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One, occurring most often in childhood, is a rare but deadly thrombomicroangiopathy called atypical hemolytic uremic syndrome. The other, age-related macular degeneration, is the most common form of blindness in the elderly. Their seemingly unrelated clinical presentations and pathologies share the common theme of overactivity of the complement system's alternative pathway. This review summarizes insights gained from contemporary genetics for understanding how dysregulation of this powerful innate immune system leads to these human diseases. <\/jats:p>","DOI":"10.1146\/annurev-pathol-012615-044145","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T19:11:43Z","timestamp":1481656303000},"page":"25-52","source":"Crossref","is-referenced-by-count":89,"title":["Complement Dysregulation and Disease: Insights from Contemporary Genetics"],"prefix":"10.1146","volume":"12","author":[{"given":"M. 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