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Furthermore, its aberrant activation is also a hallmark of various hepatic pathologies. In addition to its signaling function, \u03b2-catenin also plays a role at adherens junctions. Wnt\/\u03b2-catenin signaling also influences the function of many different cell types. Due to this myriad of functions, Wnt\/\u03b2-catenin signaling is complex, context-dependent, and highly regulated. In this review, we discuss the Wnt\/\u03b2-catenin signaling pathway, its role in cell-cell adhesion and liver function, and the cell type\u2013specific roles of Wnt\/\u03b2-catenin signaling as it relates to liver physiology and pathobiology.<\/jats:p>","DOI":"10.1146\/annurev-pathol-020117-044010","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T13:38:33Z","timestamp":1510321113000},"page":"351-378","source":"Crossref","is-referenced-by-count":453,"title":["Wnt\/\u03b2-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology"],"prefix":"10.1146","volume":"13","author":[{"given":"Jacquelyn O.","family":"Russell","sequence":"first","affiliation":[{"name":"Division of Experimental Pathology, Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satdarshan 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