fumigatus high osmolarity glycerol mitogen activated protein kinases SakA and MpkC physically interact during osmotic and cell wall stresses","volume":"10","year":"2019","journal-title":"Front. 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Biochem. Biotechnol."},{"issue":"8","key":"B122","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1099\/mic.0.28038-0","article-title":"The MAP kinase Mkc1p is activated under different stress conditions in Candida albicans","volume":"151","year":"2005","journal-title":"Microbiology"},{"issue":"5773","key":"B123","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1126\/science.1124105","article-title":"Global control of dimorphism and virulence in fungi","volume":"312","year":"2006","journal-title":"Science"},{"issue":"12","key":"B124","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1073\/pnas.0710448105","article-title":"Temperature-induced switch to the pathogenic yeast form of Histoplasma capsulatum requires Ryp1, a conserved transcriptional regulator","volume":"105","year":"2008","journal-title":"PNAS"},{"issue":"8","key":"B125","first-page":"fnw292","article-title":"Role of the Talaromyces marneffei (Penicillium marneffei) sakA gene in nitrosative stress response, conidiation and red pigment production","volume":"364","year":"2017","journal-title":"FEMS Microbiol. Lett."},{"issue":"2","key":"B126","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/myc.13225","article-title":"Increased incidence of candidemia in a tertiary care hospital with the COVID-19 pandemic","volume":"64","year":"2021","journal-title":"Mycoses"},{"issue":"5","key":"B127","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2323\/jgam.2021.02.001","article-title":"Vph1 is associated with the copper homeostasis of Cryptococcus neoformans serotype D","volume":"67","year":"2021","journal-title":"J. Gen. Appl. Microbiol."},{"issue":"7","key":"B128","doi-asserted-by":"crossref","first-page":"e3000358","DOI":"10.1371\/journal.pbio.3000358","article-title":"Global proteomic analyses define an environmentally contingent Hsp90 interactome and reveal chaperone-dependent regulation of stress granule proteins and the R2TP complex in a fungal pathogen","volume":"17","year":"2019","journal-title":"PLOS Biol"},{"issue":"10","key":"B129","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.tim.2017.05.003","article-title":"The Hsp90 chaperone network modulates Candida virulence traits","volume":"25","year":"2017","journal-title":"Trends Microbiol"},{"issue":"6","key":"B130","doi-asserted-by":"crossref","first-page":"e1006142","DOI":"10.1371\/journal.pgen.1006142","article-title":"Mapping the Hsp90 genetic network reveals ergosterol biosynthesis and phosphatidylinositol-4-kinase signaling as core circuitry governing cellular stress","volume":"12","year":"2016","journal-title":"PLOS Genet"},{"issue":"4","key":"B131","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1128\/MCB.01359-13","article-title":"The Cryptococcus neoformans Rim101 transcription factor directly regulates genes required for adaptation to the host","volume":"34","year":"2014","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"B132","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1128\/mr.55.2.234-258.1991","article-title":"Mucor dimorphism","volume":"55","year":"1991","journal-title":"Microbiol. Rev."},{"issue":"4","key":"B133","doi-asserted-by":"crossref","first-page":"e1005159","DOI":"10.1371\/journal.pgen.1005159","article-title":"The Cryptococcus neoformans alkaline response pathway: identification of a novel rim pathway activator","volume":"11","year":"2015","journal-title":"PLOS Genet"},{"issue":"9","key":"B134","doi-asserted-by":"crossref","first-page":"e1005873","DOI":"10.1371\/journal.ppat.1005873","article-title":"Calcineurin targets involved in stress survival and fungal virulence","volume":"12","year":"2016","journal-title":"PLOS Pathog"},{"key":"B135","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.3389\/fmicb.2020.01834","article-title":"Metabolic adaptation of Paracoccidioides brasiliensis in response to in vitro copper deprivation","volume":"11","year":"2020","journal-title":"Front. 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Chem."},{"issue":"10","key":"B138","first-page":"e02060","article-title":"Malassezia responds to environmental pH signals through the conserved Rim\/Pal pathway","volume":"15","year":"2024","journal-title":"mBio"},{"issue":"6657","key":"B139","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1126\/science.abq3178","article-title":"Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism","volume":"381","year":"2023","journal-title":"Science"},{"issue":"1","key":"B140","first-page":"e02211","article-title":"Lipid signaling via Pkh1\/2 regulates fungal CO2 sensing through the kinase Sch9","volume":"8","year":"2017","journal-title":"mBio"},{"issue":"6","key":"B141","doi-asserted-by":"crossref","first-page":"e1010195","DOI":"10.1371\/journal.ppat.1010195","article-title":"Interactions between copper homeostasis and the fungal cell wall affect copper stress resistance","volume":"18","year":"2022","journal-title":"PLOS Pathog"},{"issue":"4","key":"B142","doi-asserted-by":"crossref","first-page":"e1010946","DOI":"10.1371\/journal.ppat.1010946","article-title":"A fungal lytic polysaccharide monooxygenase is required for cell wall integrity, thermotolerance, and virulence of the fungal human pathogen Cryptococcus neoformans","volume":"19","year":"2023","journal-title":"PLOS Pathog"},{"key":"B143","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev-micro-032521-021745","article-title":"Recent advances in understanding the human fungal pathogen hypoxia response in disease progression","volume":"77","year":"2023","journal-title":"Annu. Rev. Microbiol."},{"key":"B144","doi-asserted-by":"crossref","first-page":"907519","DOI":"10.3389\/fcimb.2022.907519","article-title":"Distinct cohorts of Aspergillus fumigatus transcription factors are required for epithelial damage occurring via contact- or soluble effector-mediated mechanisms","volume":"12","year":"2022","journal-title":"Front. Cell. Infect. 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Biol."},{"issue":"6272","key":"B158","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1126\/science.aad5589","article-title":"Airway acidification initiates host defense abnormalities in cystic fibrosis mice","volume":"351","year":"2016","journal-title":"Science"},{"issue":"2","key":"B159","first-page":"e02712","article-title":"Metabolism of gluconeogenic substrates by an intracellular fungal pathogen circumvents nutritional limitations within macrophages","volume":"11","year":"2020","journal-title":"mBio"},{"key":"B160","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1146\/annurev-micro-030117-020444","article-title":"Copper acquisition and utilization in fungi","volume":"71","year":"2017","journal-title":"Annu. Rev. 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Prod."},{"key":"B170","doi-asserted-by":"crossref","first-page":"e58349","DOI":"10.7554\/eLife.58349","article-title":"Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs","volume":"9","year":"2020","journal-title":"eLife"},{"issue":"10","key":"B171","doi-asserted-by":"crossref","first-page":"myad101","DOI":"10.1093\/mmy\/myad101","article-title":"Cryptococcus neoformans requires the TVF1 gene for thermotolerance and virulence","volume":"61","year":"2023","journal-title":"Med. 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